Default mode network

From Wikipedia, the free encyclopedia
  (Redirected from Brain fart)
Jump to: navigation, search
Graphs of the dynamic development of correlations between brain networks. (A) In children the regions are largely local and are organized by their physical location; the frontal regions are highlighted in light blue. (B) In adults the networks become highly correlated despite their physical distance; the default network is highlighted in light red.[1]
Default Mode Network Connectivity. This image shows main regions of the default mode network (yellow) and connectivity between the regions color-coded by structural traversing direction (xyz -> rgb).[2] [3]

In neuroscience, the default mode network (DMN), also called the default network or default state network, is a network of interacting brain regions that are known to be highly correlated with each other and distinct from other networks in the brain.[4] The default mode network is most commonly shown to be active when a person is not focused on the outside world and the brain is at wakeful rest such as during daydreaming and mind-wandering but it is also active when the individual is thinking about others, thinking about themselves, remembering the past, and planning for the future.[4] Though the DMN was originally noticed to be deactivated in certain goal-oriented tasks and is sometimes referred to as the task-negative network,[5] it can be active in other goal-oriented tasks such as social working memory or autobiographical tasks.[6] The DMN has been shown to be negatively correlated with other networks in the brain such as attention networks.[7] Evidence has pointed to disruptions in the DMN with people with Alzheimer’s and Autism Spectrum Disorder.[4]


The default mode network is known to be involved in many seemingly different functions:

Information regarding the self:[8]

  • Autobiographical information: Memories of collection of events and facts about one’s self
  • Self-reference: Referring to traits and descriptions of one’s self
  • Emotion of one’s self: Reflecting about one’s own emotional state

Thinking about others:[8]

  • Theory of Mind: Thinking about the thoughts of others and what they might or might not know
  • Emotions of other: Understanding the emotions of other people and empathizing with their feelings
  • Moral reasoning: Determining just and unjust result of an action
  • Social evaluations: Good-bad attitude judgments about social concepts
  • Social categories: Reflecting on important social characteristics and status of a group

Remembering that past and thinking about the future:[8]

  • Remembering the past: Recalling events that happened in the past
  • Imagining the future: Envisions events that might happen in the future
  • Episodic memory: Detailed memory related to specific event in time
  • Story comprehension: Understanding and remembering a narrative

The default mode network is active during passive rest and mind-wandering.[4] Mind-wandering usually involves thinking about others, thinking about one’s self, remembering about the past, and envisioning the future.[8] Electrocorticography studies (which involve placing electrodes on the surface of epileptic patient’s brains) have shown the default mode network becomes activated within an order of a fraction of a second after participants finish a task.[9]

Studies have shown when people watch a movie,[10] listen to a story[11] or reading a story,[12] their DMNs are highly correlated with each other. DMNs are not correlated if the stories are scrambled or in a language the person does not understand suggesting the network is highly involved comprehension and the subsequent memory formation of that story. The DMN is shown to even be correlated if the same story is presented to different people in different languages[13] further suggesting the DMN is truly involved in the comprehension aspect of the story and not the auditory or language aspect.

The default mode network is have shown to deactivate during external goal-oriented tasks such as visual attentions or cognitive working memory tasks thus leading some researchers to label the network as the task-negative network.[5] However, when the tasks are external goal-oriented tasks that are known to be a role of the DMN such as social working memory or an autobiographical task, the DMN is positively activated with the task and correlates with other networks such as the network involved in executive function.[6]


The default mode network is an interconnected and anatomically defined[4] set of brain regions. The network can be separated into hubs and subsections:

