The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.
^Ozkaynak E, Schnegelsberg PN, Jin DF, Clifford GM, Warren FD, Drier EA, Oppermann H (Jan 1993). "Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis". J Biol Chem267 (35): 25220–7. PMID1460021.
^DiLeone RJ, King JA, Storm EE, Copeland NG, Jenkins NA, Kingsley DM (Jun 1997). "The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4". Genomics40 (1): 196–8. doi:10.1006/geno.1996.4533. PMID9070944.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.
Wen XZ, Akiyama Y, Baylin SB, Yuasa Y (2006). "Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas". Oncogene25 (18): 2666–73. doi:10.1038/sj.onc.1209297. PMID16314833.
Saito T, Ji G, Shinzawa H, et al. (2004). "Genetic variations in humans associated with differences in the course of hepatitis C". Biochem. Biophys. Res. Commun.317 (2): 335–41. doi:10.1016/j.bbrc.2004.03.056. PMID15063762.