Brucella abortus

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The genus Brucella includes the species of microorganisms responsible for an important zoonosis named brucellosis. One of the most relevant species is Brucella abortus, which infects bovines, preferentially.

In order to understand the mechanisms of pathogenicity, a lot of research has been performed by the study of reference strains, for example B. abortus strain 2308 and B. abortus 9-941.

Even though these bacteria have been studied for long, the improvements in molecular biology techniques keep introducing new knowledge that helps the understanding of the host-pathogen interaction in this infection. The introduction of whole genome sequencing amplified the acquirement of new information which has been continuously complemented and confirmed with experimental information, that supports the analysis obtained through bioinformatics.

Genome annotation: Brucella abortus 2308W[edit]

All coding sequences (CDs) information of the genome of Brucella abortus strain 2308 Wisconsin is available in an editable way. As new information is constantly generated, the availability of updated CDs products, gene length and other features, enhances the advance in research related to this genus.

-- This page is in progress, genes will be added progressively, for the information to be verified --

Chromosome 1[edit]

Genes 1 to 1071

Locus_tag Gene_synonym Locus_tag in 2308 Product Notes References
BAW_10001 dnaA BAB1_0001 chromosomal replication initiationprotein binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation ofchromosomal replication; can also affect transcription of multiple genes including itself. Chain et al. 2005. Infect Immun. 73:8353-61;[1]Brucella abortus 2308; accesion number NC_007618
BAW_10002 dnaN BAB1_0002 DNA polymerase III subunit beta binds the polymerase to DNA and acts as a sliding clamp Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10003 recF BAB1_0003 recombination protein F Required for DNA replication; binds preferentially to single-stranded; linear DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10004 moeB BAB1_0004 molybdopterin biosynthesis proteinMoeB ATP-dependent adenylate transferase; transfers adenyl moiety to the MoeD subunit of molybdopterin synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10005 BAW_10005 BAB1_0005 pyridine nucleotide-disulfide oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10006 BAW_10006 BAB1_0006 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10007 BAW_10007 BAB1_0007 ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10008 BAW_10008 BAB1_0008 ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10009 BAW_10009 BAB1_0009 solute-binding family 5 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10010 BAW_10010 BAB1_0010 solute-binding family 5 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10011 BAW_10011 BAB1_0011 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10012 BAW_10012 BAB1_0012 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10013 BAW_10013 BAB1_0013 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10014 BAW_10014 BAB1_0014 Pseudogene. Frame shift; similar to BMEI1930. Leu/Ile/Val-binding protein family:Extracellular ligand-binding receptor DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8;Brucella melitensis 16M accession number NC_003317
BAW_10015 BAW_10015 BAB1_0015 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10016 BAW_10016 BAB1_0016 enoyl-CoA hydratase Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10017 BAW_10017 BAB1_0017 hydroxymethylglutaryl-CoA lyase catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10018 BAW_10018 BAB1_0018 methylcrotonoyl-CoA carboxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10019 BAW_10019 BAB1_0019 carboxyl transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10020 ivd BAB1_0020 Pseudogene. Deletion at 5’ end as compared to BS1330_I0020; predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53[2]
BAW_10021 BAW_10021 BAB1_0021 Pseudogene. Truncation at 3’ end; similar to 4'-mycarosyl isovaleryl-CoA transferase [Brucella abortus str. 2308 A] and to BS1330_I0023 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 2308A accession number GCA_000182625.1
BAW_10022 BAW_10022 BAB1_0022 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10023 aroA BAB1_0023 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvateand3-phosphoshikimate in tryptophan biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10024 cmk BAB1_0024 cytidylate kinase Catalyzes the formation of (d)CDP from ATP and (d)CMP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10025 rpsA BAB1_0025 30S ribosomal protein S1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs andisitselfbound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10026 BAW_10026 BAB1_0026 membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10027 lysR13 BAB1_0027 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86[3]
BAW_10028 BAW_10028 BAB1_0028 lytic murein transglycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10029 recR BAB1_0029 recombination protein RecR involved in a recombinational process of DNA repair; independent of the recBC complex Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10030 BAW_10030 BAB1_0030 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10031 BAW_10031 BAB1_0031 DNA polymerase III subunits gammaand tau catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chainserves asa scaffold to help in the dimerizaton of the alpha;epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10032 ffs ffs ffs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10033 BAW_10033 BAB1_0032 histidine triad protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10034 BAW_10034 BAB1_0033 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10035 pheA BAB1_0034 prephenate dehydratase catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10036 kdsB BAB1_0035 3-deoxy-manno-octulosonate cytidylyltransferase CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10037 BAW_10037 BAB1_0036 cysteine desulfurase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10038 BAW_10038 BAB1_0037 molybdopterin biosynthesis enzyme Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10039 BAW_10039 BAB1_0038 cytochrome o ubiquinol oxidase subunit II Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10040 qoxB BAB1_0039-0040 Pseudogene. Frame shift; similar to BS1330_I0043 (Brucella suis 1330). Cytochrome c oxidase, subunit I Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10041 BAW_10041 BAB1_0041 cytochrome c oxidase subunit III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10042 qoxD BAB1_0042 cytochrome C oxidase subunit IV Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10043 BAW_10043 BAB1_0043 histidine kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10044 BAW_10044 BAB1_0044 peptide-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10045 tamA BAB1_0045 surface antigen Bacterial surface antigen (D15) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10046 tamB BAB1_0046 Autotransporter translocation and assembly factor TamB This protein translocates adhesins and is essential for full virulence and intracelullar trafficking Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10047 BAW_10047 BAB1_0047 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10048 BAW_10048 BAB1_0048 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10049 BAW_10049 BAB1_0049 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10050 BAW_10050 BAB1_0050 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10051 BAW_10051 BAB1_0051 Copper binding protein This protein binds copper and is related to inorganic ion transport and metabolism Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10052 BAW_10052 BAB1_0052 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10053 BAW_10053 BAB1_0053 lactoylglutathione lyase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10054 BAW_10054 BAB1_0054 sodium:proton antiporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10055 pgm BAB1_0055 phosphoglucomutase catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10056 BAW_10056 BAB1_0056 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10057 BAW_10057 BAB1_0057 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10058 BAW_10058 BAB1_0058 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10059 frcK BAB1_0059 nucleoside triphosphate hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10060 BAW_10060 BAB1_0060 fumarylacetoacetate (FAA) hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10061 BAW_10061 BAB1_0061 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10062 BAW_10062 BAB1_0062 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10063 BAW_10063 BAB1_0063 Protein with unknown function Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10064 BAW_10064 BAB1_0064 SLT domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10065 BAW_10065 BAB1_0065 Hly-III-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10066 dnaE2 BAB1_0066 error-prone DNA polymerase DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10067 BAW_10067 BAB1_0067 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10068 BAW_10068 BAB1_0068 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10069 btaE BAB1_0069 btaE; hyaluronate-binding autotransporter adhesin An adhesin that belongs to the trimeric autotransporter family; is required for full virulence and defines a specific adhesive pole of Brucella suis. Infect Immun 81:996-1007 (2013). This autotransporter is one of the four predicted in Brucella genomes and it has been suggested that the combination present in each genome is related to host and tissue tropism. Other autotransporters with different degree of similarity are encoded in BOV_A0152; BOV_A1053; and BOV_1937 (pseudogene in B ovis; marine isolates and B abortus). All are pseudogenes in B melitensis 16M Ruiz-Ranwez et al. 2013. Infect Immun. 81(3):996-1007[4]
BAW_10070 BAW_10070 BAB1_0070 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10071 argG BAB1_0071 argininosuccinate synthase catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis; AMP-forming Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10072 BAW_10072 BAB1_0072 lysine exporter protein LysE/YggA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10073 BAW_10073 BAB1_0073 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10074 BAW_10074 BAB1_0074 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10075 BAW_10075 BAB1_0075 predicted protein Putative uncharacterized protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10076 BAW_10076 BAB1_0076 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10077 phhB BAB1_0077 pterin-4-alpha-carbinolamine dehydratase 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1;2-dihydroxypropyl)-7; 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1;2-dihydroxypropyl)-5;6;7; 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10078 BAW_10078 BAB1_0078-0079 Pseudogene. Frame shift; similar to BS1330_I0083 (Brucella suis 1330). Low molecular weight phosphotyrosine protein phosphatase. Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10079 BAW_10079 BAB1_0080 2`-5` RNA ligase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10080 BAW_10080 BAB1_0081 GDSL family lipase Lipolytic enzyme; G-D-S-L family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10081 BAW_10081 BAB1_0082 sugar ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10082 BAW_10082 BAB1_0083 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10083 yccA BAB1_0084 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10084 pat BAB1_0085-0086 Pseudogene. Frame shift; phosphinothricin N-acetyltransferase; similar to BS1330_I0089 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10085 BAW_10085 BAB1_0087 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10086 BAW_10086 BAB1_0088 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10087 BAW_10087 BAB1_0089 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10088 acnA BAB1_0090 aconitate hydratase Catalyzes the conversion of citrate to isocitrate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10089 ccmA BAB1_0091 cytochrome c biogenesis protein CcmA ATP-binding protein; required for proper cytochrome c maturation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10090 ccmB BAB1_0092 cytochrome c-type biogenesis protein CcmB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10091 ccmC BAB1_0093 cytochrome c-type biogenesis protein CcmC Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10092 BAW_10092 BAB1_0094 heme exporter protein CcmD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10093 CycY BAB1_0095 thiol:disulfide oxidoreductase DsbE Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10094 ilvD BAB1_0096 dihydroxy-acid dehydratase catalyzes the dehydration of 2;3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate invaline andisoleucine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10095 BAW_10095 BAB1_0097 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10096 BAW_10096 BAB1_0098 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10097 BAW_10097 BAB1_0099 response regulator receiver Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10098 BAW_10098 BAB1_0100 AsnC family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10099 BAW_10099 BAB1_0101 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10100 BAW_10100 BAB1_0102 Lipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10101 BAW_10101 BAB1_0103 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10102 BAW_10102 BAB1_0104 sulfate ABC transporter permease subunit CysW Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10103 BAW_10103 BAB1_0105 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10104 cysW-1 BAB1_0106 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10105 BAW_10105 BAB1_0107 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10106 cgs BAB1_0108 cyclic beta 1-2 glucan synthetase Ciocchini et al. 2006. Glycobiology.16(7):679-91[5]
BAW_10107 pncB BAB1_0109 nicotinate phosphoribosyltransferase catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinateD-ribonucleotide and diphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10108 BAW_10108 BAB1_0110 phenazine biosynthesis PhzC/PhzF protein Phenazine biosynthesis PhzC/PhzF protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10109 BAW_10109 BAB1_0111 methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10110 cscK BAB1_0112 ribokinase:carbohydrate kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10111 BAW_10111 BAB1_0113 short-chain dehydrogenase/reductase SDR:glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10112 pbp1-like BAB1_0114 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10113 BAW_10113 BAB1_0115 outer membrane protein Omp25d precursor similar to BMEI 1830; outer membrane protein Omp25d precursor. This protein is expressed in B. melitensis 16M and B. suis 1330. Member of the group 3 of outer membrane proteins. Contains a common site of signal peptide cleavage (AXAAD). Its function is unknown. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618; Sahli et al. 2003. Infect Immun. 71:4326-32[6]
BAW_10114 BAW_10114 BAB1_0116 outer membrane protein Omp25c precursor similar to BMEI 1829; outer membrane protein Omp25c precursor. This protein is expressed in B. suis 1330. Member of the group 3 of outer membrane proteins. Contains a common site of signal peptide cleavage (AXAAD). Its function is unknown. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Sahli et al. 2003. Infect Immun. 71:4326-32; Wagner et al. 2002. Proteomics. 2: 1047-60[7]
BAW_10115 BAW_10115 BAB1_0117 3'-5' exonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10116 BAW_10116 BAB1_0118 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10117 BAW_10117 BAB1_0119 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10118 polA BAB1_0120 DNA polymerase I has 3'-5' exonuclease; 5'-3' exonuclease and 5'-3'polymerase activities; primarily functions tofillgaps during DNA replication and repair Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10119 BAW_10119 BAB1_0121 ATP-dependent helicase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10120 gyrB BAB1_0122 DNA gyrase subunit B negatively supercoils closed circular double-stranded DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10121 BAW_10121 BAB1_0123 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10122 BAW_10122 BAB1_0124 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10123 BAW_10123 BAB1_0125-0126-0127 Pseudogene. Frame shift; similar to BS1330_I0128 (Brucella suis 1330); predicted membrane protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10124 BAW_10124 BAB1_0127 GNAT family N-acetyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10125 BAW_10125 BAB1_0128 zinc-containing alcohol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10126 BAW_10126 BAB1_0129 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10127 BAW_10127 BAB1_0130-0131 Pseudogene. Frame shift. DEAD/DEAH box helicase:Helicase; C-terminal:ATP/GTP-binding site motif A (P-loop):Helicase-associated region Blast match with several ATP-dependent helicase ;
BAW_10128 prrB BAB1_0132 ATPase-like ATP-binding protein Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10129 BAW_10129 BAB1_0135 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10130 prrA BAB1_0136 response regulator receiver Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10131 BAW_10131 BAB1_0137 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10132 BAW_10132 BAB1_0138 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10133 BAW_10133 BAB1_0139 nitrogen-fixing NifU; C-terminal Nitrogen-fixing NifU; C-terminal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10134 BAW_10134 BAB1_0140 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10135 trpS BAB1_0141 tryptophanyl-tRNA synthetase catalyzes a two-step reaction; first charging a tryptophan molecule by linking its carboxylgroup to the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10136 murJ BAB1_0142 virulence factor MVIN-like Sham et al. 2014. Science. 11;345(6193):220-2[8]
BAW_10137 glnD BAB1_0143 PII uridylyl-transferase catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10138 BAW_10138 BAB1_0144/BMEI1803 Phosphate acetyl/butaryl transferase No differences found as compared to Brucella melitensis 16M to consider it a pseudogene; corresponds to BMEI1803; NADP-dependent malic enzyme Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8[9]
BAW_10139 BAW_10139 BAB1_0144/BMEI1802 Phosphate acetyl/butaryl transferase No differences found as compared to Brucella melitensis 16M to consider it a pseudogene; corresponds to BMEI1802; NADP-dependent malic enzyme Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10140 mutS BAB1_0146 DNA mismatch repair protein MutS This protein performs the mismatch recognition step during the DNA repair process Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10141 BAW_10141 BAB1_0147 Ornithine N-acetylase Catalizes the first step in the synthesis of Ornithine Lipid Palacios-Chaves et al. 2011. PLoS One. 6(1):e16030[10]
BAW_10142 lspA BAB1_0148 lipoprotein signal peptidase lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10143 BAW_10143 BAB1_0149 tRNA/rRNA methyltransferase SpoU Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10144 BAW_10144 BAB1_0150 SAM dependent methyltransferase SAM dependent methyltransferase; putative Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10145 BAW_10145 BAB1_0151 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10146 ihfB BAB1_0152 integration host factor subunit beta This protein is one of the two subunits of integration host factor; a specific DNA-bindingproteinthat functions in genetic recombination as well as in transcriptional and translational control Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10147 sppA BAB1_0153 Clp protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10148 lptC BAB1_0154 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10149 lptA BAB1_0155 OstA-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10150 lptB BAB1_0156 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10151 rpoN BAB1_0157 RNA polymerase factor sigma-54 sigma factors are initiation factors that promote the attachment of RNA polymerase to specificinitiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions; rpoN1 gene was regulated in response to oxygen. Not need it for B. melitensis 16M to cause damage in cells or mice Delory et al. 2006. J Bacteriol. 188(21):7707-10;
BAW_10152 BAW_10152 BAB1_0158 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10153 yfiA BAB1_0159 sigma 54 modulation protein/ribosomal protein S30EA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10154 ptsN BAB1_0160 PTS transporter subunit IIA-like nitrogen-regulatory protein PtsN Phosphoenolpyruvate-dependent sugar phosphotransferase system; EIIA 2:PTS IIA-like nitrogen-regulatory protein PtsN Dozot et al. 2010. PLoS One. 5(9). pii: e12679[11]
BAW_10155 BAW_10155 BAB1_0161 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10156 BAW_10156 BAB1_0162 heat shock protein Hsp20 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10157 BAW_10157 BAB1_0163 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10158 BAW_10158 BAB1_0164 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10159 BAW_10159 BAB1_0165 helix-hairpin-helix DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10160 BAW_10160 BAB1_0166 CysZ-like protein putative role in sulfur assimilation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10161 BAW_10161 BAB1_0167 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10162 BAW_10162 BAB1_0168 ribokinase:carbohydrate kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10163 BAW_10163 BAB1_0169 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10164 grpE BAB1_0170 heat shock protein GrpE with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation ofstress-denatured proteins; may act as a thermosensor Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10165 hrcA BAB1_0171 heat-inducible transcription repressor Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10166 rph BAB1_0172 ribonuclease PH RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5'exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10167 BAW_10167 BAB1_0173-0174 Pseudogene. Frame shift; similar to BS1330_I0174 (Brucella suis 1330); lactoylglutathione lyase, putative Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10168 BAW_10168 BAB1_0175 putative deoxyribonucleotide triphosphate pyrophosphatase HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions toremove misincorporated bases such as xanthine or hypoxanthine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10169 BAW_10169 BAB1_0176 coproporphyrinogen III oxidase catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10170 BAW_10170 BAB1_0177 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10171 BAW_10171 BAB1_0178 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10172 cysG BAB1_0179 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10173 BAW_10173 BAB1_0180 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10174 cysI BAB1_0181 nitrite/sulfite reductase ferredoxin subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10175 cysH BAB1_0182 phosphoadenosine phosphosulfate reductase catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10176 BAW_10176 BAB1_0183 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10177 BAW_10177 BAB1_0184 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10178 BAW_10178 BAB1_0185 methylated-DNA-[protein]-cysteineS-methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10179 BAW_10179 BAB1_0186 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10180 BAW_10180 BAB1_0187 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10181 metH BAB1_0188 B12-dependent methionine synthase one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reactionfrommethyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10182 babR BAB1_0190 LuxR family transcriptional regulator Also known as BlxR Taminiau et al. 2002. Infect Immun. 70(6):3004-11;[12]Rambow-Larsen et al. 2008. J Bacteriol. 190(9): 3274_3282[13]
