|in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India.|
Boswellia serrata is a plant that produces Indian frankincense, Salai, referred to in Sanskrit as shallaki and in Latin as Olibanum Indicum. the plant is native to much of India and the Punjab region that extends into Pakistan. Boswellia serrata Roxb., is also known as ‘Indian olibanum’, ‘Indian frankincense’, ‘dhup’ and ‘salai’ or ‘salai guggul’ is found in Eastern India.
Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo. Positive effects of Boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported. Some see Boswellia serrata as a promising alternative to NSAIDs, warranting further investigation in pharmacological studies and clinical trials. It is also used in Iranian traditional medicine for diabetes.
Boswellia serrata has been recently developed for topical use in a patent-pending formula in Sano Relief Gel. Boswellia serrata is used in the manufacture of the anti-wrinkle agent "Boswelox", which has been criticised as being ineffective.
Boswellia serrata contains chemical constituents mainly β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid. Acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-lipoxygenase enzyme inhibitor which is responsible for inflammation. AKBA is a compound associated with stopping 5-lipoxygenase (5-LOX) inflammation.
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- "The Effects of Boswellia serrata Gum Resin on the Blood Glucose and Lipid Profile of Diabetic Patients: A Double-Blind Randomized Placebo-Controlled Clinical Trial". doi:10.1177/2515690X18772728. PMID 29774768.
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- Dragos, Dorin; Gilca, Marilena; Gaman, Laura; Vlad, Adelina; Iosif, Liviu; Stoian, Irina; Lupescu, Olivera (2017-01-16). "Phytomedicine in Joint Disorders". Nutrients. 9 (1). doi:10.3390/nu9010070. ISSN 2072-6643. PMC . PMID 28275210.
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- Meka, B. Z. (Feb 2017). "Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities 7". Bioorganic & Medicinal Chemistry. 25 (4): 1374–1388. doi:10.1016/j.bmc.2016.12.045. PMID 28110820.