The crew and label were established by Jamie Adenuga (born 4 May 1985). "Boy Better Know" also has a clothing line, and had a mobile network from 2011 to 2013.
Adenuga's debut album Famous? was released on the label in 2008. "Too Many Man", the first single from the album, was released on 25 May 2009. The song is also featured on the Wiley and Skepta albums, Race Against Time and Microphone Champion, respectively. The song was written because of Skepta's annoyance over 'the lack of women in clubs'. It entered the UK Singles Chart on 6 June 2009 at #97, reaching #79 the next week. The second single from the album V.I.P, titled "Goin' In", was released for download on iTunes on 13 December 2009.
JME's second studio album, Blam, was released 4 October 2010. Three singles from this album were released; "Over Me", "Sidetracked", which features Wiley, and "CD Is Dead" featuring UK grime artist Tempa T.
In 2008, Boy Better Know pioneered a short-lived dance fad called the "Rolex Sweep" which accompanied the song of the same name by Skepta.