|Name, symbol||bromine, Br|
|Pronunciation||// or //
BROH-meen or BROH-min
solid: metallic luster
|Bromine in the periodic table|
|Atomic number (Z)||35|
|Group, block||group 17 (halogens), p-block|
|Element category||diatomic nonmetal|
|Standard atomic weight (Ar)||79.904 (79.901–79.907)|
|Electron configuration||[Ar] 3d10 4s2 4p5|
|2, 8, 18, 7|
|Melting point||265.8 K (−7.2 °C, 19 °F)|
|Boiling point||332.0 K (58.8 °C, 137.8 °F)|
|Density near r.t.||Br2, liquid: 3.1028 g/cm3|
|Triple point||265.90 K, 5.8 kPa|
|Critical point||588 K, 10.34 MPa|
|Heat of fusion||(Br2) 10.571 kJ/mol|
|Heat of vaporization||(Br2) 29.96 kJ/mol|
|Molar heat capacity||(Br2) 75.69 J/(mol·K)|
|Oxidation states||7, 5, 4, 3, 1, −1 (a strongly acidic oxide)|
|Electronegativity||Pauling scale: 2.96|
|Ionization energies||1st: 1139.9 kJ/mol
2nd: 2103 kJ/mol
3rd: 3470 kJ/mol
|Atomic radius||empirical: 120 pm|
|Covalent radius||120±3 pm|
|Van der Waals radius||185 pm|
|Speed of sound||206 m/s (at 20 °C)|
|Thermal conductivity||0.122 W/(m·K)|
|Electrical resistivity||7.8×1010 Ω·m (at 20 °C)|
|Discovery and first isolation||Antoine Jérôme Balard and Leopold Gmelin (1825)|
|Most stable isotopes of bromine|
Bromine (from Ancient Greek: βρῶμος, brómos, meaning "stench") is a chemical element with symbol Br and atomic number 35. It is a halogen. The element was isolated independently by two chemists, Carl Jacob Löwig (in 1825) and Antoine Jérôme Balard (in 1826). Elemental bromine is a fuming red-brown liquid at room temperature, corrosive and toxic, with properties between those of chlorine and iodine. Bromine does not occur free in nature, but in colorless soluble crystalline mineral halide salts, analogous to table salt.
Bromine is rarer than about three-quarters of elements in the Earth's crust. The high solubility of bromide ions has caused its accumulation in the oceans, and commercially the element is easily extracted from brine pools, mostly in the United States, Israel and China. About 556,000 tonnes were produced in 2007, an amount similar to the far more abundant element magnesium.
At high temperatures, organobromine compounds readily convert to free bromine atoms, a process that stops free radical chemical chain reactions. This effect makes organobromine compounds useful as fire retardants and more than half the bromine produced worldwide each year is put to this purpose. Unfortunately, the same property causes sunlight to convert volatile organobromine compounds to free bromine atoms in the atmosphere, causing ozone depletion. As a result, many organobromide compounds that were formerly in common use—such as the pesticide methyl bromide—are discontinued. Bromine compounds are still used in well drilling fluids, in photographic film, and as an intermediate in the manufacture of organic chemicals.
Bromine has long been considered to be possibly essential in humans, but with the support of only limited circumstantial evidence, and no clear biological role. However, one recent study has purportedly identified an essential role in a key protein. Bromine is used preferentially to chlorine by one antiparasitic enzyme in the human immune system. Organobromides are needed and produced from bromide by some lower life forms in the sea, particularly algae, and the ash of seaweed was one source of bromine's discovery. As a pharmaceutical, the simple bromide ion (Br−) has inhibitory effects on the central nervous system, and bromide salts were once a major medical sedative, before replacement by shorter-acting drugs. They retain niche uses as antiepileptics.