BAW_10183 BAW_10183 BAB1_0191 aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10184 BAW_10184 BAB1_0192 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10185 cysD BAB1_0193 sulfate adenylyltransferase subunit 2 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10186 CysNC BAB1_0194 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors thatareactiveon the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10187 cysQ BAB1_0195 inositol phosphatase/fructose-1;6-bisphosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10188 crp2 BAB1_0196 Crp/Fnr family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10189 BAW_10189 BAB1_0197 LuxR family regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10190 BAW_10190 BAB1_0198 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10191 glpR BAB1_0199 glycerol-3-phosphate transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10192 glpD BAB1_0200 glycerol-3-phosphate dehydrogenase in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10193 BAW_10193 BAB1_0201 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10194 BAW_10194 BAB1_0202-0203 Pseudogene. Frame shift; similar to BS1330_I0202 (Brucella suis 1330). Aldehyde dehydrogenase Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10195 BAW_10195 BAB1_0204 zinc-containing alcohol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10196 BAW_10196 BAB1_0205 Pseudogene. 33 bp insertion at 3' end; predicted protein; similar to BS1330_I0204 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10197 BAW_10197 BAB1_0206 transcriptional regulator LacI Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10198 BAW_10198 BAB1_0207 Pseudogene. Similar to BMEI1742 (Brucella melitensis 16M). Double frame shift; ABC transporter ATP-binding protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10199 BAW_10199 BAB1_0210 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10200 BAW_10200 BAB1_0211 aldehyde dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10201 BAW_10201 BAB1_0212 ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10202 BAW_10202 BAB1_0213 TENA/THI-4 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10203 BAW_10203 BAB1_0214 ABC transporter substrate-bindingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10204 thiE BAB1_0215 thiamine-phosphate pyrophosphorylase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethylpyrimidine pyrophosphate to form thiamine monophosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10205 thiG BAB1_0216 thiazole synthase functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzestheformation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10206 thiS BAB1_0217 sulfur carrier protein ThiS Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10207 thiO BAB1_0218 mercuric reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10208 thiD BAB1_0219 aspartic protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10209 BAW_10209 BAB1_0220 PAS domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10210 BAW_10210 BAB1_0221 copper-translocating P-type ATPase similar to BR0220; copper-translocating P-type ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10211 merR7 BAB1_0222 transcriptional regulator MerR Bacterial regulatory protein; MerR family:ATP/GTP-binding site motif A (P-loop) Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10212 BAW_10212 BAB1_0223 binding-protein-dependent transporter inner membrane component Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10213 BAW_10213 BAB1_0224 ABC transporter ATPase ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10214 BAW_10214 BAB1_0225 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10215 BAW_10215 BAB1_0226 glycine betaine ABC transporter substrate-binding protein ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10216 BAW_10216 BAB1_0227 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10217 gdhA BAB1_0228 glutamate dehydrogenase Ronneau et al. 2015. Crit Rev Microbiol. 10:1-19[14]
BAW_10218 BAW_10218 BAB1_0229 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10219 BAW_10219 BAB1_0230 pyridine nucleotide-disulfide oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10220 soxD BAB1_0231 sarcosine oxidase subunit delta Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10221 soxA BAB1_0232-0234 Pseudogene. Frame shift and premature stop codon; similar to BS1330_I0231 (Brucella suis 1330); sarcosine oxidase, alpha subunit Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10222 soxG BAB1_0235 sarcosine oxidase subunit gamma Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10223 BAW_10223 BAB1_0236 amidohydrolase 2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10224 iclR5 BAB1_0237 MarR family regulatory protein Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10225 BAW_10225 BAB1_0238 solute-binding family 1 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10226 BAW_10226 BAB1_0239 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10227 BAW_10227 BAB1_0240 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10228 BAW_10228 BAB1_0241 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10229 BAW_10229 BAB1_0242 mandelate racemase/muconate lactonizing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10230 BAW_10230 BAB1_0243 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10231 BAW_10231 BAB1_0244 oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10232 BAW_10232 BAB1_0245 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10233 BAW_10233 BAB1_0246 short-chain dehydrogenase/reductase SDR:glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10234 BAW_10234 BAB1_0247 fumarylacetoacetate hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10235 BAW_10235 BAB1_0248 mandelate racemase/muconate lactonizing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10236 BAW_10236 BAB1_0249 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10237 BAW_10237 BAB1_0250 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10238 BAW_10238 BAB1_0251 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10239 BAW_10239 BAB1_0252 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10240 BAW_10240 BAB1_0253 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10241 BAW_10241 BAB1_0254 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10242 BAW_10242 BAB1_0255 virulence-associated protein E Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10243 BAW_10243 BAB1_0256 Pseudogene. Frame shift; similar to BMEI169. Hypothetical Membrane Spanning Protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10244 BAW_10244 BAB1_0257 predicted protein similar to BMEI1695; predicted protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10245 BAW_10245 BAB1_0258 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10246 BAW_10246 BAB1_0259 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10247 BAW_10247 BAB1_0260 flagellar protein FlgJ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10248 BAW_10248 BAB1_0261 Pseudogene. Frame shift; similar to BMEI1691. Predicted Membrane Spanning Protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10249 BAW_10249 BAB1_0263 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10250 BAW_10250 BAB1_0264 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10251 BAW_10251 BAB1_0265 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10252 BAW_10252 BAB1_0266 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10253 BAW_10253 BAB1_0267 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10254 BAW_10254 BAB1_0268 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10255 BAW_10255 BAB1_0269 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10256 BAW_10256 BAB1_0270 zinc-dependent metallopeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10257 BAW_10257 BAB1_0271 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10258 BAW_10258 BAB1_0272 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10259 BAW_10259 BAB1_0273 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10260 BAW_10260 BAB1_0274 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10261 BAW_10261 BAB1_0275 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10262 BAW_10262 BAB1_0276 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10263 BAW_10263 BAB1_0277 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10264 BAW_10264 BAB1_0278 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10265 BtpA BAB1_0279 predicted protein Type IV secreted effector with the ability to interfere with TLR-2 signal transduction Salcedo et al. 2008. PLoS Pathog. 4:e21 10.1371[15]
BAW_10266 BAW_10266 BAB1_0280 zinc-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10267 maf-1 BAB1_0281 Maf-like protein Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10268 infA BAB1_0282 translation initiation factor IF-1 stimulates the activities of the other two initiation factors; IF-2 and IF-3 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10269 BAW_10269 BAB1_0283 low molecular weight phosphotyrosine protein phosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10270 BAW_10270 BAB1_0284 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10271 hisD BAB1_0285 histidinol dehydrogenase catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidinebiosynthesis; functions as a dimer Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10272 BAW_10272 BAB1_0286 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10273 murA BAB1_0287 UDP-N-acetylglucosamine 1-carboxyvinyltransferase adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10274 BAW_10274 BAB1_0288 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10275 BAW_10275 BAB1_0289-0290 Pseudogene. Frame shift; similar to BS1330_I0259 (Brucella suis 1330); BRO family protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10276 BAW_10276 BAB1_0291 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10277 BAW_10277 BAB1_0292 site-specific recombinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10278 BAW_10278 BAB1_0293 Pseudogene. Important deletion near 3' end; similar to BMEI0903 (Brucella melitensis 16M) and BS1330_I0262 (Brucella suis 1330); conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10279 BAW_10279 BAB1_1102 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10280 BAW_10280 BAB1_0294 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10281 BAW_10281 BAB1_0295 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10282 BAW_10282 BAB1_0296 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10283 ureD-1 BAB1_0297 urease accessory protein UreD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10284 ureA BAB1_0298 urease subunit gamma UreA; with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide;nickel metalloenzyme; accessory proteins UreD; UreE; UreF; and UreG are necessary for assembly of the metallocenter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10285 ureB BAB1_0299 urease subunit beta ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pyloriandYersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity; optimum growth; resistance to low-pH killing in-vitro and persistence in-vivo; while the other operon does not seem to be active Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10286 ureC BAB1_0300 urease subunit alpha ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pyloritheammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10287 ureE BAB1_0301 urease accessory protein UreE involved in the assembly of the urease metallocenter; possible nickel donor Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10288 BAW_10288 BAB1_0302 urease accessory protein UreF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10289 ureG-1 BAB1_0303 urease accessory protein UreG Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10290 cenK BAB1_0304 histidine kinase A Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10291 BAW_10291 BAB1_0305 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10292 BAW_10292 BAB1_0306 transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10293 