Bromoperoxidases are enzymes that catalyse the bromination of hydrocarbons. The enzymes accomplish this reaction via the following reaction:
- RH + Br− + 1/2 H2O2 → RBr + H2O
Related chloroperoxidase enzymes effect chlorination.
In the nomenclature of haloperoxidase, bromoperoxidases classically are unable to oxidize chloride at all. For example, eosinophil peroxidase appears to prefer bromide over chloride, yet is not considered a bromoperoxidase because it is able to use chloride.
The bromoperoxidases found in marine algae feature vanadium at the active site (see vanadium bromoperoxidase). Otherwise vanadium is unusual cofactor in biology. By virtue of this family of enzymes, a variety of brominated natural products have been isolated from marine sources.
- Butler, A., "Vanadium haloperoxidases", Current Opinion in Chemical Biology, 1998, 2, 279-285.