Bone morphogenetic protein 5

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Bone morphogenetic protein 5
Identifiers
Symbols BMP5 ; MGC34244
External IDs OMIM112265 MGI88181 HomoloGene22412 GeneCards: BMP5 Gene
RNA expression pattern
PBB GE BMP5 205431 s at tn.png
PBB GE BMP5 205430 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 653 12160
Ensembl ENSG00000112175 ENSMUSG00000032179
UniProt P22003 P49003
RefSeq (mRNA) NM_021073 NM_007555
RefSeq (protein) NP_066551 NP_031581
Location (UCSC) Chr 6:
55.75 – 55.88 Mb
Chr 9:
75.78 – 75.9 Mb
PubMed search [1] [2]

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[1][2][3]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[3]

References[edit]

  1. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904. 
  2. ^ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864. 
  3. ^ a b "Entrez Gene: BMP5 bone morphogenetic protein 5". 

Further reading[edit]

  • Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America 87 (24): 9843–7. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636. 
  • Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036. 
  • You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science 40 (2): 296–311. PMID 9950587. 
  • Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221. 
  • Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology 16 (4): 1013–9. PMID 11642720. 
  • Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867. 
  • Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science 115 (Pt 4): 753–60. PMID 11865031. 
  • Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (May 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. 
  • Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision 8: 241–50. PMID 12131877. 
  • Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436. 
  • Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325. 
  • Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal 46 (3): 389–96. PMID 15861517. 
  • Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506. 
  • Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). "Extreme context specificity in differential allelic expression". Human Molecular Genetics 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.