BAW_10293 BAB1_0307 acriflavin resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10294 dhT BAB1_0309 Pseudogene. Premature stop codon. Amidohydrolase; similar to BS1330_I0279 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10295 BAW_10295 BAB1_0310 allantoate amidohydrolase allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; theallantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids; ammonia; and carbon dioxide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10296 tetR6 BAB1_0311 transcriptional regulator TetR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10297 BAW_10297 BAB1_0312 Pseudogene. Frame shift. MutT/nudix family protein; similar to BS1330_I0282 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10298 BAW_10298 BAB1_0313 dihydropyrimidine dehydrogenase catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracilandthymine to the corresponding 5;6-dihydropyrimidines Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10299 BAW_10299 BAB1_0314 putative oxidoreductase function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases whichtransfer electrons from NADPH to an acceptor protein or protein domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10300 BAW_10300 BAB1_0315 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10301 pgi BAB1_0316 glucose-6-phosphate isomerase functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10302 BAW_10302 BAB1_0317 arginine/ornithine transport operon protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10303 BAW_10303 BAB1_0318 thiol (cysteine) protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10304 BAW_10304 BAB1_0319 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10305 fadD BAB1_0320 long-chain-fatty-acid—CoA ligase activates fatty acids by binding to coenzyme A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10306 tetR8 BAB1_0321 transcriptional regulator TetR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10307 BAW_10307 BAB1_0322 secretion protein HlyD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10308 BAW_10308 BAB1_0323 acriflavin resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10309 BAW_10309 BAB1_0324 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10310 BAW_10310 BAB1_0325 glutamate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10311 BAW_10311 BAB1_0326 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10312 BAW_10312 BAB1_0327 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10313 phoR BAB1_0328 ATPase-like ATP-binding protein Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10314 gcrA BAB1_0329 predicted protein Holtzendorff et al. 2004. Science. 304(5673):983-7[16]
BAW_10315 BAW_10315 BAB1_0330 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10316 argD BAB1_0331 acetylornithine transaminase protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10317 BAW_10317 BAB1_0332 ornithine carbamoyltransferase catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10318 hslO BAB1_0333 Hsp33-like chaperonin becomes active under oxidative stress; four conserved cysteines bind a zinc atom when theyarein thereduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines; release of zinc; and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10319 apaG BAB1_0334 magnesium transporter apaG protein associated with Co2+ and Mg2+ efflux Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10320 metZ BAB1_0335 O-succinylhomoserine sulfhydrylase catalyzes the conversion of O-succinylhomoserine and sulfide to homocysteine; second step in methionine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10321 BAW_10321 BAB1_0336 2'-deoxycytidine 5'-triphosphate deaminase Catalyzes the deamination of dCTP to form dUTP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10322 araC1 BAB1_0337 helix-hairpin-helix DNA-binding domain-containing protein Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10323 BAW_10323 BAB1_0338 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10324 BAW_10324 BAB1_0339 Allergen V5/Tpx-1-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10325 BAW_10325 BAB1_0340 XRE family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10326 pyrD BAB1_0341 dihydroorotate dehydrogenase 2 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; usesaflavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus; which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10327 BAW_10327 BAB1_0342 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10328 BAW_10328 BAB1_0343 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10329 pip BAB1_0344 proline iminopeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10330 prlR BAB1_0345 LuxR family regulatory protein Hallez et al. 2007. EMBO J. 26(5):1444-55;Mirabella et al. 2012. Microbiology. 58(Pt 10):2642-51[17]
BAW_10331 prlS BAB1_0346 Na+/solute symporter Hallez et al. 2007. EMBO J. 26(5):1444-55;Mirabella et al. 2012. Microbiology. 58(Pt 10):2642-51
BAW_10332 BAW_10332 BAB1_0347 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10333 mscL BAB1_0348 mechanosenitive ion channel protein MscL homopentamer; channel that opens in response to pressure or hypoosmotic shock Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10334 hemA BAB1_0349 5-aminolevulinate synthase catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10335 BAW_10335 BAB1_0350 polysaccharide deacetylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10336 BAW_10336 BAB1_0351 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10337 BAW_10337 BAB1_0352 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10338 BAW_10338 BAB1_0353 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10339 lysR2 BAB1_0354 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10340 BAW_10340 BAB1_0355 murein hydrolase transporter LrgA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10341 BAW_10341 BAB1_0356 LrgB-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10342 BAW_10342 BAB1_0357 Pseudogene. Internal deletion of 33bp; predicted protein; similar to BS1330_I0328 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10343 BAW_10343 BAB1_0358 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10344 panC BAB1_0359 pantoate—beta-alanine ligase catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10345 panB BAB1_0360 3-methyl-2-oxobutanoate hydroxymethyltransferase catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5;10-methylenetetrahydrofolateand 3-methyl-2-oxobutanoate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10346 fpr BAB1_0361 ferredoxin-NADP reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10347 BAW_10347 BAB1_0362 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10348 nspC BAB1_0363 carboxynorspermidine decarboxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10349 BAW_10349 BAB1_0364 saccharopine dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10350 BAW_10350 BAB1_0365 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10351 PrpB BAB1_0366 ATP/GTP-binding domain-containingprotein Spera et al. 2006. Proc Natl Acad Sci U S A. 103(44):16514-9[18]
BAW_10352 BAW_10352 BAB1_0367 Pseudogene. 5' end deletion; similar to BS1330_I0340 (Brucella suis 1330); multidrug resistance protein NorM, putative Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10353 BAW_10353 BAB1_0368 invasion protein B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10354 tcdS BAB1_0369 histidine kinase Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10355 tcdR BAB1_0370 LuxR family regulatory protein Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10356 BAW_10356 BAB1_0371 predicted protein similar to BR0343; conserved predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10357 BAW_10357 BAB1_0372 C4-dicarboxylate ABC transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10358 BAW_10358 BAB1_0373 ABC transporter susbstrate-bindingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10359 BAW_10359 BAB1_0374 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10360 BAW_10360 BAB1_0375 polysaccharide deacetylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10361 BAW_10361 BAB1_0376 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10362 BAW_10362 BAB1_0377 molybdopterin dehydrogenase FAD-binding subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10363 BAW_10363 BAB1_0378 xanthine dehydrogenase similar to BS1330_I0351 (Brucella suis 1330); xanthine dehydrogenase Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10364 BAW_10364 BAB1_0380 chaperone XdhC Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10365 BAW_10365 BAB1_0381 Pseudogene. Frame shift; similar to BS1330_I0353 (Brucella suis 1330); LysR substrate binding domain Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10366 BAW_10366 BAB1_0382 cystein desulfurase corresponds to BS1330_I0354 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10367 BAW_10367 BAB1_0383 guanine deaminase Catalyzes the deamination of guanine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10368 BAW_10368 BAB1_0384 hydroxypyruvate reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10369 ccoS BAB1_0385 cytochrome oxidase maturation protein cbb3-type Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10370 BAW_10370 BAB1_0386 nitrogen fixation protein FixI Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10371 BAW_10371 BAB1_0387 nitrogen fixation protein FixH Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10372 BAW_10372 BAB1_0388 nitrogen fixation protein FixG Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10373 ccoP BAB1_0389 cytochrome c heme-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10374 ccoQ BAB1_0390 cytochrome c oxidase; cbb3-type; CcoQ subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10375 ccoO BAB1_0391 cbb3-type cytochrome c oxidase subunit II CcoO; FixO Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10376 ccoN BAB1_0392 cbb3-type cytochrome c oxidase subunit I CcoN; FixN Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10377 fur BAB1_0393 ferric-uptake regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10378 BAW_10378 BAB1_0394 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10379 BAW_10379 BAB1_0395 DSBA oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10380 BAW_10380 BAB1_0396-0397 Pseudogene. Frame shift; similar to BS1330_I0368 (Brucella suis 1330); predicted Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10381 BAW_10381 BAB1_0398 methylated-DNA-protein cysteine S-methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10382 BAW_10382 BAB1_0399 ArsC family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10383 BAW_10383 BAB1_0400 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10384 BAW_10384 BAB1_0401 MFS transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10385 bacA BAB1_0402 transporter in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA;TonB; andExbB/D in this capacity; in Sinorhizobium meliloti; BacA is essential and required for symbiosis; defects appear to affect the cell envelope LeVier et al. 2000. Science 287:2492-2493[19]
