Bodroux–Chichibabin aldehyde synthesis

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The Bodroux–Chichibabin aldehyde synthesis is a chemical reaction whereby a Grignard reagent is converted to an aldehyde one carbon longer.

Bodroux-Chichibabin aldehyde synthesis

Reaction of a Grignard reagent with triethyl orthoformate gives an acetal, which can be hydrolyzed to an aldehyde. For example, the synthesis of n-hexanal:[1]

Bodroux-Chichibabin hexanal.[1]

See also[edit]


  1. ^ a b G. Bryant Bachman (1943). "n-Hexaldehyde". Org. Synth. ; Coll. Vol., 2, p. 323