Functional Hubs:[14] Information regarding the self

  • Posterior Cingulate Cortex (PCC) & Precuneus: Combines bottom-up (not controlled) attention with information from memory and perception. The ventral (lower) part of PCC actives in all tasks which involve the DMN including those related to the self, related to others, remembering the past, thinking about future, and processing concepts plus spatial navigation. The dorsal (upper) part of PCC involves involuntary awareness and arousal. The precuenus is involved visual, sensorimotor, and attentional information.
  • Medial Prefrontal Cortex (mPFC): Decisions about self processing such as personal information, autobiographical memories, future goals and events, and decision making regarding those personally very close such as family. The ventral (lower) part is involved is positive emotional information and internally valued reward.
  • Angular Gyrus: Connects perception, attention, spatial cognition, and action and helps with parts of recall of episodic memories

Dorsal Medial Subsystem:[14] Thinking about others

Medial Temporal Subsystem:[14] Autobiographical memory and future simulations

The default mode network is most commonly defined with resting state data by putting a seed in the posterior cingulate cortex and examining which other brain areas most correlate with this area.[15] The DMN can also be defined by the areas deactivated during external directed tasks compared to rest.[16]

It has been shown that the default mode network exhibits the highest overlap in its structural and functional connectivity, which suggests that the structural architecture of the brain may be built in such a way that this particular network is activated by default.[17] In the infant brain, there is limited evidence of the default network, but default network connectivity is more consistent in children aged 9–12 years, suggesting that the default network undergoes developmental change.[7]


The default mode network has been hypothesized to be relevant to disorders including Alzheimer's disease, autism, schizophrenia, depression, chronic pain and others.[4] In particular, a failure to deactivate default network activity during cognitively demanding tasks is associated with autism,[18] overactivity with schizophrenia,[19] and the default network is preferentially attacked by the buildup of beta-amyloid in Alzheimer's disease.[20] Lower connectivity was found across the default network in people who have experienced long term trauma, such as childhood abuse. Among people experiencing posttraumatic stress disorder, lower activation was found in the posterior cingulate gyrus compared to controls.[21] Hyperconnectivity of the default network has been linked to rumination in depression[22] and chronic pain.[23]


The default mode network (DMN) may be modulated by the following interventions and processes:

  • Acupuncture - Deactivation of the limbic brain areas and the DMN.[24] Tactile control stimulation results in deactivation patterns that are considerably weaker and not statistically significant.[25]
  • Meditation - Structural changes in areas of the DMN such as the temporoparietal junction, posterior cingulate cortex, and precuneus have been found in meditation practitioners.[26] There is reduced activation and reduced functional connectivity of the DMN in long-term practitioners.[26]
  • Sleeping and resting wakefulness
    • Resting wakefulness - Functional connectivity between nodes of the DMN is strong.[27]
    • Onset of sleep - Decrease in connectivity between the DMN and the task-positive network.[27]
    • Stage N2 of NREM sleep - Decrease in connectivity between the posterior cingulate cortex and medial prefrontal cortex.[27]
    • Stage N3 of NREM sleep - Further decrease in connectivity between the PCC and MPFC.[27]
    • REM sleep - Possible increase in connectivity between nodes of the DMN.[27]
  • Sleep deprivation - Functional connectivity between nodes of the DMN in their resting-state is usually strong, but sleep deprivation results in a decrease in connectivity within the DMN.[28] Recent studies suggest a decrease in connectivity between the DMN and the task-positive network as a result of sleep loss.[29]
  • Psychedelic drugs - Reduced blood flow to the PCC and mPFC were observed under the administration of psilocybin. These two areas are believed to be involved in the DMN.[30]


Hans Berger, the inventor of the electroencephalogram, was the first to propose the idea that the brain is constantly busy. In a series of papers published in 1929 he showed that the electrical oscillations detected by his device do not cease even when the subject is at rest. However, his ideas were not taken seriously, and a general perception formed among neurologists that only when a focused activity is performed does the brain (or a part of the brain) become active.[31] In 1950’s to the surprise of the researchers, Louis Sokoloff and his colleagues noticed metabolism in the brain stayed the same when a person went from a resting state to performing effortful math problems suggesting active metabolism in the brain must also be happening during rest.[4] In the 1970s, Ingvar and colleagues observed blood flow in the front part of the brain became the highest when a person is at rest.[4] Around the same time, intrinsic oscillatory behavior in vertebrate neurons was observed in cerebellar Purkinje cells, inferior olivary nucleus and thalamus.[32]

