Brodmann area 43, the subcentral area, is a structurally distinct area of the cerebral cortex defined on the basis of cytoarchitecture. Along with Brodmann Area 1, 2, and 3, Brodmann area 43 is a subdivision of the postcentral region of the brain. The histological structure of Area 43 was initially described by Korbinian Brodmann, but it was not labeled on his map of cortical areas.
Additionally, Brodmann Area 43 was found to be functionally active in a study differentiating the roles of the left-frontal and right-cerebellar regions during semantic analysis. Broadmann Area 43 showed a major increase in functional activation by fMRI, when study participants were asked to complete tasks which involved the selection of a verbal response from many possible responses, rather than a sustained search for a verbal response from few possible responses.
Brodmann initially believed there to be no distinct Area 43 in his map of the lower monkey, the guenon. However, study of the myeloarchitecture of the region, by Theodor Mauss, determined that monkeys possess a structurally distinct area corresponding to the human subcentral area. It was regarded as cytoarchitecturally homologous to A rea 30 of Mauss in 1908. However, research by Cécile and Oskar Vogt found no distinctive architectonic area of the corresponding location in the guenon.