Blueberry muffin baby

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Blueberry muffin baby
Neuroblastoma Muffin.jpg
"Blueberry muffin" appearance of blue-grey nodules under the skin, here due to neuroblastoma

Blueberry muffin baby is the characteristic distributed purpura occurring as a result of extramedullary hematopoiesis found in infants.[1][2]:826 The purpura are often generalized, but occur more often on the trunk, head, and neck.[3] The name is from the superficial similarity to a blueberry muffin.


The condition was originally considered characteristic of rubella, but is now considered to be potentially associated with many other conditions,[4] such as cytomegalovirus[5], metastatic neuroblastoma, and Congenital Leukemia.


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  1. ^ Shaffer MP, Walling HW, Stone MS (August 2005). "Langerhans cell histiocytosis presenting as blueberry muffin baby". J. Am. Acad. Dermatol. 53 (2 Suppl 1): S143–6. doi:10.1016/j.jaad.2005.01.015. PMID 16021165.
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. ^ Blueberry muffin baby: A pictoral differential diagnosis Archived July 11, 2012, at the Wayback Machine Vandana Mehta, C Balachandran, Vrushali Lonikar. Dermatology Online Journal 14 (2): 8 .
  4. ^ Mehta V, Balachandran C, Lonikar V (2008). "Blueberry muffin baby: a pictoral differential diagnosis". Dermatol. Online J. 14 (2): 8. PMID 18700111.
  5. ^ Gaffin JM, Gallagher PG (November 2007). "Picture of the month. Blueberry muffin baby (extramedullary hematopoiesis) due to congenital cytomegalovirus infection". Arch Pediatr Adolesc Med. 161 (11): 1102–3. doi:10.1001/archpedi.161.11.1102. PMID 17984414.

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