In the 1990’s with the advent of PET scans, researchers began to notice when a person is involved in perception, language, and attention tasks the same brain areas become less active compare to passive rest, labeling these areas as becoming “deactivated”.[4] Later, experiments by neurologist Marcus E. Raichle's lab at Washington University School of Medicine and other groups showed that the brain's energy consumption is increased by less than 5% of its baseline energy consumption while performing a focused mental task. These experiments showed that the brain is constantly active with a high level of activity even when the person is not engaged in focused mental work. Research thereafter focused on finding the regions responsible for this constant background activity level.[31]

Raichle coined the term "default mode" in 2001 to describe resting state brain function;[16] the concept rapidly became a central theme in neuroscience.[33] Around this time the idea was implanted that this network of brain areas is involved in internally directed thoughts and is suspended during specific goal-directed behaviors. In 2003, Greicius and colleagues examined resting state fMRI scans and looked at how correlated different sections in the brain are to each other and found the correlation maps showed the same areas Raichle found active during rest and that others found to deactivated.[15] It was important because it demonstrated a convergence of methods all lead to the same areas being involved in the DMN. Since then other Resting State Networks (RSNs) have been found, such as visual, auditory, and attention networks, some of them are often anti-correlated with the default mode network.[7]

In the beginning to mid 2000s, researches labeled the default mode network as the task negative network[5] because it was deactivated when participants had to perform tasks. DMN was thought to only be active during passive rest and then turned off during externally focused goal-directed tasks. However, studies have demonstrated the DMN to be active in external goal-directed tasks which is known to involve the DMN such as social working memory or autobiographical tasks.[6]

Around 2007, the number of papers referencing the default mode network have skyrocketed.[8] All years prior to 2007, there were 12 papers published that referenced “default mode network” or “default network” in the title, however, between 2007 and 2014 there were 1384 papers published. One reason for the increase in papers is a result of the robust effect of finding the DMN with resting state scans. Another reason is the DMN can be measured with a short and effortless resting state scans meaning they can be performed on any population including young children, clinical populations, and nonhuman primates.[4] A third reason is role of the DMN has been expanded to more than just a passive brain network.


Some have argued the brain areas in the default mode network only show up together because of the vascular coupling of large arteries and veins in the brain near these areas, not because these areas are actually functional connected to each other. Support for this argument comes from studies that show changing in breathing alters oxygen levels in the blood which in turns affects DMN the most.[4] These studies however do not explain why the DMN can also be identified using PET scans by measuring glucose metabolism which is independent of vascular coupling[4] or in electrocorticography studies[34] measuring electrical activity on the surface the brain.

The idea of a "default network" is not universally accepted.[35] In 2007 the concept of the default mode was criticized as not being useful for understanding brain function, on the grounds that a simpler hypothesis is that a resting brain actually does more processing than a brain doing certain "demanding" tasks, and that there is no special significance to the intrinsic activity of the resting brain.[36]


