Bone morphogenetic protein 6

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Protein BMP6 PDB 2QCW.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases BMP6, VGR, VGR1, bone morphogenetic protein 6
External IDs OMIM: 112266 MGI: 88182 HomoloGene: 1300 GeneCards: 654
Genetically Related Diseases
Disease Name References
cleft lip and palate
RNA expression pattern
PBB GE BMP6 206176 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 7.73 – 7.88 Mb Chr 13: 38.35 – 38.5 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.[1][2][3]

The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 [4]:386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.



  1. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904. 
  2. ^ Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478. 
  3. ^ a b "Entrez Gene: BMP6 bone morphogenetic protein 6". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.