Booster dose

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In medicine, a booster dose is an extra administration of a vaccine after an earlier (prime) dose. After initial immunization, a booster injection or booster dose is a re-exposure to the immunizing antigen cell. It is intended to increase immunity against that antigen back to protective levels after it has been shown to have decreased or after a specified period. For example, tetanus shot boosters are often recommended every 10 years.[1] If a patient receives a booster dose but already has a high level of antibody, then a reaction called an Arthus reaction could develop, a localized form of Type III hypersensitivity, induced by fixation[disambiguation needed] of complement by preformed circulating antibodies. In severe cases, the degree of complement fixation can be so substantial that it induces local tissue necrosis.[2]

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  1. ^ Tetanus: Prevention, Mayo Clinic, 2006-09-21, retrieved 2008-07-17 
  2. ^ University of the Sciences in Philadelphia, David B. Troy, Joseph Price Remington, Paul Beringer (2005). Remington: the science and practice of pharmacy. Lippincott Williams & Wilkins. ISBN 0-7817-4673-6.