In Elle magazine, the song was named one of 10 "essential" songs produced by Jack White.NME listed the single as one of 20 "unspeakably exciting" songs by White. NME and Rolling Stone pointed out the song's emphatic guitar work based on "Jack Lawrence's grunting fuzz bass [and] Dean Fertita's abrasive skidding guitar".Spin said the guitar runs were "Sabbath-worthy", referring to the hard rock of Black Sabbath. White's vocals were seen to bury those of singer Alison Mosshart.Antiquiet observed that the song was unusual for the Dead Weather in that it felt like a solo piece featuring White.
The video for "Blue Blood Blues" premiered on teamcoco.com, the official website of Jack White's friend Conan O'Brien, on June 24, 2010. The recording is an edited live performance from May 3, 2010, at Third Man Records. The style of the video is high contrast solarizedblack & white, similar to the video for "Fried My Little Brains" by the Kills, the other band of Dead Weather singer Alison Mosshart.
In September 2010, Jack White announced a new format of vinyl record: a "triple-decker record" which is an A-side 12" record with a 7" record sandwiched inside containing a hidden track. To listen to the 7" record, the listener must crack the 12" record open with a knife into two circular plates, revealing the inner record which can then be played separately. "Blue Blood Blues" was the first song appearing in this format, in a limited release of 300 units that contained the song "I Feel Strange" inside. A record-pressing plant in Nashville, Tennessee, filled the custom order.