- 1 Characteristics
- 2 History
- 3 Occurrence
- 4 Production
- 5 Compounds and chemistry
- 6 Applications
- 7 Biological role
- 8 Safety
- 9 See also
- 10 References
- 11 External links
The element bromine exists as a diatomic molecule, Br2. It is a dense, mobile, slightly transparent reddish-brown liquid that evaporates easily at standard temperature and pressures to give an orange vapor (its color resembles nitrogen dioxide) that has a strongly disagreeable odor resembling that of chlorine. It is one of only two chemical elements that are liquid at room temperature (mercury is the other, although caesium, gallium, and rubidium melt just above room temperature).
At a pressure of 55 GPa (roughly 540,000 times atmospheric pressure) bromine undergoes insulator-to-metal transition. At 75 GPa it changes to a face centered orthorhombic structure. At 100 GPa it changes to a body centered orthorhombic monatomic form.
Being less reactive than chlorine but more reactive than iodine, bromine reacts vigorously with metals, especially in the presence of water, to give bromide salts. It reacts with most organic compounds, especially upon illumination, which causes the dissociation of the diatomic molecule into bromine radicals:
- Br2 ⇌ 2 Br·
Bromine has two stable isotopes, 79Br (50.69%) and 81Br (49.31%). At least 23 radioisotopes are known. Many of the bromine isotopes are fission products. Several of the heavier bromine isotopes from fission are delayed neutron emitters, important to the controllability of a nuclear reactor. All of the radioactive bromine isotopes are relatively short-lived. The longest half-life is the neutron deficient 77Br at 2.376 days. The longest half-life on the neutron rich side is 82Br at 1.471 days. A number of bromine isotopes exhibit metastable isomers. Stable 79Br exhibits a radioactive isomer, with a half-life of 4.86 seconds. It decays by isomeric transition to the stable ground state.
The isotopes of bromine range from 67Br to 98Br. One of these, 67Br has an unknown half life. Six isotopes, 95Br to 98Br, 68Br, and 69Br have half-lives under a microsecond. The isotopes 91Br to 94Br and 70Br have half lives of a microsecond to a second. All but two of the remaining isotopes of bromine have half lives of 1 second to 16.2(2) hours. The other two, 79Br and 81Br, are stable.
The three lightest isotopes of bromine (67Br to 69Br) decay by proton emission. The isotopes 70Br through 78Br decay by electron capture or positron emission. 80Br and 82Br to 97Br decay via electron emission. 98Br decays via neutron emission.
Balard found bromine chemicals in the ash of seaweed from the salt marshes of Montpellier. The seaweed was used to produce iodine, but also contained bromine. Balard distilled the bromine from a solution of seaweed ash saturated with chlorine. The properties of the resulting substance resembled that of an intermediate of chlorine and iodine; with those results he tried to prove that the substance was iodine monochloride (ICl), but after failing to do so he was sure that he had found a new element and named it muride, derived from the Latin word muria for brine.
Löwig isolated bromine from a mineral water spring from his hometown Bad Kreuznach in 1825. Löwig used a solution of the mineral salt saturated with chlorine and extracted the bromine with diethyl ether. After evaporation of the ether a brown liquid remained. With this liquid as a sample for his work he applied for a position in the laboratory of Leopold Gmelin in Heidelberg. The publication of the results was delayed and Balard published his results first.
After the French chemists Louis Nicolas Vauquelin, Louis Jacques Thénard, and Joseph-Louis Gay-Lussac approved the experiments of the young pharmacist Balard, the results were presented at a lecture of the Académie des Sciences and published in Annales de Chimie et Physique. In his publication, Balard states that he changed the name from muride to brôme on the proposal of M. Anglada. Brôme (bromine) derives from the Greek βρωμος (stench). Other sources claim that the French chemist and physicist Joseph-Louis Gay-Lussac suggested the name brôme for the characteristic smell of the vapors. Bromine was not produced in large quantities until 1860.
Apart from some minor medical applications, the first commercial use was the daguerreotype. In 1840, bromine was discovered to have some advantages over the previously used iodine vapor to create the light sensitive silver halide layer in daguerreotypy.
