Bleomycin hydrolase

BLMH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CB5, 2CB5
Identifiers
Aliases	BLMH, BH, BMH, bleomycin hydrolase
External IDs	OMIM: 602403; MGI: 1345186; HomoloGene: 330; GeneCards: BLMH; OMA:BLMH - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,292,056 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,878,205 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of leg; ; skin of abdomen; ; skin of thigh; ; epithelium of colon; ; body of pancreas; ; Descending thoracic aorta; ; mucosa of esophagus; ; stromal cell of endometrium; ; body of uterus;
	Top expressed in
	fossa; ; condyle; ; primitive streak; ; hair follicle; ; renal corpuscle; ; internal carotid artery; ; esophagus; ; vas deferens; ; external carotid artery; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity; carboxypeptidase activity; cysteine-type endopeptidase activity; protein binding; cysteine-type peptidase activity; aminopeptidase activity; identical protein binding;
Cellular component	extracellular exosome; cytosol; nucleus; cytoplasm;
Biological process	protein polyubiquitination; proteolysis; response to toxic substance; homocysteine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	642
	104184
	ENSG00000108578
	ENSMUSG00000020840
	Q13867
	Q8R016
	NM_000386
	NM_178645
	NP_000377
	NP_848760
	Wikidata
View/Edit Human	View/Edit Mouse

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

BLMH has been shown to interact with RPL29,^[8] RPL11,^[8] UBE2I^[9] and Amyloid precursor protein.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108578 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020840 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ferrando AA, Pendas AM, Llano E, Velasco G, Lidereau R, Lopez-Otin C (January 1998). "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J Biol Chem. 272 (52): 33298–304. doi:10.1074/jbc.272.52.33298. PMID 9407121.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Montoya SE, Ferrell RE, Lazo JS (October 1997). "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res. 57 (19): 4191–5. PMID 9331073.
^ "Entrez Gene: BLMH bleomycin hydrolase".
^ ^a ^b Koldamova, R P; Lefterov I M; DiSabella M T; Almonte C; Watkins S C; Lazo J S (June 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry. 38 (22). UNITED STATES: 7111–7. doi:10.1021/bi990135l. ISSN 0006-2960. PMID 10353821. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Koldamova, R P; Lefterov I M; DiSabella M T; Lazo J S (December 1998). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. 54 (6). UNITED STATES: 954–61. ISSN 0026-895X. PMID 9855622. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ Lefterov, I M; Koldamova R P; Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. 14 (12). UNITED STATES: 1837–47. doi:10.1096/fj.99-0938com. ISSN 0892-6638. PMID 10973933. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading