Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10gene.
BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins. It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.
Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun.11 (3): 232–8. doi:10.1038/gene.2010.1. PMID20237496.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature434 (7034): 724–31. doi:10.1038/nature03466. PMID15815621.
Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem.280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID16049014.
Nakano N, Hori H, Abe M, et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol.293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID17921333.
David L, Mallet C, Mazerbourg S, et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID17068149.