BAW_10386 BAW_10386 BAB1_0403 polysaccharide deacetylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10387 BAW_10387 BAB1_0404 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10388 engA BAB1_0405 GTP-binding protein EngA EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targetswith tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10389 BAW_10389 BAB1_0406 heat shock protein Hsp70 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10390 BAW_10390 BAB1_0407 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10391 BAW_10391 BAB1_0408 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10392 BAW_10392 BAB1_0409 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10393 atpB BAB1_0410 ATP synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10394 atpl BAB1_0411 F0F1 ATP synthase subunit A Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10395 atpE BAB1_0412 F0F1 ATP synthase subunit C Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10396 atpX BAB1_0413 F0F1 ATP synthase subunit B' Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B'is partofthe membrane proton channel. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10397 atpF BAB1_0414 F0F1 ATP synthase subunit B Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10398 rnhB BAB1_0415 ribonuclease HII RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10399 BAW_10399 BAB1_0416 radical SAM protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10400 BAW_10400 BAB1_0417 glycosyl transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10401 BAW_10401 BAB1_0418 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10402 BAW_10402 BAB1_0419 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10403 BAW_10403 BAB1_0420 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10404 BAW_10404 BAB1_0421 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10405 BAW_10405 BAB1_0422 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10406 ispE BAB1_0423 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10407 BAW_10407 BAB1_0424 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10408 BAW_10408 BAB1_0425 Clp protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10409 BAW_10409 BAB1_0426 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10410 BAW_10410 BAB1_0427 cytosine-N4-specific DNA-methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10411 BAW_10411 BAB1_0428 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10412 BAW_10412 BAB1_0429 polyprenyl synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10413 BAW_10413 BAB1_0430 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10414 glyQ BAB1_0431 glycyl-tRNA synthetase subunit alpha glycine—tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10415 BAW_10415 BAB1_0432 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10416 glyS BAB1_0433 glycyl-tRNA synthetase subunit beta glycine—tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10417 BAW_10417 BAB1_0434 Sua5/YciO/YrdC/YwlC family protein:SUA5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10418 BAW_10418 BAB1_0435 FAD linked oxidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10419 BAW_10419 BAB1_0436 plasmid stabilization system protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10420 BAW_10420 BAB1_0437 CopG family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10421 BAW_10421 BAB1_0438 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10422 BAW_10422 BAB1_0439 enoyl-CoA hydratase Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10423 BAW_10423 BAB1_0440 acyl-CoA dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618[20]
BAW_10424 cgsB BAB1_0441 diguanylate cyclase Petersen et al. 2011. J Bacteriol. 193:5683-5691;
BAW_10425 purD BAB1_0442 phosphoribosylamine—glycine ligase catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamineandglycine in purine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10426 ubiA BAB1_0443 4-hydroxybenzoate polyprenyltransferase UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptorswith hydrophobic ring structures in the biosynthesis of respiratory quinones; hemes; chlorophylls; vitamin E; and shikonin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10427 pdxH BAB1_0444 pyridoxamine 5'-phosphate oxidase catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10428 BAW_10428 BAB1_0445 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10429 BAW_10429 BAB1_0446 heat shock protein DnaJ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10430 fabI-1 BAB1_0447 enoyl-(acyl carrier protein) reductase Catalyzes a key regulatory step in fatty acid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10431 BAW_10431 BAB1_0448 phosphoglycerate/bisphosphoglycerate mutase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10432 BAW_10432 BAB1_0449 cold-shock protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10433 BAW_10433 BAB1_0450 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10434 BAW_10434 BAB1_0451 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10435 BAW_10435 BAB1_0452 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10436 BAW_10436 BAB1_0453 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10437 aroC BAB1_0454 chorismate synthase catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromaticaminoacid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10438 BAW_10438 BAB1_0455 3;4-dihydroxy-2-butanone 4-phosphate synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10439 BAW_10439 BAB1_0456 histone deacetylase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10440 xseB BAB1_0457 exodeoxyribonuclease VII small subunit catalyzes the bidirectional exonucleolytic cleavage of DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10441 BAW_10441 BAB1_0458 DedA family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10442 BAW_10442 BAB1_0459 transglycosylase-associated protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10443 BAW_10443 BAB1_0460 ribosomal protein P2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10444 BAW_10444 BAB1_0461 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10445 dxs BAB1_0462 1-deoxy-D-xylulose-5-phosphate synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10446 tlyA BAB1_0463 hemolysin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10447 BAW_10447 BAB1_0464 RNA methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10448 BAW_10448 BAB1_0465 lysine decarxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10449 BAW_10449 BAB1_0466 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10450 BAW_10450 BAB1_0467 peptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10451 BAW_10451 BAB1_0468 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10452 Psd BAB1_0469 phosphatidylserine decarboxylase catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine Bukata et al. 2008. J Bacteriol. 190(24):8197-203[21]
BAW_10453 pssA BAB1_0470 CDP-alcohol phosphatidyltransferase Bukata et al. 2008. J Bacteriol. 190(24):8197-203;
BAW_10454 BAW_10454 BAB1_0471 short-chain dehydrogenase/reductase SDR:glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10455 purF BAB1_0472 amidophosphoribosyltransferase Catalyzes first step of the de novo purine nucleotide biosynthetic pathway Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10456 BAW_10456 BAB1_0473 colicin V production protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10457 radA BAB1_0474 DNA repair protein RadA Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination ofdonor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10458 dnaB BAB1_0475 replicative DNA helicase unwinds double stranded DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10459 cfa BAB1_0476 cyclopropane-fatty-acyl-phospholipid synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10460 rplI BAB1_0477 50S ribosomal protein L9 in Escherichia coli this protein is wrapped around the base of the L1 stalk Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10461 BAW_10461 BAB1_0478 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10462 rpsR BAB1_0479 30S ribosomal protein S18 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10463 rpsF BAB1_0480 30S ribosomal protein S6 binds cooperatively with S18 to the S15-16S complex; allowing platform assembly to continuewith S11and S21 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10464 BAW_10464 BAB1_0481 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10465 fabD BAB1_0482 malonyl CoA-acyl carrier protein transacylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10466 fabG BAB1_0483 3-ketoacyl-ACP reductase catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10467 acpP BAB1_0484 acyl carrier protein carries the fatty acid chain in fatty acid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10468 BAW_10468 BAB1_0485 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10469 BAW_10469 BAB1_0486 3-oxoacyl-(acyl carrier protein) synthase II FabF; beta-ketoacyl-ACP synthase II; KASII; catalyzes a condensation reaction in fatty acidbiosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10470 mitG BAB1_0487 4-amino-4-deoxychorismate lyase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10471 BAW_10471 BAB1_0488 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10472 gmk BAB1_0489 guanylate kinase Essential for recycling GMP and indirectly; cGMP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10473 BAW_10473 BAB1_0490 protease TldD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10474 BAW_10474 BAB1_0491 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10475 BAW_10475 BAB1_0492 cytochrome c oxidase subunit II Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10476 coxA BAB1_0493 cytochrome c oxidase subunit I Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10477 ctaB BAB1_0494 Pseudogene. Truncated; 3' end deletion of 105 bp; similar to BS1330_I0470; protoheme IX farnesyltransferase Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10478 ctaG BAB1_0495-0496 Pseudogene. Frame shift; similar to BS1330_I0472. Cytochrome c oxidase assembly protein Ctag KO: K02258 cytochrome c oxidase subunit XI assembly protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10479 coxC BAB1_0497 cytochrome c oxidase subunit III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10480 BAW_10480 BAB1_0498-0499 Pseudogene. Internal deletion and frame shift; similar to BS1330_I0474 (Brucella suis 1330); conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10481 BAW_10481 BAB1_0500 Surf1 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10482 ispH BAB1_0501 4-hydroxy-3-methylbut-2-enyl diphosphate reductase catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyldiphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10483 thrB BAB1_0502 homoserine kinase catalyzes the formation of O-phospho-L-homoserine from L-homoserine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10484 rnhA BAB1_0503 ribonuclease H An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10485 BAW_10485 BAB1_0504 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10486 BAW_10486 BAB1_0505 30S ribosomal protein S7 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10487 BAW_10487 BAB1_0506 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10488 pdeA BAB1_0507 diguanylate cyclase Petersen et al. 2011. J Bacteriol. 193:5683-5691;
BAW_10489 BAW_10489 BAB1_0508 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10490 BAW_10490 BAB1_0509 insulinase-like peptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10491 thrC BAB1_0510 threonine synthase catalyzes the formation of L-threonine from O-phospho-L-homoserine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10492 BAW_10492 BAB1_0511 putative lipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10493 bpdB BAB1_0512 diguanylate phosphodiesterase Petersen et al. 2011. J Bacteriol. 193:5683-5691;
BAW_10494 BAW_10494 BAB1_0513 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10495 BAW_10495 BAB1_0514 HAD family hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10496 BAW_10496 BAB1_0515 Cl- channel voltage-gated family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10497 ccrM BAB1_0516 modification methylase Robertson et al. 2000. J Bacteriol.182(12):3482-9[22]
BAW_10498 BAW_10498 BAB1_0517 2-haloalkanoic acid dehalogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10499 mutY BAB1_0518 adenine glycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10500 BAW_10500 BAB1_0519 adenine glycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10501 BAW_10501 BAB1_0520 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10502 BAW_10502 BAB1_0521 DSBA oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10503 smc BAB1_0522 chromosome segregation protein SMC Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10504 BAW_10504 BAB1_0523 Pseudogene. Frame shift; similar to BS1330_I0499 (Brucella suis 1330); cobalt-zinc-cadmium resistance protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10505 BAW_10505 BAB1_0524 glyoxalase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10506 ppdK BAB1_0525 pyruvate phosphate dikinase catalyzes the formation of phosphoenolpyruvate from pyruvate. A ppdK 2308 B abortus mutant is attenuated in the mouse model Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Zuniga-Ripa et al. 2014. J. Bacteriol. 96(16):3045-57
