Blanco is a rural unincorporated community located on State Highway 63 in Pittsburg County, Oklahoma, United States. The ZIP code is 74528.
The community was named for Ramón Blanco y Erenas, one-time governor general of Cuba. The post office opened August 31, 1901.
- Pryor McBee, Major League Baseball pitcher, was born in Blanco in 1901.
- Royce H. Savage, United States Federal Court judge, was born in Blanco in 1904.
- Gene Stipe, the longest-serving member of the Oklahoma Senate was born in Blanco in 1926.
- Shirk, George H. Oklahoma Place Names. Norman: University of Oklahoma Press, 1987. ISBN 0-8061-2028-2.