In March, Francisco Madero led 130 men at the Battle of Casas Grandes in Chihuahua. The rebels lost the battle, but later the federals retreated which left Madero's army in control. Madero then began smuggling arms and ammunition on a large scale from across the border.
On 16 March, rebel saboteurs in Ciudad Juárez bombed the barracks and homes of the Mexican Army garrison. A large nitroglycerin explosion was seen on the American side of the border. Two days later, a large cannon which sat in the town square of El Paso, Texas, disappeared and was presumably taken to Ciudad Juárez.
Maderista rebels fought federal troops loyal to Porfirio Díaz at Agua Prieta, Sonora, in April. United States troops across the border in Douglas, Arizona, were attacked by Mexican forces and in response the Americans intervened which left the rebels in control of the town.
Madero's rebels under Pancho Villa and Pascual Orozco attacked federal forces at the major Second Battle of Ciudad Juarez from 7 April-10 May. The American garrison of El Paso, Texas, exchanged fire with rebels resulting in minor casualties on both sides.
Porfirio Díaz exiled. Francisco Madero becomes President of Mexico and calls for an end to warfare in the country. He offered to pay rebels of different factions but only if they would lay down their arms or join his new federal Army.
United States Army continues garrisoning American border towns.
General Pasqual Orozco rebels against President Madero and begins a campaign in the border state of Chihuahua. Madero responds by sending an army which defeated Orozco's troops in thee major battles. Villa rebels against the Madero government soon after.
Federal forces of President Francisco Madero establish Fort Tijuana along the international border with California in response to the Magonista campaign.
On 9 April, the Tampico Affair, an incident in Tampico, Tamaulipas, between United States Navy sailors and Mexican troops, occurred. It resulted in the severing of diplomatic relations between Mexico and the United States.
The longest battle of the Mexican Revolution was fought at Naco, Sonora, across the border from Fort Naco and Naco, Arizona. Pancho Villa's men attacked General Obregón's garrison on 17 October. During the 119 following days of siege warfare Villa was defeated. Also during the battle several United States Army Buffalo Soldiers stationed in Naco, Arizona, were wounded by rebels shooting into their camp. Eight men were wounded but they did not return fire and were later recognized for their good discipline.
Pancho Villa and Emiliano Zapata capture Mexico City but soon after are forced to retreat by Álvaro Obregón's army.
Carrancistas draft the Plan de San Diego, an operation to overthrow the state governments of Texas, New Mexico, Arizona, and California by starting a race war. The plan was discovered by the Americans after a Carrancista leader was arrested in Texas though some fighting did occur in the form of raids, launched by rebels into Texas territory.
Pancho Villa attacks General Obregón's Constitutionalist garrison at Nogales, Sonora. Villa initiates a siege but over time is defeated due to the lack of artillery and insufficient supplies. During the siege the United States 12th Infantry garrison of Nogales, Arizona was attacked by Villistas and in turn skirmished for a half hour. Only one American was killed along with several of Villa's rebels.
Villistas and Constitutionalists fought again at Agua Prieta in November. Later, Villa attributed his defeat to large searchlights used during the battle by the United States Army garrison of Douglas, Arizona. The battle ended in defeat for Villa and led to the more disastrous Battle of Hermosillo on 15 November. At this time, Villa's forces pillaged the city instead of fighting the garrison, resulting in a repulse. Also at this time Constitutionalist forces were allowed access to American railways for troop movement.
Now losing the war, Pancho Villa decided to raid Columbus, New Mexico, for supplies on 9 March 1916. The raid did not go as planned and Villa's 500 cavalrymen were defeated by over 300 United States infantry and cavalry who were stationed in a border fort outside of town. Columbus was heavily damaged by the Villistas who burned several of the town's buildings. Sixty to eighty Villistas were killed along with over a dozen American troops and civilians.
In response to the attack on Columbus, President Wilson ordered General John J. Pershing to proceed into Mexico with over 5,000 men to capture or kill Pancho Villa, thus beginning the Pancho Villa Expedition.
On 5 May, Villa's rebels attacked two more American border towns, Glenn Springs, Texas, and Boquillas, Texas. Over 200 men under Rodriguez Ramirez and Natividad Álvarez crossed the Texas border with the intention of capturing supplies. At Glenn Springs, a United States Army squad of nine men resisted the Villista attack for several hours but eventually the raiders set fire to the adobe building the Americans were held up in and forced the 14th Infantry men to retreat. Three of the United States troops were killed and four others were wounded. One young American boy was also killed by the Mexicans. At Boquillas, 12 mi (19 km) from Glenn Springs, the Americans there captured Alvarez and discovered he was a Lieutenant Colonel in Pancho Villa's División del Norte and was a veteran of the Battle of Celaya.