BAW_10507 BAW_10507 BAB1_0526 polysaccharide deacetylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10508 ifoP BAB1_0527 marker of new poles Deghelt et al. 2014. Nat Commun.9;5:4366[23]
BAW_10509 BAW_10509 BAB1_0528 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10510 BAW_10510 BAB1_0529 beta-lactamase-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10511 BAW_10511 BAB1_0530 BioY protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10512 BAW_10512 BAB1_0531 ureidoglycolate hydrolase catalyzes the formation of glyoxylate from (S)-ureidoglycolate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10513 BAW_10513 BAB1_0532 5-hydroxyisourate hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10514 BAW_10514 BAB1_0533 ribonuclease III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10515 wbkD BAB1_0534 polysaccharide biosynthesis protein CapD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10516 wbkF BAB1_0535 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10517 BAW_10517 BAB1_0536 transcriptional regulator LacI Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10518 BAW_10518 BAB1_0537 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10519 BAW_10519 BAB1_0538 DNA binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10520 BAW_10520 BAB1_0539 integrase catalytic subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10521 wbkC BAB1_0540 GDP-mannose 4;6-dehydratase Godfroid et al. 2000. Res Microbiol. 151(8):655-68[24]
BAW_10522 wbkB BAB1_0541 perosamine synthetase WbkB Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10523 wzt BAB1_0542 ABC transporter ATPase Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10524 wzm BAB1_0543 acriflavin ABC transporter Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10525 per BAB1_0544 perosamine synthetase Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10526 gmd BAB1_0545 GDP-mannose 4;6-dehydratase Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10527 BAW_10527 BAB1_0547 transposase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10528 BAW_10528 BAB1_0548 transposase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10529 BAW_10529 BAB1_0549 transposase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10530 BAW_10530 BAB1_0552 transposase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10531 wbkA BAB1_0553 group 1 glycosyl transferase Godfroid et al. 2000. Res Microbiol. 151(8):655-68;
BAW_10532 BAW_10532 BAB1_0554 IS5 family transposase orfA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10533 BAW_10533 BAB1_0555 IS5 family transposase orfB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10534 BAW_10534 BAB1_0556 Pseudogene. Premature stop codon; similar to BMEI1401 (Brucella melitensis 16M); transposase Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10535 BAW_10535 BAB1_0557 Pseudogene. sequencing gap -NNNNN-; ISBm1, transposase orfA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10536 BAW_10536 BAB1_0558 Pseudogene. sequencing gap -NNNNN-; transposase IS4 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10537 BAW_10537 BAB1_0559 transposase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10538 manB BAB1_0560 phosphoglucomutase/phosphomannomutase Gonzalez et al. 2008. PLoS One. 3(7):e2760[25]
BAW_10539 manC BAB1_0561 mannose-6-phosphate isomerase Gonzalez et al. 2008. PLoS One. 3(7):e2760;
BAW_10540 manA BAB1_0562 mannose-6-phosphate isomerase not pseudogene in 9-941: similar to BR0539; mannose-6-phosphate isomerase Gonzalez et al. 2008. PLoS One. 3(7):e2760;
BAW_10541 wbkE BAB1_0563 group 1 glycosyl transferase Gonzalez et al. 2008. PLoS One. 3(7):e2760;
BAW_10542 BAW_10542 BAB1_0564 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10543 BAW_10543 BAB1_0565 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10544 rbsC-1 BAB1_0566 ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10545 rbsB-1 BAB1_0567 ABC trasnsporter substrate-bindingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10546 BAW_10546 BAB1_0568 AP endonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10547 BAW_10547 BAB1_0569 oxidoreductase similar to BR0546; oxidoreductase; Gfo/Idh/MocA family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10548 BAW_10548 BAB1_0570 xylose isomerase catalyzes the interconversion of D-xylose to D-xylulose Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10549 xylB BAB1_0571 carbohydrate kinase:xylulokinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10550 BAW_10550 BAB1_0572 transcriptional regulator LacI Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10551 BAW_10551 BAB1_0573-0574 Pseudogene. Internal deletion and frame shift; similar to BS1330_I0546 (Brucella suis 1330); AraC family transcriptional regulator Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10552 BAW_10552 BAB1_0575 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10553 BAW_10553 BAB1_0576 betaine aldehyde dehydrogenase catalyzes the formation of betaine from betaine aldehyde Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10554 BAW_10554 BAB1_0577 choline dehydrogenase catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine. Regulated by AbcR sRNAin B abortus 2308 (Caswell CC et al. 2012 Mol Microbiol. Transcription is regulated when B. melitensis is infecting HeLa cells (Rosetti CA et al. 2011 Microb Pathog). Absent in B abortus 9-941 and B melitensis 16M according to Tsolis R et al. 2009 PLoS ONe Caswell et al. 2012. Mol Microbiol.85(2):345-60[26]
BAW_10555 tetR9 BAB1_0578 transcriptional regulator BetI HTH-type; bet1; Repressor involved in choline regulation of the bet genes Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10556 BAW_10556 BAB1_0579 asparaginase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10557 BAW_10557 BAB1_0580 transcription elongation factor GreA/GreB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10558 BAW_10558 BAB1_0581 cytochrome C biogenesis protein CcmH Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10559 BAW_10559 BAB1_0582 AbrB family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10560 BAW_10560 BAB1_0583 Mg2+ transporter protein; CorA-like Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10561 BAW_10561 BAB1_0584-0585 Pseudogene. Double frame shift; similar to BS1330_I0556 (Brucella suis 1330). Bacterial regulatory proteins, AsnC family:Bacterial regulatory protein, GntR family Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10562 BAW_10562 BAB1_0586 Pseudogene. Frame shift and 27bp internal deletion; similar to BS1330_I0557 (Brucella suis 1330); cyanate transport protein CynX Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10563 BAW_10563 BAB1_0587 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10564 BAW_10564 BAB1_0588 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10565 BAW_10565 BAB1_0589 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10566 BAW_10566 BAB1_0590 HAD family hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10567 sodA BAB1_0591 manganese and iron superoxide dismutase Martin et al. 2012. Microbiology 158:1767-1774[27]
BAW_10568 BAW_10568 BAB1_0592 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10569 BAW_10569 BAB1_0593 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10570 mucR BAB1_0594 transcriptional regulator MucR Mirabella et al. 2013. J Bacteriol. 195(3):453-65;Caswell et al. 2013. Infect Immun. 81(4):1040-51[28]
BAW_10571 BAW_10571 BAB1_0595 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10572 BAW_10572 BAB1_0596 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10573 BAW_10573 BAB1_0597 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10574 BAW_10574 BAB1_0598 amidase catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10575 BAW_10575 BAB1_0599 cysteine desufuration protein SufE Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10576 BAW_10576 BAB1_0600 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10577 divJ BAB1_0601 histidine kinase Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10578 BAW_10578 BAB1_0602 peptidoglycan binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10579 BAW_10579 BAB1_0603 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10580 BAW_10580 BAB1_0604 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10581 BAW_10581 BAB1_0605 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10582 BAW_10582 BAB1_0606 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10583 BAW_10583 BAB1_0607 penicillin-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10584 BAW_10584 BAB1_0608 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10585 BAW_10585 BAB1_0609 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10586 BAW_10586 BAB1_0610 portal protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10587 BAW_10587 BAB1_0611 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10588 BAW_10588 BAB1_0612 peptidase U35 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10589 BAW_10589 BAB1_0613 HK97 family phage major capsid protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10590 BAW_10590 BAB1_0614 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10591 BAW_10591 BAB1_0615 phage head-tail adaptor Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10592 BAW_10592 BAB1_0616 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10593 BAW_10593 BAB1_0617 tail protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10594 BAW_10594 BAB1_0618 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10595 BAW_10595 BAB1_0619 phage minor tail protein H Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10596 BAW_10596 BAB1_0620 glycoside hydrolase family 24 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10597 BAW_10597 BAB1_0621-0622 Pseudogene. Frame shift; similar to BS1330_I0595 (Brucella suis 1330) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10598 BAW_10598 BAB1_0623 NLP/P60 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10599 BAW_10599 BAB1_0624-0625 Pseudogene. Frame shift and premature stop codon; similar to BMEI1341. Phage Host Specificity Protein, RNA-binding region RNP-1 (RNA recognition motif) Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10600 BAW_10600 BAB1_0626 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10601 BAW_10601 BAB1_0627 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10602 feuP BAB1_0628 transcriptional regulator Dorrell et al. 1998. FEMS Microbiol Lett. 162(1):143-50[29]
BAW_10603 feuQ BAB1_0629 histidine kinase Dorrell et al. 1998. FEMS Microbiol Lett. 162(1):143-50;
BAW_10604 BAW_10604 BAB1_0630 outer membrane lipoprotein-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10605 BAW_10605 BAB1_0631 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10606 ccmE BAB1_0632 cytochrome c-type biogenesis protein CcmE CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers itto newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10607 ccmF BAB1_0633 cytochrome c-type biogenesis protein CcmF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10608 BAW_10608 BAB1_0634 cytochrome C biogenesis protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10609 htrA BAB1_0635 serine protease family protein Roop et al. 1994. Infect. Immun. 62:1000-1007[30]