  1. ^ Fair, Damien A.; Cohen, Alexander L.; Power, Jonathan D.; Dosenbach, Nico U. F.; Church, Jessica A.; Miezin, Francis M.; Schlaggar, Bradley L.; Petersen, Steven E. (2009). Sporns, Olaf, ed. "Functional Brain Networks Develop from a 'Local to Distributed' Organization". PLoS Computational Biology 5 (5): e1000381. doi:10.1371/journal.pcbi.1000381. PMC 2671306. PMID 19412534. 
  2. ^ Horn, Andreas; Ostwald, Dirk; Reisert, Marco; Blankenburg, Felix (2013). "The structural-functional connectome and the default mode network of the human brain". NeuroImage 102: 142–151. doi:10.1016/j.neuroimage.2013.09.069. PMID 24099851. 
  3. ^ Garrity, A.; Pearlson, G. D.; McKiernan, K.; Lloyd, D.; Kiehl, K. A.; Calhoun, V. D. (2007). "Aberrant default mode functional connectivity in schizophrenia". Am.J.Psychiatry 164: 450–457. doi:10.1176/ajp.2007.164.3.450. 
  4. ^ a b c d e f g h i j k l Buckner, R. L.; Andrews-Hanna, J. R.; Schacter, D. L. (2008). "The Brain's Default Network: Anatomy, Function, and Relevance to Disease". Annals of the New York Academy of Sciences 1124 (1): 1–38. doi:10.1196/annals.1440.011. PMID 18400922. 
  5. ^ a b c Fox, Michael D.; Snyder, Abraham Z.; Vincent, Justin L.; Corbetta, Maurizio; Van Essen, David C.; Raichle, Marcus E. (2005-07-05). "The human brain is intrinsically organized into dynamic, anticorrelated functional networks". Proceedings of the National Academy of Sciences of the United States of America 102 (27): 9673–9678. doi:10.1073/pnas.0504136102. ISSN 0027-8424. PMC 1157105. PMID 15976020. 
  6. ^ a b c Spreng, R. Nathan (2012-01-01). "The fallacy of a "task-negative" network". Frontiers in Psychology 3: 145. doi:10.3389/fpsyg.2012.00145. ISSN 1664-1078. PMC 3349953. PMID 22593750. 
  7. ^ a b c Broyd, Samantha J.; Demanuele, Charmaine; Debener, Stefan; Helps, Suzannah K.; James, Christopher J.; Sonuga-Barke, Edmund J.S. (2009). "Default-mode brain dysfunction in mental disorders: A systematic review". Neuroscience & Biobehavioral Reviews 33 (3): 279–96. doi:10.1016/j.neubiorev.2008.09.002. PMID 18824195. 
  8. ^ a b c d e Andrews-Hanna, Jessica R. (2012-06-01). "The brain's default network and its adaptive role in internal mentation". The Neuroscientist: A Review Journal Bringing Neurobiology, Neurology and Psychiatry 18 (3): 251–270. doi:10.1177/1073858411403316. ISSN 1089-4098. PMC 3553600. PMID 21677128. 
  9. ^ Dastjerdi, Mohammad; Foster, Brett L.; Nasrullah, Sharmin; Rauschecker, Andreas M.; Dougherty, Robert F.; Townsend, Jennifer D.; Chang, Catie; Greicius, Michael D.; Menon, Vinod (2011-02-15). "Differential electrophysiological response during rest, self-referential, and non-self-referential tasks in human posteromedial cortex". Proceedings of the National Academy of Sciences of the United States of America 108 (7): 3023–3028. doi:10.1073/pnas.1017098108. ISSN 1091-6490. PMC 3041085. PMID 21282630. 
  10. ^ Hasson, Uri; Furman, Orit; Clark, Dav; Dudai, Yadin; Davachi, Lila (2008-02-07). "Enhanced intersubject correlations during movie viewing correlate with successful episodic encoding". Neuron 57 (3): 452–462. doi:10.1016/j.neuron.2007.12.009. ISSN 0896-6273. PMC 2789242. PMID 18255037. 
