Brendan Q. Ferguson began his career as a programmer at LucasArts in 2003 on Star Wars: Obi-Wan. He was a co-writer and co-designer of the cancelled Sam & Max Freelance Police. He left LucasArts with much of the Freelance Police team in 2004 to join Telltale Games. He maintained their blog in their early years and was as a co-designer of their first game, Telltale Texas Hold'em. He was also the voice of Theodore Dudebrough in that game. Between 2006 and 2007, he co-designed and co-wrote Sam & Max Save the World. In 2007 and 2008, he also the co-designed and co-wrote the sequel, Sam & Max Beyond Time and Space. He reprised his role as voice actor in those games, voicing the bug. His final project at Telltale Games was writing the episode The Tomb of Sammun-Mak for Sam & Max: The Devil's Playhouse, before leaving Telltale Games in 2010.
Sam & Max Beyond Time & Space, which was co-designed and co-written by Ferguson, received awards in the 2008 Adventure Gamers Aggie Awards in the categories of "Best Writing", "Best Gameplay", "Best Third-Person PC Adventure", and "Best Adventure of 2008".
Tales of Monkey Island, for which Brendan Q. Furguson co-developed episodes 1–4, was nominated for "best artistic design" and won for the award for "biggest surprise" at IGN's Best of E3 2009 Awards. After release, it won the PC Gamer 2009 adventure game of the year, was nominated for the IGN best adventure game of the year for PC and Wii, won the Adventure Gamers Best Adventure of 2009, and was named the "Best Series Revival" by OC Weekly.