BAW_10610 tccR BAB1_0636 PhoB family transcriptional regulator Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10611 tccS BAB1_0637 histidine kinase Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10612 glnE BAB1_0638 bifunctional glutamine-synthetaseadenylyltransferase/deadenyltransferase catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes thereverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10613 wadA BAB1_0639 glycosyl transferase family O-antigen polymerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10614 pleC BAB1_0640 histidine kinase Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_10615 pepN BAB1_0641 aminopeptidase N Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10616 BAW_10616 BAB1_0642 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10617 BAW_10617 BAB1_0643 major facilitator transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10618 BAW_10618 BAB1_0644 DNA polymerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10619 BAW_10619 BAB1_0645 electron transfer flavoprotein-ubiquinone oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10620 BAW_10620 BAB1_0646 endonuclease/exonuclease/phosphatase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10621 amn BAB1_0647 AMP nucleosidase Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10622 BAW_10622 BAB1_0648 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10623 BAW_10623 BAB1_0649 glutathione S-transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10624 BAW_10624 BAB1_0650 glycerol-3-phosphate ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10625 BAW_10625 BAB1_0651 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10626 BAW_10626 BAB1_0652 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10627 BAW_10627 BAB1_0653 membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10628 BAW_10628 BAB1_0654 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10629 BAW_10629 BAB1_0655 antifreeze protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10630 BAW_10630 BAB1_0656 oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10631 BAW_10631 BAB1_0657 histidinol-phosphate aminotransferase catalyzes the formation of histidinol phosphate and 2-oxoglutarate from glutamate and imidazoleacetol-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10632 BAW_10632 BAB1_0658 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10633 omp2a BAB1_0659 porin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10634 omp2b BAB1_0660 Omp2b; porin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10635 BAW_10635 BAB1_0661 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10636 BAW_10636 BAB1_0662 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10637 BAW_10637 BAB1_0663 ATP synthase subunit E Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10638 BAW_10638 BAB1_0664 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10639 dapA BAB1_0665 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10640 BAW_10640 BAB1_0666 dihydrodipicolinate synthase catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvateinlysineand diaminopimelate biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10641 smpB BAB1_0667 SsrA-binding protein binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appearstofunction in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10642 BAW_10642 BAB1_0668 uracil-DNA glycosylase superfamilyprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10643 BAW_10643 BAB1_0669 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10644 BAW_10644 BAB1_0670 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10645 ropZ BAB1_0671 DNA-directed RNA polymerase subunit omega Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit therebyfacilitating its interaction with the beta and alpha subunits Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10646 rsh BAB1_0672 GTP pyrophosphokinase Dozot et al. 2006. Cell Microbiol.8(11):1791-802[31]
BAW_10647 pyrE BAB1_0673 orotate phosphoribosyltransferase involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphatetoorotate and 5-phospho-alpha-D-ribose 1-diphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10648 fnr BAB1_0674 Crp family regulatory protein Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10649 BAW_10649 BAB1_0675 coproporphyrinogen III oxidase catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10650 BAW_10650 BAB1_0676 fosmidomycin resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10651 araC5 BAB1_0677 AraC family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10652 bspA BAB1_0678 type IV secretion effector Myeni et al. 2013. PLoS Pathog. 9(8):e1003556[32]
BAW_10653 acpS BAB1_0679 4'-phosphopantetheinyl transferase Catalyzes the formation of holo-ACP; which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10654 BAW_10654 BAB1_0680 signal peptidase S26A:Signal peptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10655 rnc BAB1_0681 ribonuclease III cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNAregions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10656 BAW_10656 BAB1_0682 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10657 era BAB1_0683 GTP-binding protein Era Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essentialproteininEscherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10658 recO BAB1_0684 DNA repair protein RecO involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-bindingprotein and facilitate the production of RecA-coated ssDNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10659 BAW_10659 BAB1_0685 tyrosine specific protein phosphatase and dual specificity protein phosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10660 BAW_10660 BAB1_0686 hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10661 BAW_10661 BAB1_0687 glycine cleavage T protein (aminomethyl transferase) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10662 pyrC-1 BAB1_0688 dihydroorotase Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolicintermediate is required for the biosynthesis of pyrimidine nucleotides Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10663 BAW_10663 BAB1_0689 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10664 BAW_10664 BAB1_0690 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10665 BAW_10665 BAB1_0691 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10666 BAW_10666 BAB1_0692 DNA mismatch repair protein MutT Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10667 BAW_10667 BAB1_0693 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10668 BAW_10668 BAB1_0694 lysine exporter protein LysE/YggA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10669 BAW_10669 BAB1_0695 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10670 BAW_10670 BAB1_0696 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10671 cysS BAB1_0697 cysteinyl-tRNA synthetase catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10672 BAW_10672 BAB1_0698 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10673 BAW_10673 BAB1_0699 2-isopropylmalate synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10674 BAW_10674 BAB1_0700 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10675 BAW_10675 BAB1_0701 putative alpha-isopropylmalate/homocitrate synthase family transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10676 BAW_10676 BAB1_0702 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10677 BAW_10677 BAB1_0703 peptidase M23/M37 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10678 ksgA BAB1_0704 dimethyladenosine transferase catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet)totwo adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10679 pdxA BAB1_0705 4-hydroxythreonine-4-phosphate dehydrogenase catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyricacid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10680 BAW_10680 BAB1_0706 peptidyl-prolyl cis-trans isomerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10681 lptD BAB1_0707 organic solvent tolerance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10682 lptG BAB1_0708 YjgP/YjgQ permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10683 lptf BAB1_0709 YjgP/YjgQ permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10684 BAW_10684 BAB1_0710 leucyl aminopeptidase catalyzes the removal of N-terminal amino acids preferably leucine from various peptides Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10685 BAW_10685 BAB1_0711 DNA polymerase III subunit chi binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loadercomplex and the SSB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10686 bspB BAB1_0712 type IV secretion effector This protein mediates inhibition of host secretion Myeni et al. 2013. PLoS Pathog. 9(8):e1003556;
BAW_10687 BAW_10687 BAB1_0713 glycosyl transferase family 1 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10688 BAW_10688 BAB1_0714 diguanylate cyclase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10689 ndk BAB1_0715 nucleoside diphosphate kinase catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10690 BAW_10690 BAB1_0716 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10691 moaE BAB1_0717 molybdopterin biosynthesis MoaE Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10692 moaD BAB1_0718 molybdenum cofactor biosynthesis protein MoaD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10693 pgsA BAB1_0719 CDP-alcohol phosphatidyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10694 uvrC BAB1_0720 excinuclease ABC subunit C The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC bothincisesthe 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10695 BAW_10695 BAB1_0721 short chain dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10696 BAW_10696 BAB1_0722 Outer membrane protein Omp25 precursor Major member of the group 3 of outer membrane proteins. Contains a common site of signal peptide cleavage (AXAAD). Its function is unknown and its role in virulence is controversial. Similar to B. suis 1330 BS1330_RS03235 and B. melitensis 16M BME_RS06290. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618; Guzmán-Verri et al. 2002. Proc Natl Acad Sci USA. 99: 12375-80;[33] Sahli et al. 2003. Infect Immun. 71:4326-32; Manterola et al.2007. Infect Immun. 4867-74[34]
BAW_10697 BAW_10697 BAB1_0723 glutathione S-transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10698 BAW_10698 BAB1_0724 ribonuclease T2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10699 BAW_10699 BAB1_0725 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10700 BAW_10700 BAB1_0726 lactate dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10701 BAW_10701 BAB1_0727 membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10702 BAW_10702 BAB1_0728 molybdopterin-binding oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10703 BAW_10703 BAB1_0729 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10704 purN BAB1_0730 phosphoribosylglycinamide formyltransferase glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10705 purM BAB1_0731 phosphoribosylformylglycinamidinecyclo-ligase catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10706 BAW_10706 BAB1_0732 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10707 BAW_10707 BAB1_0733 ATP/GTP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10708 galE BAB1_0734 UDP-glucose 4-epimerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10709 BAW_10709 BAB1_0735 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10710 BAW_10710 BAB1_0736 short-chain dehydrogenase/reductase SDR:glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10711 BAW_10711 BAB1_0737 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10712 lldP BAB1_0738 L-lactate permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10713 BAW_10713 BAB1_0739 ETC complex I subunit region Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10714 BAW_10714 BAB1_0740 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10715 BAW_10715 BAB1_0741 adenylate kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10716 BAW_10716 BAB1_0742 GCN5 family acetyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10717 BAW_10717 BAB1_0743 Cro/CI family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10718 BAW_10718 BAB1_0744 helix-hairpin-helix DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10719 BAW_10719 BAB1_0745 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10720 BAW_10720 BAB1_0746 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10721 BAW_10721 BAB1_0747 integrase catalytic subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10722 BAW_10722 BAB1_0748 Pseudogene. Frame shif; similar to BS1330_I0726 (Brucella suis 1330). ATP/GTP-binding site motif A (P-loop)/ATPase AAA Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10723 BAW_10723 BAB1_0750 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10724 BAW_10724 BAB1_0751 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10725 BAW_10725 BAB1_0752 beta and gamma crystallin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10726 BAW_10726 BAB1_0753-0754-0755 Pseudogene. Double premature stop codon; similar to BS1330_I0730 (Brucella suis 1330); conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10727 BtpB BAB1_0756 VirB type IV secreted effector BtpB plays a major role in the modulation of host innate immune response during infection interfering with MyD88 signallig Salcedo et al. 2013. Front Cell Infect Microbiol. 8;3:28[35]
