Bradykinin receptor B1

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BDKRB1
Identifiers
AliasesBDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, Bradykinin receptor B1
External IDsMGI: 88144 HomoloGene: 570 GeneCards: BDKRB1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for BDKRB1
Genomic location for BDKRB1
Band14q32.2Start96,255,824 bp[1]
End96,268,967 bp[1]
RNA expression pattern
PBB GE BDKRB1 207510 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000710

NM_007539

RefSeq (protein)

NP_000701

NP_031565

Location (UCSC)Chr 14: 96.26 – 96.27 MbChr 12: 105.6 – 105.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[5]

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[6]

Antagonists[edit]

See also[edit]

References[edit]

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.