Blaise ketone synthesis

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The Blaise ketone synthesis (named after Edmond E. Blaise) is the chemical reaction of acid chlorides with organozinc compounds to give ketones.[1] [2]

The Blaise ketone synthesis

The reaction also works with organocuprates.[3][4]

Reviews have been written.[5] [6]


Blaise-Maire reaction[edit]

The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.[7]

See also[edit]


  1. ^ Blaise, E. E.; Koehler, A. (1910). "Synthèse au moyen des dérivés organo-métalliques mixtes du zinc (II).". Bull. Soc. Chim. Paris. 7: 215 –227. 
  2. ^ Blaise, E. E. (1911). Bull. Soc. Chim. 9: 1.  Missing or empty |title= (help)
  3. ^ Posner, G. H.; Whitten, C. E. (1976). "Secondary and Tertiary Alkyl Ketones from Carboxylic Acid Chlorides and Lithium Phenylthio(Alkyl)Cuprate Reagents: tert-Butyl Phenyl Ketone". Org. Synth. 55: 122. ; Coll. Vol., 6, p. 248 
  4. ^ Fujisawa, T.; Sato, T. (1988). "Ketones from Carboxylic Acids and Grignard Reagents: Methyl 6-Oxodecanoate". Org. Synth. 66: 116. ; Coll. Vol., 8, p. 441 
  5. ^ Cason, J. (1947). "The Use of Organocadmium Reagents for the Preparation of Ketones". Chem. Rev. 40 (1): 17. PMID 20287882. doi:10.1021/cr60125a002. 
  6. ^ Shirley, D. A. (1954). "The Synthesis of Ketones from Acid Halides and Organometallic Compounds of Magnesium, Zinc, and Cadmium". Org. React. 8: 29. ISBN 0471264180. doi:10.1002/0471264180.or008.02. 
  7. ^ Blaise, E. E.; Maire, M. (1907). Compt. Rend. 145: 73.  Missing or empty |title= (help)