Potassium bromide and sodium bromide were used as anticonvulsants and sedatives in the late 19th and early 20th centuries, until they were gradually superseded by chloral hydrate and then the barbiturates. In the early years of the First World War, bromine compounds such as xylyl bromide were used as poison gas.
The diatomic element Br2 does not occur naturally. Instead, bromine exists exclusively as bromide salts in diffuse amounts in crustal rock. From leaching over long periods of time, bromide salts have accumulated in sea water at 65 parts per million (ppm), which is less than chloride. Bromine may be economically recovered from bromide-rich brine wells and from the Dead Sea waters (up to 50,000 ppm). It exists in the Earth's crust at an average concentration of 0.4 ppm, making it the 62nd most abundant element. The bromine concentration in soils varies normally between 5 and 40 ppm, but some volcanic soils can contain up to 500 ppm. The concentration of bromine in the atmosphere is extremely low, at only a few ppt. A large number of organobromine compounds are found in small amounts in nature.
China's bromine reserves are located in the Shandong Province and Israel's bromine reserves are contained in the waters of the Dead Sea. The largest bromine reserve in the United States is located in Columbia County and Union County, Arkansas, U.S.
Bromine production has increased sixfold since the 1960s. Approximately 556,000 tonnes (worth around US $2.5 billion) were produced in 2007 worldwide, with the predominant contribution from the United States (226,000 t) and Israel (210,000 t). US production was excluded from the United States Geological Survey after 2007, and from the 380,000 tonnes mined by other countries in 2010, 140,000 t were produced by China, 130,000 t by Israel and 80,000 t by Jordan.
- 2 Br− + Cl2 → 2 Cl− + Br2
Laboratory methods of production
Bromine is not usually prepared in the laboratory because it is readily available commercially and has a long shelf-life. Small batches of bromine can be generated through the reaction of solid sodium bromide with concentrated sulfuric acid (H2SO4). The first stage is formation of hydrogen bromide (HBr), a gas, and some of the HBr is further oxidized by the sulfuric acid to form bromine (Br2) and sulfur dioxide (SO2).
- NaBr (s) + H2SO4 (aq) → HBr (aq) + NaHSO4 (aq)
- 2 HBr (aq) + H2SO4 (aq) → Br2 (g) + SO2 (g) + 2 H2O (l)
Non oxidizing acid alternatives, such as reacting dilute hydrobromic acid with sodium hypobromite, are also workable because the hypobromous acid product is unstable in the presence of bromide and is reduced:
- 2 OBr− (aq) + 4 HBr (aq) → 2Br2 + 2H2O + 2Br−
The reactions are the reverse of disproportionation reactions of elemental bromine in base, and are called comproportionation. A similar reaction happens between sodium hypochlorite and bromide ions, leading to elemental bromine. This is readily demonstrated by mixing potassium bromide with simple household bleach.
Reactions involving bromide ions in the presence of an acid and an oxidizing agent, such as potassium permanganate or manganese dioxide, also produce bromine, analogous to the production of elemental chlorine and iodine from an acid and oxidant.
Like iodine, bromine is soluble in chloroform but only slightly soluble in water. In water, the solubility can be increased by the presence of bromide ions. Concentrated solutions of bromine are rarely prepared in the lab because of hazards. As with chlorine or iodine solutions, sodium thiosulphate (or any soluble thiosulphate) is an effective reagent for reducing bromine to colorless odorless bromide. Sodium thiosulfate ("fixer's hypo") is used in photographic processing labs to neutralize free bromine in silver bromide film emulsions.
Compounds and chemistry
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As with other halogens, bromine can substitute for hydrogen in hydrocarbons, bonding covalently to carbon. The C-Br product is generally colorless if the corresponding C-H compound is colorless. This reaction tends to increase the density and raise the melting and boiling points of organic compounds.
