C. aperea has been successfully mated to the domestic guinea pig, Cavia porcellus, though many females become infertile in successive generations. Brazilian guinea pigs are nocturnal animals. They are narrower and longer than domesticated guinea pigs.
^Dunnum, J., Zeballos, H., Vargas, J., Bernal, N., Brito, D., Queirolo, D., Pardinas, U. & D'Elia, G. (2008). Cavia aperea. In: IUCN 2008. IUCN Red List of Threatened Species. Retrieved 5 January 2009.
^Weir, Barbara J. (1974), "Notes on the Origin of the Domestic Guinea-Pig", in Rowlands, I. W.; Weir, Barbara J., The Biology of Hystricomorph Rodents, Academic Press, pp. pp. 437–446, ISBN0-12-613334-4