Blue Brain Project
This article needs to be updated.October 2016)(
The Blue Brain Project is a Swiss brain research initiative that aims to create a digital reconstruction of the mouse brain. The project was founded in May 2005 by the Brain and Mind Institute of École Polytechnique Fédérale de Lausanne (EPFL) in Switzerland. Its mission is to use biologically-detailed digital reconstructions and simulations of the mammalian brain to identify the fundamental principles of brain structure and function.
The project is headed by the founding director Henry Markram—who also launched the European Human Brain Project—and is co-directed by Felix Schürmann, Adriana Salvatore and Sean Hill. Using a Blue Gene supercomputer running Michael Hines's NEURON software, the simulation involves a biologically realistic model of neurons and an empirically reconstructed model connectome.
There are a number of collaborations, including the Cajal Blue Brain, which is coordinated by the Supercomputing and Visualization Center of Madrid (CeSViMa), and others run by universities and independent laboratories.
The initial goal of the project, which was completed in December 2006, was the creation of a simulated rat neocortical column, which is considered by some researchers to be the smallest functional unit of the neocortex, which is thought to be responsible for higher functions such as conscious thought. In humans, each column is about 2 mm (0.079 in) in length, has a diameter of 0.5 mm (0.020 in) and contains about 60,000 neurons. Rat neocortical columns are very similar in structure but contain only 10,000 neurons and 108 synapses. Between 1995 and 2005, Markram mapped the types of neurons and their connections in such a column.
By 2005, the first cellular model was completed. The first artificial cellular neocortical column of 10,000 cells was built by 2008. By July 2011, a cellular mesocircuit of 100 neocortical columns with a million cells in total was built. A cellular rat brain had been planned[needs update] for 2014 with 100 mesocircuits totalling a hundred million cells. A cellular human brain equivalent to 1,000 rat brains with a total of a hundred billion cells has been predicted to be possible by 2023.
In November 2007, the project reported the end of the first phase, delivering a data-driven process for creating, validating, and researching the neocortical column.
In 2015, scientists at École Polytechnique Fédérale de Lausanne (EPFL) developed a quantitative model of the previously unknown relationship between the glial cell astrocytes and neurons. This model describes the energy management of the brain through the function of the neuro-glial vascular unit (NGV). The additional layer of neuron-glial cells is being added to Blue Brain Project models to improve functionality of the system.
In 2017, Blue Brain Project discovered that neural cliques connected to one another in up to eleven dimensions. The project's director suggested that the difficulty of understanding the brain is partly because the mathematics usually applied for studying networks cannot detect that many dimensions. The Blue Brain Project was able to model these networks using algebraic topology.
In 2018, Blue Brain Project released its first digital 3D brain cell atlas which, according to ScienceDaily, is like "going from hand-drawn maps to Google Earth", providing information about major cell types, numbers, and positions in 737 regions of the brain.
In 2019, Idan Segev, one of the computational neuroscientists working on the Blue Brain Project, gave a talk titled: "Brain in the computer: what did I learn from simulating the brain." In his talk, he mentioned that the whole cortex for the mouse brain was complete and virtual EEG experiments would begin soon. He also mentioned that the model had become too heavy on the supercomputers they were using at the time, and that they were consequently exploring methods in which every neuron could be represented as a neural network (see citation for details).
The Blue Brain Project has developed a number of software to reconstruct and to simulate the mouse brain.
BluePyOpt is a tool that is used to build electrical models of single neurons. For this, it uses evolutionary algorithms to constrain the parameters to experimental electrophysiological data. Attempts to reconstruct single neurons using BluePyOpt are reported by Rosanna Migliore, and Stefano Masori. It is an open source software and available for everyone on GitHub.
CoreNEURON is a supplemental tool to NEURON, which allows large scale simulation by boosting memory usage and computational speed. It is an open source software and available for everyone on GitHub.
SONATA is a joint effort between Blue Brain Project and Allen Institute for Brain Science, to develop a standard for data format, which realises a multiple platform working environment with greater computational memory and efficiency. It is an open source software and available for everyone on GitHub.
The project is funded primarily by the Swiss government and the Future and Emerging Technologies (FET) Flagship grant from the European Commission, and secondarily by grants and donations from private individuals. The EPFL bought the Blue Gene computer at a reduced cost because it was still a prototype and IBM was interested in exploring how applications would perform on the machine. BBP was viewed as a validation of the Blue Gene supercomputer concept.
Cajal Blue Brain
The Cajal Blue Brain Project is coordinated by the Technical University of Madrid and uses the facilities of the Supercomputing and Visualization Center of Madrid and its supercomputer Magerit. The Cajal Institute also participates in this collaboration. The main lines of research currently being pursued at Cajal Blue Brain include neurological experimentation and computer simulations. Nanotechnology, in the form of a newly designed brain microscope, plays an important role in its research plans.
A 10-part documentary is being made by Noah Hutton; each installment will explore the year-long workings of the project at the EPFL. Filming began in 2009, and the documentary is planned to be released in 2020. Other similar research projects are also mentioned.
- Artificial brain
- Artificial intelligence
- Artificial neural network
- BRAIN Initiative
- Cognitive architecture
- Cognitive science
- Computational neuroscience
- Google Brain
- Human Brain Project
- Neural network
- Outline of brain mapping
- Outline of the human brain
- Project Joshua Blue
- Simulation argument
- Simulated reality
- Social simulation
- Whole brain emulation
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|Wikimedia Commons has media related to Blue Brain Project.|
- Markram H (February 2006). "The blue brain project". Nature Reviews. Neuroscience. 7 (2): 153–60. doi:10.1038/nrn1848. PMID 16429124. S2CID 15752137.
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- NEURON documentation.
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- Out of the Blue -- Can a thinking, remembering, decision-making, biologically accurate brain be built from a supercomputer?, Seed Magazine, March 2008
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- Firing Up the Blue Brain -"We Are 10 Years Away From a Functional Artificial Human Brain" Luke McKinney, July 2009
- Henry Ankara builds a brain in a supercomputer TED Conference. July 2009
- Indian startup to help copy your brain on computers Silicon India. 1 February 2010