Brenner tumour

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Brenner tumor
Brenner Tumor of Ovary.jpg
A Brenner tumor of ovary (gross image).
Classification and external resources
Specialty gynecologic oncology
ICD-9-CM 220
ICD-O 9000
DiseasesDB 33431
MeSH D001948

Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.[1]

They are most frequently found incidentally on pelvic examination or at laparotomy.[2] Brenner tumours very rarely can occur in other locations, including the testes.[3]


On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.


Micrograph of a Brenner tumour. H&E stain.
High magnification micrograph of a Brenner tumour showing the characteristic coffee bean nuclei. H&E stain.

Histologically, there are nests of transitional epithelial (urothelial) cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.

Similar conditions[edit]

Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.


It is named for Fritz Brenner (1877–1969), a German surgeon who characterized it in 1907.[4] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[5]

Additional images[edit]


  1. ^ Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (2005). "Malignant Brenner tumour--a case report". Indian J Pathol Microbiol. 48 (2): 251–2. PMID 16758686. 
  2. ^ Green GE, Mortele KJ, Glickman JN, Benson CB (2006). "Brenner tumors of the ovary: sonographic and computed tomographic imaging features". J Ultrasound Med. 25 (10): 1245–51; quiz 1252–4. PMID 16998096. 
  3. ^ Caccamo D, Socias M, Truchet C (1991). "Malignant Brenner tumor of the testis and epididymis". Arch. Pathol. Lab. Med. 115 (5): 524–7. PMID 2021324. 
  4. ^ Lamping JD, Blythe JG (1977). "Bilateral Brenner tumors: a case report and review of the literature". Hum. Pathol. 8 (5): 583–5. doi:10.1016/S0046-8177(77)80117-2. PMID 903146. 
  5. ^ Philipp, Elliot Elias; O'Dowd, Michael J. (2000). The history of obstetrics and gynaecology. Carnforth, Lancs: Parthenon. p. 586. ISBN 1-85070-040-0. 

External links[edit]