The raiders of Glenn Springs and Boquillas took two captives with them when they withdrew across the border. Jesse Deemer and Monroe Payne who were later rescued by American Army forces during a small cavalry expedition into Mexico. The expedition of eighty men, two wagons and a car began on 8 May from Marathon, Texas, and was under the command of ColonelFrederick W. Sibley and Colonel George T. Langhorne. The rebels were held up at El Pino, Chihuahua, and at first Colonel Langhorne negotiated for the release of the two Americans and when this failed he ordered his men to embark his personal car and head for El Pino. Upon their arrival the Villistas fled and Deemer and Payne were freed. During the operation which ended on 21 May, five Mexicans were killed in skirmishes with no American losses.
President Wilson orders the National Guard to reinforce the United States Army garrisons at the border line. By August, an estimated 117,000 guardsmen were stationed along the border in Texas, New Mexico, Arizona and California.
On 12 April, American forces and Carrancistas fight the Battle of Parral in Chihuahua. When United States troops under MajorFrank Tompkins attempted to leave the city of Parral, they were attacked by Carrancista riflemen. The Americans returned fire, and over the course of several hours 45 Mexicans lay dead along with two Americans. The engagement marked the furthest penetration into northern Mexico by American forces, Parral is over 500 miles from the border.
In June, Buffalo Soldiers of the 10th Cavalry suffered a defeat at the Battle of Carrizal. Federal Mexican troops attacked 100 cavalrymen when they attempted to enter the town of Carrizal. The most famous battle of the Border war was fought and ended with the deaths of 45 Mexicans and 16 Americans. Forty-four other Mexicans and Americans were wounded.
Raids on American border towns continued during and for years after the Pancho Villa Expedition. On 15 June, raiders killed four American soldiers at San Ygnacio, Texas. On 31 July, another soldier and a United States customs inspector were killed in a second raid. During both engagements, Mexicans were killed or wounded but their casualties are not known.
Due to the defeat at Carrizal, President Wilson ordered General Pershing to withdraw from Mexico and end the expedition. By January, most of the American expeditionary troops had left Mexican territory and were back at garrison duty along the border.
United States Army Intelligence stationed at Fort Huachuca, Arizona, detected a German military presence in Sonora and ordered troops to begin surveillance operations to prepare for war with Mexico. Mexican railways, train stations, and other related enterprises were inspected as possible routes for a large-scale American invasion.
Revolutionary Yaquinative Americans established a base in Bear Valley, Arizona, to store weapons intended to be smuggled into Mexico. When the base was discovered by the United States Army, Blondy Ryder of the 10th Cavalry was ordered to evict the rebel Yaquis. On 9 January, Ryder's patrol attacked the Yaquis in a small half-hour engagement. The camp was destroyed, one Yaqui was killed, and nine others were captured. The United States Cavalry suffered no casualties.
In mid-August, Lieutenant Colonel Frederick J. Herman received an anonymous message from a Mexican revolutionary about a possible attack on Nogales, Arizona, by Mexican federal soldiers and a group of German military advisers. On 27 August, a Mexican suspected of gun smuggling crossed the border into Nogales, Sonora, followed by a US Customs agent and two US Army troops. A Mexican soldier watched the incident and fired on the American agent. The shot was a miss but hit one of the soldiers, and the other two Americans returned fire and killed the Mexican soldier.
From there, the incident escalated from a small dispute into the Battle of Ambos Nogales. Reinforcements from both sides rushed to the border to fight; men of the 35th Infantry Regiment called for aid, and a squadron of 10th Cavalry under Herman responded. When they arrived, they attacked the Mexican positions on top of hills along the other side of the border. The assault was successful and the Mexican troops with their German advisers were defeated. In all, 30-129 Mexicans, two Germans, and seven Americans died in the fighting. After the battle, German military activity in Sonora ceased. The Battle of Ambos Nogales was the last major engagement of the Border War.
American and Mexican forces skirmished near El Paso, Texas, on the border on 16 June in what was known as the Battle of Ciudad Juárez. This conflict is singular for the fact that the Mexican army and the American army joined forces to fight the Villistas led by Pancho Villa. It was the second-largest battle of the Mexican Revolution involving the United States, and is considered the last battle of the Border War.