In a 2007 interview, bandmate Josh Homme stated "Jesse Hughes and I have a theory; we’re socially liberal but government conservative guys". Hughes has also said "I wanted to be a Republican politician, for God sakes. I’m a conservative, dude".
Hughes and Homme formed Eagles of Death Metal in 1998. Hughes credits Homme with saving his life, claiming that during the recording of the second Eagles of Death Metal album Death By Sexy, he fell into serious drug addiction and that Homme not only drove him to rehabilitation, but paid for it as well.
In September 2011, Hughes released his first solo album under the nickname Boots Electric. The album, Honkey Kong, was released on Dangerbird Records. He played his first show in Columbus, Ohio, on August 12, 2011, at the CD 101 Summerfest Eve.
On December 6, 2012 Jesse Hughes became an ordained minister with the Universal One Church 
Hughes uses many different nicknames, including "J. Devil" (or simply "The Devil") as well as "Boots Electric" ("Boots" for short) and "Fabulous Weapon" (both of which were band names used by Hughes' father). In an interview Hughes revealed that his band mate Josh Homme gave him "The Devil" nickname when he was thirteen. "I used to get picked on a lot by Karl Doyle" says Hughes, "And when I would get picked on severely, or if it really made a point to me, I would get vengeance, but I would get vengeance in the way that I could, which was mostly clever and all consuming. Joshua once witnessed me in the moment I was about to enact vengeance upon someone, and he just said, 'You're the fucking devil dude,' and it stuck."