Bornaviridae

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Family Bornaviridae
Virus classification
Group: Group V ((-)ssRNA)
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Species
  • Elapid 1 bornavirus
  • Mammalian 1 bornavirus
  • Passeriform 1 bornavirus
  • Passeriform 2 bornavirus
  • Psittaciform 1 bornavirus
  • Psittaciform 2 bornavirus
  • Waterbird 1 bornavirus
  • Variegated squirrel 1 bornavirus

Bornaviridae is a genus of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, and humans serve as natural hosts. Currently, eight species are included in one genus in this family. Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe; and proventricular dilatation disease in birds.[1][2]

Taxonomy[edit]

Family Bornaviridae: genus, species, and their viruses[3]
Genus Species Virus (Abbreviation)
Bornavirus Elapid 1 bornavirus Loveridge’s garter snake virus 1 (LGSV-1)
Mammalian 1 bornavirus* Borna disease virus 1 (BoDV-1)
Borna disease virus 2 (BoDV-2)
Passeriform 1 bornavirus canary bornavirus 1 (CnBV-1)
canary bornavirus 2 (CnBV-2)
canary bornavirus 3 (CnBV-3))
Passeriform 2 bornavirus estrildid finch bornavirus 1 (EsBV-1)
Psittaciform 1 bornavirus parrot bornavirus 1 (PaBV-1)
parrot bornavirus 2 (PaBV-2)
parrot bornavirus 3 (PaBV-3)
parrot bornavirus 4 (PaBV-4)
parrot bornavirus 7 (PaBV-7)
Psittaciform 2 bornavirus parrot bornavirus 5 (PaBV-5)
Waterbird 1 bornavirus aquatic bird bornavirus 1 (ABBV-1)
aquatic bird bornavirus 2 (ABBV-2)
Variegated squirrel 1 bornavirus Variegated squirrel 1 bornavirus (VSBV-1))

Table legend: "*" denotes type species.

Structure[edit]

Bornavirions are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. [1]

Genus Structure Symmetry Capsid Genomic Arrangement Genomic Segmentation
Bornavirus Spherical Enveloped Linear Monopartite

Life cycle[edit]

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering, with some alternative splicing mechanism, is the method of transcription. The virus exits the host cell by nuclear pore export. Horses, sheep, cattle, rodents, birds, and humans serve as the natural hosts. Transmission routes are fomite, contact, urine, feces, and saliva.[1]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Bornavirus Horses; sheep; cattle; rodents; birds; humans Neurons; astrocytes; oligodendrocytes; ependymal cells Clathrin-mediated endocytosis Budding Nucleus[4] Cytoplasm Fomites; contact: saliva; contact: urine; contact: feces

Pathogenicity[edit]

Between 2011 and 2013, three German breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. Genomic analysis found a previously unknown bornavirus in a contact squirrel and in brain tissue from the three men, the researchers reported, and it is the "likely causative agent" in their deaths. Prior to this, Bornavirus species were not thought to be responsible for human diseases.[5][6]

References[edit]

  1. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015. 
  2. ^ ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015. 
  3. ^ Afonso, Claudio L.; Amarasinghe, Gaya K.; Bányai, Krisztián; Bào, Yīmíng; Basler, Christopher F.; Bavari, Sina; Bejerman, Nicolás; Blasdell, Kim R.; Briand, François-Xavier (2016-08-01). "Taxonomy of the order Mononegavirales: update 2016". Archives of Virology. 161 (8): 2351–2360. doi:10.1007/s00705-016-2880-1. ISSN 1432-8798. PMC 4947412free to read. PMID 27216929. 
  4. ^ Veterinary Microbiology and microbial disease, 2nd edition, P J Quinn et al. Wiley-Blackwell
  5. ^ A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis
  6. ^ Zoonotic bornavirus from variegated squirrel tied to fatal CNS infections in German breeders.

External links[edit]