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Bottom-up may refer to:
- Bottom-up (finance), fundamental analysis beginning with specific businesses, regardless of their industry
- Bottom Up (company), a Japanese video game developer and publisher
- Bottom-up parsing, a computer science strategy
- Bottom-up proteomics, a laboratory technique involving proteins
- Bottom Up Records, the record label that released The Greatest Story Never Told and other albums
- Bottom-up testing, an approach to integrated testing where the lowest level components are tested first
- Top-down and bottom-up design, strategies of information processing and knowledge ordering
- Bottom-up approach of the Holocaust
- In sailing or boating, a capsize, turtling or turn turtle
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