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|AHFS/Drugs.com||International Drug Names|
|Elimination half-life||12 hr|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||376.136 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus. It was originally derived as an extract derivative called vasicinone from the Indian plant, Adhatoda vasica.
It was patented in 1961 and came into medical use in 1966.
Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect, allowing the cilia to more easily transport the phlegm out of the lungs. For this reason it is often added to cough syrups.
It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".
Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.
- Benadryl Chesty/Forte
- Brofentol Plus
- Broncholyte Elixir
- Duro-Tuss Chesty/Forte
- Robitussin Chesty/Forte
- Ventilate Forte (combination of bromhexine and salbutamol)
- Morton I, Hall J (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
- Zanasi, Alessandro; Mazzolini, Massimiliano; Kantar, Ahmad (2017-03-20). "A reappraisal of the mucoactive activity and clinical efficacy of bromhexine". Multidisciplinary Respiratory Medicine. 12 (1). doi:10.1186/s40248-017-0088-1. ISSN 2049-6958. PMC 5359817. PMID 28331610.
- Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.