From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
BrainsWay Ltd.
IndustryMedical technology
Founded2003 (2003)
FounderUzi Sofer
Avner Hagai (President)
David Zacut (Chairman)
Key people

Abraham Zangen
Yiftach Roth
ProductsDeep TMS System
ServicesBrain Disorder treatment
SubsidiariesBrainsway Inc.

BrainsWay (Hebrew: בריינסוויי‎) is an Israeli company with international operations that is engaged in the development of a medical device that uses H-coil for deep transcranial magnetic stimulation (Deep TMS) as a noninvasive treatment for depression. The company was founded in 2003 and has offices in the US and Jerusalem, Israel.


The magnetic coil technology used by Brainsway's devices, called the "H coil", emerged from research done in the late 1990s and early 2000s at the U.S. National Institutes of Health (NIH) by Abraham Zangen, Roy A. Wise, Mark Hallett, Pedro C. Miranda and Yiftach Roth.[1][2][3] Most coils used in transcranial magnetic stimulation (TMS) provide a shallow magnetic field that affects neurons mostly on the surface of the brain, delivered with coil shaped like the number eight. The H coil provided magnetic fields deeper in the brain, and devices using them provide what is called "deep TMS".[4] The H-coil was patented by the NIH in 2002, and the procedure whereby the H-coil was applied to TMS became known as Deep TMS.[3][5][6]

BrainsWay was founded in 2003 in Delaware by Uzi Sofer and Avner Hagai, together with David Zacut and they set up a subsidiary in Jerusalem,[3] and obtained an exclusive license from the NIH for patent it filed on the H coil.[7] By 2006 the company had conducted animal studies at Weizmann Institute of Science and had run its first clinical trial assessing safety, at Tel Aviv University.[3]

In early 2007 BrainsWay executed an initial public offering on the Tel Aviv Stock Exchange, raising 33 million for a market cap of ₪110 million.[8] In 2010 Brainsway announced plans to list shares of the company's stock on the Nasdaq exchange but withdrew them in June.[9][10]

In January 2013, BrainsWay received clearance from the U.S. Food and Drug Administration and from Health Canada to market its deep TMS device in the United States and in Canada as a treatment for treatment-resistant major depressive disorder.[11][12] Evidence to support this use is tentative as of 2013 no high quality evidence is available.[4]

See also[edit]


  1. ^ George, Mark S. (September 2003). "Stimulating the Brain". Scientific American. 289 (3): 66–73. doi:10.1038/scientificamerican0903-66.
  2. ^ Rapp, David (17 February 2005). "Field of Dreams". Haaretz.
  3. ^ a b c d Blackburn, Nicky (19 February 2006). "Israel's Brainsway stimulates a magnetic remedy for depression". Israel21c. Retrieved 11 January 2013.
  4. ^ a b Bersani, FS; Minichino, A; Enticott, PG; Mazzarini, L; Khan, N; Antonacci, G; Raccah, RN; Salviati, M; Delle Chiaie, R; Bersani, G; Fitzgerald, PB; Biondi, M (January 2013). "Deep transcranial magnetic stimulation as a treatment for psychiatric disorders: a comprehensive review". European Psychiatry. 28 (1): 30–9. doi:10.1016/j.eurpsy.2012.02.006. PMID 22559998. open access
  5. ^ Spronk, Desirée; Arns, Martijn; Fitzgerald, Paul B. (2011). "Chapter 10: Repetitive Transcranial Magnetic Stimulation in Depression: Protocols, Mechanisms, and New Developments". In Coben, Robert; Evans, James R. (eds.). Neurofeedback and Neuromodulation Techniques and Applications. London: Academic Press. pp. 278–279. ISBN 978-0-12-382235-2. Retrieved 11 January 2013.
  6. ^ Heller, Corinne (7 December 2006). "Scientists in Israel are reaching deeper into the minds of the clinically depressed to try to lift their spirits". Reuters. Retrieved 11 January 2013.
  7. ^ "Magnetic Stimulation Shows Promise as the New Wave for Treating Depression". NIH Office of Technology Transfer. 24 July 2007. Archived from the original on 30 March 2013.
  8. ^ Weinreb, Gali (2 January 2007). "Brainsway IPO four times oversubscribed". Globes. Archived from the original on 21 January 2010. Retrieved 11 January 2013.
  9. ^ Habib-Valdhorn, Shiri (8 August 2010). "Brainsway looks to Nasdaq offering". Globes. Archived from the original on 17 February 2013. Retrieved 11 January 2013.
  10. ^ "Brainsway withdraws IPO". Renaissance Capital. 14 June 2011. Retrieved 11 January 2013.
  11. ^ Wainer, Davic (9 January 2013). "Brainsway Rises as U.S. Allows Depression Device: Tel Aviv Mover". Bloomberg. Retrieved 11 January 2013.
  12. ^ "Health Canada approves Brainsway depression therapy". Globes. 15 January 2013. Archived from the original on 18 February 2013. Retrieved 26 January 2013.

Further reading[edit]

  • Hallett, Mark (19 July 2007). "Transcranial Magnetic Stimulation: A Primer". Neuron. 55 (2): 187–199. doi:10.1016/j.neuron.2007.06.026.
  • Roth, Yiftach; Zangen, Abraham (2012). "Basic Principles and Methodological Aspects of Transcranial Magnetic Stimulation". In Miniussi, Carlo; Paulus, Walter; Rossini, Paolo M. (eds.). Transcranial Brain Stimulation. CRC Press. ISBN 978-1-43-987570-4.