Bromadoline

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Bromadoline
Bromadoline.svg
Clinical data
SynonymsBromadoline
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC15H21BrN2O
Molar mass325.244 g/mol g·mol−1
3D model (JSmol)
ChiralityRacemate of trans isomers
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Bromadoline (U-47931E)[1] is an opioid analgesic selective for the μ-opioid receptor[2] developed by the Upjohn company in the 1970s.[3]The drug has a potency lying between that of codeine and morphine, being slightly stronger than pentazocine.[4] Bromadoline is related to AH-7921 and U-47700.[5]

See also[edit]

References[edit]

  1. ^ Unlisted Drugs. 34–35. Chatham: Pharmaceutical Section, Special Libraries Association. 1982. p. 392. ISBN 978-0-913210-13-0.
  2. ^ Hayes, A. G.; Skingle, M.; Tyers, M. B. (1 March 1987). "Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine". Journal of Pharmacology and Experimental Therapeutics. 240 (3): 984–988. ISSN 1521-0103. PMID 3559988.
  3. ^ Jacob Szmuszkovicz (4 July 1978). "Patent US4098904 - Analgesic N-(2-aminocycloaliphatic)benzamides". The Upjohn Company.
  4. ^ Hayes, A.g.; Sheehan, M.j.; Tyers, M.b. (August 1987). "Differential sensitivity of models of antinociception in the rat, mouse and guinea-pig to μ-and κ-opioid receptor agonists". British Journal of Pharmacology. 91 (4): 823–832. doi:10.1111/j.1476-5381.1987.tb11281.x. PMC 1853585. PMID 2822190.
  5. ^ B. Vernon Cheney; Jacob Szmuszkovicz; Robert A. Lahti; Dominic A. Zichi (December 1985). "Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor". Journal of Medicinal Chemistry. 28 (12): 1853–1864. doi:10.1021/jm00150a017. PMID 2999404.