  11. ^ Lerner, Yulia; Honey, Christopher J.; Silbert, Lauren J.; Hasson, Uri (2011-02-23). "Topographic mapping of a hierarchy of temporal receptive windows using a narrated story". The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 31 (8): 2906–2915. doi:10.1523/JNEUROSCI.3684-10.2011. ISSN 1529-2401. PMC 3089381. PMID 21414912. 
  12. ^ Regev, Mor; Honey, Christopher J.; Simony, Erez; Hasson, Uri (2013-10-02). "Selective and invariant neural responses to spoken and written narratives". The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 33 (40): 15978–15988. doi:10.1523/JNEUROSCI.1580-13.2013. ISSN 1529-2401. PMC 3787506. PMID 24089502. 
  13. ^ Honey, Christopher J.; Thompson, Christopher R.; Lerner, Yulia; Hasson, Uri (2012-10-31). "Not lost in translation: neural responses shared across languages". The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 32 (44): 15277–15283. doi:10.1523/JNEUROSCI.1800-12.2012. ISSN 1529-2401. PMC 3525075. PMID 23115166. 
  14. ^ a b c Andrews-Hanna, Jessica R.; Smallwood, Jonathan; Spreng, R. Nathan (2014-05-01). "The default network and self-generated thought: component processes, dynamic control, and clinical relevance". Annals of the New York Academy of Sciences 1316 (1): 29–52. doi:10.1111/nyas.12360. ISSN 1749-6632. PMC 4039623. PMID 24502540. 
  15. ^ a b Greicius, Michael D.; Krasnow, Ben; Reiss, Allan L.; Menon, Vinod (2003-01-07). "Functional connectivity in the resting brain: a network analysis of the default mode hypothesis". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 253–258. doi:10.1073/pnas.0135058100. ISSN 0027-8424. PMC 140943. PMID 12506194. 
  16. ^ a b Raichle, M. E.; MacLeod, AM; Snyder, AZ; Powers, WJ; Gusnard, DA; Shulman, GL (2001). "Inaugural Article: A default mode of brain function". Proceedings of the National Academy of Sciences 98 (2): 676–82. doi:10.1073/pnas.98.2.676. PMC 14647. PMID 11209064. 
  17. ^ Horn A, Ostwald D, Reisert M, Blankenburg F; Blankenburg (2013). "The structural-functional connectome and the default mode network of the human brain". NeuroImage 13: 1053–8119. doi:10.1016/j.neuroimage.2013.09.069. PMID 24099851. 
  18. ^ Kennedy, DP; Redcay, E; Courchesne, E (2006). "Failing to deactivate: resting functional abnormalities in autism". Proc. Natl. Acad. Sci. USA 103 (21): 8275–8280. doi:10.1073/pnas.0600674103. PMC 1472462. PMID 16702548. 
  19. ^ Whitfield-Gabrieli, S.; Thermenos, H. W.; Milanovic, S.; Tsuang, M. T.; Faraone, S. V.; McCarley, R. W.; Shenton, M. E.; Green, A. I.; et al. (2009). "Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia". Proceedings of the National Academy of Sciences 106 (4): 1279–84. doi:10.1073/pnas.0809141106. PMC 2633557. PMID 19164577. 
  20. ^ Kolata G (2010-12-13). "Insights give hope for new attack on Alzheimer's". New York Times. Retrieved 2010-12-14. 
  21. ^ Dr. Ruth Lanius, Brain Mapping conference, London, November 2010)
  22. ^ Zhu, X; Wang, X; Xiao, J; Liao, J; Zhong, M; Wang, W; Yao, S (2012). "Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients". Biological Psychiatry 71 (7): 611–7. doi:10.1016/j.biopsych.2011.10.035. PMID 22177602. 
  23. ^ Kucyi, A; Moayedi, M; Weissman-Fogel, I; Goldberg, M. B.; Freeman, B. V.; Tenenbaum, H. C.; Davis, K. D. (2014). "Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination". Journal of Neuroscience 34 (11): 3969–75. doi:10.1523/JNEUROSCI.5055-13.2014. PMID 24623774. 
