Brevican

From Wikipedia, the free encyclopedia
Jump to: navigation, search
BCAN
Identifiers
Aliases BCAN, BEHAB, CSPG7, Brevican
External IDs MGI: 1096385 HomoloGene: 7244 GeneCards: 63827
RNA expression pattern
PBB GE BCAN 219107 at tn.png

PBB GE BCAN 221623 at tn.png

PBB GE BCAN 91920 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021948
NM_198427

NM_001109758
NM_007529

RefSeq (protein)

NP_068767.3
NP_940819.1

NP_001103228.1
NP_031555.2

Location (UCSC) Chr 1: 156.64 – 156.66 Mb Chr 3: 87.99 – 88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Brevican core protein is a protein that in humans is encoded by the BCAN gene.[1][2][3] Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain.[4] In melanocytic cells, BCAN gene expression may be regulated by MITF.[5]

References[edit]

  1. ^ Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene 256 (1-2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543. 
  2. ^ Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama 56 (1): 25–9. PMID 11873941. 
  3. ^ "Entrez Gene: BCAN brevican". 
  4. ^ Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913. 
  5. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]