Organic compounds are brominated by either addition or substitution reactions. Bromine undergoes electrophilic addition to the double-bonds of alkenes, via a cyclic bromonium intermediate. In non-aqueous solvents such as carbon disulfide, this yields the di-bromo product. For example, reaction with ethylene will produce 1,2-dibromoethane. Bromine also undergoes electrophilic substitution to phenols and anilines. When used as bromine water, a small amount of the corresponding bromohydrin is formed as well as the dibromo compound. So reliable is the reactivity of bromine that bromine water is employed as a reagent to test for the presence of alkenes, phenols, and anilines. Like the other halogens, bromine participates in free radical reactions. For example, hydrocarbons are brominated upon treatment with bromine in the presence of light.
Bromine, sometimes with phosphorus as a catalyst, easily brominates carboxylic acids at the α-position. This method, the Hell-Volhard-Zelinsky reaction, is the basis of the commercial route to bromoacetic acid. N-Bromosuccinimide is commonly used as a substitute for elemental bromine, being easier to handle, and reacting more mildly and thus more selectively. Organic bromides are often preferable relative to the less reactive chlorides and more expensive iodide-containing reagents. Thus, Grignard and organolithium compound are most often generated from the corresponding bromides.
Certain bromine-related compounds have been evaluated to have an ozone depletion potential or bioaccumulate in living organisms. As a result, many industrial bromine compounds are no longer manufactured, are being restricted, or scheduled for phasing out. The Montreal Protocol mentions several organobromine compounds for this phase out.
Inorganic bromine compounds adopt a variety of oxidation states from −1 to +7. In nature, bromide (Br−) is by far the most common state, and departures from this -1 state are always caused by living organisms and bromide's interaction with biologically produced oxidants, such as free oxygen.
As with other halogens, the bromide ion is colorless and forms a number of transparent ionic mineral salts, analogous to chloride. It is highly soluble in water.
Examples of compounds for bromine's various oxidation states are shown below:
- Br2 + 2 I− → 2 Br− + I2
Bromine will also oxidize metals and metalloids to the corresponding bromides. Anhydrous bromine is less reactive toward many metals than hydrated bromine, however. Dry bromine reacts vigorously with aluminium, titanium, mercury as well as alkaline earths and alkali metals.
Dissolving bromine in alkaline solution gives a mixture of bromide and hypobromite:
- Br2 + 2 OH− → Br− + OBr− + H2O
This hypobromite is responsible for the bleaching abilities of bromide solutions. Warming of these solutions causes the disproportion reaction of the hypobromite to give bromate, a strong oxidising agent very similar to chlorate.
- 3 BrO−
3 + 2 Br−
- BrO3− + H2O + F2 → BrO−
4 + 2 HF
- BrO3− + O3 → BrO−
4 + O2
Bromine reacts violently and explosively with aluminium metal, forming aluminium bromide:
- 2 Al + 3 Br2 → 2 AlBr3
Bromine reacts with hydrogen in gaseous form and gives hydrogen bromide:
- C2H4 + Br2 → CH2BrCH2Br
Brominated flame retardants represent a commodity of growing importance, and represent the largest commercial use of bromine. When the brominated material burns, the flame retardant produces hydrobromic acid which interferes in the radical chain reaction of the oxidation reaction of the fire. The mechanism is that the highly reactive hydrogen radicals, oxygen radicals, and hydroxy radicals react with hydrobromic acid to form less reactive bromine radicals (i.e., free bromine atoms). Bromine atoms may also react directly with other radicals to help terminate the free radical chain-reactions that characterize combustion.
To make brominated polymers and plastics, bromine-containing compounds can be incorporated into the polymer during polymerization. One method is to include a relatively small amount of brominated monomer during the polymerization process. For example, vinyl bromide can be used in the production of polyethylene, polyvinylchloride or polypropylene. Specific highly brominated molecules can also be added that participate in the polymerization process For example, tetrabromobisphenol A can be added to polyesters or epoxy resins, where it becomes part of the polymer. Epoxys used in printed circuit boards are normally made from such flame retardant resins, indicated by the FR in the abbreviation of the products (FR-4 and FR-2). In some cases the bromine containing compound may be added after polymerization. For example, decabromodiphenyl ether can be added to the final polymers.