  24. ^ Huang, Wenjing; Pach, Daniel; Napadow, Vitaly; Park, Kyungmo; Long, Xiangyu; Neumann, Jane; Maeda, Yumi; Nierhaus, Till; Liang, Fanrong; Witt, Claudia M.; Harrison, Ben J. (9 April 2012). "Characterizing Acupuncture Stimuli Using Brain Imaging with fMRI - A Systematic Review and Meta-Analysis of the Literature". PLOS ONE 7 (4): e32960. doi:10.1371/journal.pone.0032960. 
  25. ^ Chae, Younbyoung; Chang, Dong-Seon; Lee, Soon-Ho; Jung, Won-Mo; Lee, In-Seon; Jackson, Stephen; Kong, Jian; Lee, Hyangsook; Park, Hi-Joon; Lee, Hyejung; Wallraven, Christian. "Inserting Needles Into the Body: A Meta-Analysis of Brain Activity Associated With Acupuncture Needle Stimulation". The Journal of Pain 14 (3): 215–222. doi:10.1016/j.jpain.2012.11.011. 
  26. ^ a b Fox, Kieran C.R.; Nijeboer, Savannah; Dixon, Matthew L.; Floman, James L.; Ellamil, Melissa; Rumak, Samuel P.; Sedlmeier, Peter; Christoff, Kalina. "Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners". Neuroscience & Biobehavioral Reviews 43: 48–73. doi:10.1016/j.neubiorev.2014.03.016. 
  27. ^ a b c d e Picchioni, Dante; Duyn, Jeff H.; Horovitz, Silvina G. "Sleep and the functional connectome". NeuroImage (journal) 80: 387–396. doi:10.1016/j.neuroimage.2013.05.067. 
  28. ^ McKenna, Benjamin S.; Eyler, Lisa T. "Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: A review of functional neuroimaging studies". Clinical Psychology Review 32 (7): 650–663. doi:10.1016/j.cpr.2012.07.003. PMC 3922056. PMID 22926687. 
  29. ^ Basner, Mathias; Rao, Hengyi; Goel, Namni; Dinges, David F. "Sleep deprivation and neurobehavioral dynamics". Current Opinion in Neurobiology 23 (5): 854–863. doi:10.1016/j.conb.2013.02.008. 
  30. ^ Carhart-Harris, Robin L.; Erritzoe, David; Williams, Tim; Stone, James M.; Reed, Laurence J.; Colasanti, Alessandro; Tyacke, Robin J.; Leech, Robert; Malizia, Andrea L.; Murphy, Kevin; Hobden, Peter; Evans, John; Feilding, Amanda; Wise, Richard G.; Nutt, David J. "Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin". PNAS 109 (6): 2138–2143. doi:10.1073/pnas.1119598109. PMC 3277566. PMID 22308440. 
  31. ^ a b Raichle, Marcus (March 2010). "The Brain's Dark Energy". Scientific American: 44–49. 
  32. ^ Llinas, R. R. (2014). "Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective". Front Cell Neurosci 8: 320. doi:10.3389/fncel.2014.00320. PMC 4219458. PMID 25408634. 
  33. ^ Raichle, Marcus E.; Snyder, Abraham Z. (2007). "A default mode of brain function: A brief history of an evolving idea". NeuroImage 37 (4): 1083–90. doi:10.1016/j.neuroimage.2007.02.041. PMID 17719799. 
  34. ^ Foster, Brett L.; Parvizi, Josef (2012-03-01). "Resting oscillations and cross-frequency coupling in the human posteromedial cortex". NeuroImage 60 (1): 384–391. doi:10.1016/j.neuroimage.2011.12.019. ISSN 1095-9572. PMC 3596417. PMID 22227048. 
  35. ^ Fair, D. A.; Cohen, A. L.; Dosenbach, N. U. F.; Church, J. A.; Miezin, F. M.; Barch, D. M.; Raichle, M. E.; Petersen, S. E.; Schlaggar, B. L. (2008). "The maturing architecture of the brain's default network". Proceedings of the National Academy of Sciences 105 (10): 4028–32. doi:10.1073/pnas.0800376105. PMC 2268790. PMID 18322013. 
  36. ^ Morcom, Alexa M.; Fletcher, Paul C. (2007). "Does the brain have a baseline? Why we should be resisting a rest". NeuroImage 37 (4): 1073–1082. doi:10.1016/j.neuroimage.2006.09.013. 

External links[edit]