Blood in My Eye garnered mixed reviews from music critics, skeptical of Ja's lyrical skills as a hardcore rapper. At Metacritic, which assigns a normalized rating out of 100 to reviews from mainstream critics, the album received an average score of 45, based on 8 reviews.
Beccy Lindon of The Guardian called the record "a rough, back-to-basics rap album", noting that it is filled with guest verses from hardcore rappers and devoid of R&B artists, concluding that it is "more concerned with answering critics and continuing the backbiting with the Death Row camp." Jon Caramanica, writing for Rolling Stone, commended Ja for breaking away from his usual love duet formula to deliver shots at other rappers but said that "the boasts here feel utterly tired. And so does the attitude." Michael Endelman of Entertainment Weekly found the album to be "a dull slog with a dearth of hooks and a surfeit of gangsta clichés."
Steve 'Flash' Juon of RapReviews criticized the narrow-minded lyrical takedowns and suggested that Ja sticks to mainstream R&B/hip-hop duets, despite crediting the production and collaborations with Hussein Fatal, saying that, "All things considered though, this short 45 minute album will not solve Ja's problems, nor will it restore him to chart dominance."AllMusic editor Jason Birchmeier called it "a very focused and heartfelt album", much more than his debut Venni Vetti Vecci, but felt that Ja worked better as a mainstream rapper crafting "catchy pop-rap tracks with grimy posturing and singalong hooks." He added that listeners would not get much out of the record, saying "there are only two quality songs, a lot of redundant trash-talking, and an overall sense of ridiculousness that pervades."