A number of gaseous or highly volatile brominated halomethane compounds are non-toxic and make superior fire suppressant agents by this same mechanism, and are particular effective in enclosed spaces such as submarines, airplanes, and spacecraft. However, they are expensive and their production and use has been greatly curtailed due to their effect as ozone-depleting agents. They are no longer used in routine fire extinguishers, but retain niche uses in aerospace and military automatic fire-suppression applications. They include bromochloromethane (Halon 1011, CH2BrCl), bromochlorodifluoromethane (Halon 1211, CBrClF2), and bromotrifluoromethane (Halon 1301, CBrF3).
Ethylene bromide was an additive in gasolines containing lead anti-engine knocking agents. It scavenges lead by forming volatile lead bromide, which is exhausted from the engine. This application accounted for 77% of the bromine use in 1966 in the US. This application has declined since the 1970s due to environmental regulations (see below).
Poisonous bromomethane was widely used as pesticide to fumigate soil and to fumigate housing, by the tenting method. Ethylene bromide was similarly used. These volatile organobromine compounds are all now regulated as ozone depletion agents. The Montreal Protocol on Substances that Deplete the Ozone Layer scheduled the phase out for the ozone depleting chemical by 2005, and organobromide pesticides are no longer used (in housing fumagation they have been replaced by such compounds as sulfuryl fluoride, which contain neither the chlorine or bromine organics which harm ozone). Prior to the Montreal protocol in 1991 (for example) an estimated 35,000 tonnes of the chemical were used to control nematodes, fungi, weeds and other soil-borne diseases.
Medical and veterinary use
Bromide compounds, especially potassium bromide, were frequently used as general sedatives in the 19th and early 20th century. Bromides in the form of simple salts are still used as anticonvulsants in both veterinary and human medicine, although the latter use varies from country to country. For example, the U.S. Food and Drug Administration (FDA) does not approve bromide for the treatment of any disease, and it was removed from over-the-counter sedative products like Bromo-Seltzer, in 1975. Thus, bromide levels are not routinely measured by medical laboratories in the U.S. However, U.S. veterinary medical diagnostic testing laboratories will measure blood bromide levels on request, as an aid to treatment of epilepsy in dogs.
Toxicity. Long-term use of potassium bromide (or any bromide salt) can lead to bromism. This state of central nervous system depression causes the moderate toxicity of bromide in multi-gram doses for humans and other mammals. The very long half-life of bromide ion in the body (~12 days) also contributes to toxicity from bromide build-up in body fluids. Bromide ingestion may also cause a skin eruption resembling acne.
- The bromides of calcium, sodium, and zinc account for a sizable part of the bromine market. These salts form dense solutions in water that are used as drilling fluids sometimes called clear brine fluids.
- Bromine is also used in the production of brominated vegetable oil, which is used as an emulsifier in many citrus-flavored soft drinks (for example, Mountain Dew). After the introduction in the 1940s the compound was extensively used until the UK and the US limited its use in the mid 1970s and alternative emulsifiers were developed.
Soft drinks containing brominated vegetable oil are still sold in the US (2013).
- Several dyes, agrichemicals, and pharmaceuticals are organobromine compounds. 1-Bromo-3-chloropropane, 1-bromoethylbenzene, and 1-bromoalkanes are prepared by the antimarkovnikov addition of HBr to alkenes. Ethidium bromide, EtBr, is used as a DNA stain in gel electrophoresis.
- High refractive index compounds
- Bromine, like chlorine, is used in maintenance of swimming pools, especially spas (hot tubs), where it is generated in situ from a bromide plus hydrogen peroxide. In spas, the high water temperatures render chlorinated water purification and buffering compounds unstable, and bromine compounds may improve the life of the free-halogen antimicrobial.
- Water purification compounds, disinfectants and insecticides, such as tralomethrin (C22H19Br4NO3).
- Potassium bromide is used in some photographic developers to inhibit the formation of fog (undesired reduction of silver).
- Scandium bromide is used in solid state synthesis of unusual clusters which are of interest for their structure and magnetic properties.
- Bromine vapor is used as the second step in sensitizing daguerreotype plates to be developed under mercury vapor. Bromine acts as an accelerator to the light sensitivity of the previously iodized plate.
- Bromine is also used to reduce mercury pollution from coal-fired power plants. This can be achieved either by treating activated carbon with bromine or by injecting bromine compounds onto the coal prior to combustion.
- Bromine can also be artificially substituted for the methyl substituent in the nitrogenous base thymine of DNA, creating the base analog 5-bromouracil. When this base is incorporated into DNA its different hydrogen bonding properties may cause mutation at the site of that base pair. The compound 5-bromouracil is thus an artificial mutagen.
- Aqueous bromine can be used to test for the presence of alkenes. The aqueous bromine is shaken with the unknown substance and will decolorize if alkenes are present.
Bromine (in the form of bromide ions) is one of more than ten elements considered to be possibly essential in humans. According to a 2014 study at Vanderbilt University involving experiments with the fruit fly Drosophila melanogaster, bromide ions are essential to the proper functioning of the protein peroxidasin. The same researchers had previously identified peroxidasin as critical to the extracellular framework of all (multicellular) animals.
Inorganic bromine and organobromine compounds perform other biological functions, which may be essential, or at least optimal and preferred. For example, in the presence of hydrogen peroxide, H2O2, formed by the eosinophil, and either chloride or bromide ions, eosinophil peroxidase provides a potent mechanism by which eosinophils kill multicellular parasites (such as, for example, the nematode worms involved in filariasis) and some bacteria (such as tuberculosis bacteria). Eosinophil peroxidase is a haloperoxidase that preferentially uses bromide over chloride for this purpose, generating hypobromite (hypobromous acid).
A brominated ester (2-octyl γ-bromoacetoacetate) is produced endogenously by mammalian (including human) tissue and has been shown to prolong REM sleep in cats.
Marine organisms are the main source of organobromine compounds. More than 1600 of such compounds were identified by 1999. The most abundant is methyl bromide (CH3Br), of which an estimated 56,000 tonnes is produced by marine algae each year. The essential oil of the Hawaiian alga Asparagopsis taxiformis consists of 80% tribromomethane (bromoform). Most of such organobromine compounds in the sea are made by the action of a unique algal enzyme, vanadium bromoperoxidase. Though that enzyme is the most prolific creator of organic bromides, other bromoperoxidases exist in nature that do not use vanadium.
The fabric dye Tyrian purple is a bromine-containing organic compound used by humans since ancient times. The brominated indole indigo dye is produced by a medium-sized predatory sea snail, the marine gastropod Murex brandaris. The organobromine nature of the compound was not discovered until 1909 (see Paul Friedländer).
Elemental bromine is toxic and causes chemical burns on human flesh. As an oxidizing agent, it is incompatible with most organic and inorganic compounds. Caution is required when transporting bromine; it is commonly carried in steel tanks lined with lead, supported by strong metal frames.
When certain bromide compounds containing bromine are mixed with potassium permanganate (KMnO4) and an acidic substance, they will form a pale brown cloud of bromine gas.
- 6 Br− + 2 MnO−
4 + 8 H+ → 3 Br2 + 2 MnO2 + 4 H2O
The gas smells like bleach and is very irritating to the mucous membranes. Upon exposure, one should move to fresh air immediately. With any symptoms of bromine poisoning, medical attention is needed.
The Occupational Safety and Health Administration (OSHA) has set a permissible exposure limit (PEL) for bromine at a time-weighted average (TWA) of 0.1 ppm. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) of TWA 0.1 ppm and a short-term limit of 0.3 ppm. The exposure to bromine immediately dangerous to life and health (IDLH) is 3 ppm. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.
|750 ppm||mouse||9 min|
|240 ppm||mouse||2 hr|
|LCLo: 180 ppm||rabbit||6.5 hr|
|5500 mg/kg||guinea pig||oral|
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