BAW_10728 BAW_10728 BAB1_0757 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10729 BAW_10729 BAB1_0758 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10730 BAW_10730 BAB1_0759 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10731 metC BAB1_0760 cystathionine beta-lyase catalyzes the formation of L-homocysteine from cystathionine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10732 BAW_10732 BAB1_0761 PA-phosphatase-like phosphoesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10733 BAW_10733 BAB1_0762-0763 Pseudogene. Frame shift. Similar to BS1330_I0737 (Brucella suis 1330). Solute-binding protein/glutamate receptor:Bacterial extracellular solute-binding protein, family 3 Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10734 BAW_10734 BAB1_0764 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10735 BAW_10735 BAB1_0765-0766 Pseudogene. Double frame shift; similar to BS1330_I0739 (Brucella suis 1330). General L-amino acid transport system permease protein AapQ KO: K02029 polar amino acid transport system permease protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10736 BAW_10736 BAB1_0767 amino acid ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10737 BAW_10737 BAB1_0768 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10738 BAW_10738 BAB1_0769 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10739 BAW_10739 BAB1_0770 salicylate hydroxylase catalyzes the formation of catechol from salicylate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10740 BAW_10740 BAB1_0771 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10741 ppk BAB1_0772 polyphosphate kinase catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10742 BAW_10742 BAB1_0773 exopolyphosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10743 BAW_10743 BAB1_0774 3'-5' exonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10744 aspS BAB1_0775 aspartyl-tRNA synthetase catalyzes a two-step reaction; first charging an aspartate molecule by linking its carboxylgroup to the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10745 BAW_10745 BAB1_0776 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10746 parC BAB1_0777 DNA topoisomerase IV subunit A decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10747 BAW_10747 BAB1_0778 arginyl-tRNA-protein transferase Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10748 BAW_10748 BAB1_0779 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10749 hemB BAB1_0780 delta-aminolevulinic acid dehydratase catalyzes the formation of porphobilinogen from 5-aminolevulinate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10750 BAW_10750 BAB1_0781 3-hydroxyisobutyryl-CoA hydrolase catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10751 BAW_10751 BAB1_0782 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10752 MdrA BAB1_0783 MarR family regulatory protein MarR-like sodium deoxycholate-responsive activator involved in VirB promoter activation Sieira et al. 2012. J Bacteriol.194(23):6431-40[36]
BAW_10753 BAW_10753 BAB1_0784 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10754 BAW_10754 BAB1_0785 peptidoglycan binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10755 BAW_10755 BAB1_0786 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10756 glyA BAB1_0787 serine hydroxymethyltransferase catalyzes the reaction of glycine with 5;10-methylenetetrahydrofolate to form L-serine andtetrahydrofolate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10757 nrdR BAB1_0788 transcriptional regulator NrdR Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10758 ribD BAB1_0789 cytidine/deoxycytidylate deaminasezinc-binding subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10759 BAW_10759 BAB1_0790 riboflavin synthase subunit alpha catalyzes the formation of riboflavin from 6;7-dimethyl-8-(1-D-ribityl)lumazine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10760 ribH BAB1_0791 6;7-dimethyl-8-ribityllumazine synthase RibE; 6;7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunitof riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2;4(1H;3H)-pyrimidinedione with L-3;4-dihydrohy-2-butanone-4-phosphate to generate 6;6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10761 nusB BAB1_0792 transcription antitermination protein NusB Regulates rRNA biosynthesis by transcriptional antitermination Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10762 hppA BAB1_0793 membrane-bound proton-translocating pyrophosphatase pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; cancleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10763 BAW_10763 BAB1_0794 SmpA/OmlA protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10764 BAW_10764 BAB1_0795 ubiquinol-cytochrome C chaperone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10765 BAW_10765 BAB1_0796 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10766 plsX BAB1_0797 putative glycerol-3-phosphate acyltransferase PlsX involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY Takada et al. 2014. Mol Microbiol. 91(2):242-55[37]
BAW_10767 BAW_10767 BAB1_0798 3-oxoacyl-ACP synthase FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10768 ihfA BAB1_0799 integration host factor subunit alpha This protein is one of the two subunits of integration host factor; a specific DNA-bindingproteinthat functions in genetic recombination as well as in transcriptional and translational control Sieira et al. 2004. Mol Microbiol. 54(3):808-22[38]
BAW_10769 BAW_10769 BAB1_0800 MerR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_10770 sugE BAB1_0801 small multidrug resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10771 BAW_10771 BAB1_0802 UDP-phosphate glucose phosphotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10772 BAW_10772 BAB1_0803 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10773 BAW_10773 BAB1_0804 chromosome partitioning protein ParA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10774 BAW_10774 BAB1_0805 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10775 BAW_10775 BAB1_0806 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10776 BAW_10776 BAB1_0807 cytochrome oxidase assembly Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10777 argC BAB1_0808 N-acetyl-gamma-glutamyl-phosphatereductase catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehydeinarginine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10778 BAW_10778 BAB1_0809 agmatinase catalyzes the formation of putrescine from agmatine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10779 rpsI BAB1_0810 30S ribosomal protein S9 forms a direct contact with the tRNA during translation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10780 rplM BAB1_0811 50S ribosomal protein L13 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10781 BAW_10781 BAB1_0812 phenylacetic acid degradation-likeprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10782 BAW_10782 BAB1_0813 O-acetylhomoserine aminocarboxypropyltransferase catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10783 BAW_10783 BAB1_0814 Pseudogene. Frame shift; similar to BS1330_I0790 (Brucella suis 1330); predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10784 BAW_10784 BAB1_0815 predicted protein similar to BR0795; predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10785 BAW_10785 BAB1_0816 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10786 BAW_10786 BAB1_0817 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10787 BAW_10787 BAB1_0818 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10788 BAW_10788 BAB1_0819 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10789 BAW_10789 BAB1_0820 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10790 BAW_10790 BAB1_0821 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10791 BAW_10791 BAB1_0822 NADH dehydrogenase subunit A Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10792 nuoB BAB1_0823 NADH dehydrogenase subunit B The point of entry for the majority of electrons that traverse the respiratory chain eventuallyresulting in the reduction of oxygen Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10793 nuoC BAB1_0824 NADH dehydrogenase subunit C Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10794 nuoD BAB1_0825 NADH dehydrogenase subunit D Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10795 nuoE BAB1_0826 NADH dehydrogenase subunit E Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10796 nuoF BAB1_0827 NADH dehydrogenase I subunit F part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH; via FMN andiron-sulfur (Fe-S) centers; to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment; which represents the electron input part of NADH dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10797 nuoG BAB1_0828 NADH dehydrogenase subunit G Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10798 nuoH BAB1_0829 NADH dehydrogenase subunit H Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10799 nuoI BAB1_0830 NADH dehydrogenase subunit I Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10800 nuoJ BAB1_0831 NADH dehydrogenase subunit J Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10801 nuoK BAB1_0832 NADH dehydrogenase subunit K Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10802 nuoL BAB1_0833 NADH dehydrogenase subunit L Catalyzes the transfer of electrons from NADH to ubiquinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10803 nuoM BAB1_0834 NADH dehydrogenase subunit M Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10804 nuoN BAB1_0835 NADH dehydrogenase subunit N Catalyzes the transfer of electrons from NADH to quinone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10805 BAW_10805 BAB1_0836 biotin-protein ligase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10806 BAW_10806 BAB1_0837 beta-lactamase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10807 BAW_10807 BAB1_0838 methylmalonyl-CoA epimerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10808 BAW_10808 BAB1_0839 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10809 BAW_10809 BAB1_0840 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10810 proS BAB1_0842 prolyl-tRNA synthetase Catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10811 BAW_10811 BAB1_0843 lipoprotein releasing system; transmembrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10812 lolD BAB1_0844 ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10813 dnaE BAB1_0845 DNA polymerase III subunit alpha Catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotideat atime;main replicative polymerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10814 BAW_10814 BAB1_0846 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10815 bspC BAB1_0847 Brucellasecreted protein C VirB T4SS substrate. Contains a predicted Sec-dependent signal peptide. Localized to the Golgi apparatus when ectopically expressed in HeLa cells Myeni et al. 2013. PLoS Pathog. 9(8):e1003556
BAW_10816 BAW_10816 BAB1_0848-0849-0850 Pseudogene. Double frame shift and premature stop codon; similar to BMEI1134 (Brucella melitensis 16M); extensin like protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10817 rpsD BAB1_0851 30S ribosomal protein S4 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10818 ttcA BAB1_0852 C32 tRNA thiolase catalyzes the thiolation of cytidine 32 in specific tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10819 BAW_10819 BAB1_0853 inositol monophosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10820 BAW_10820 BAB1_0854 Bcr/CflA subfamily drug resistancetransporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10821 BAW_10821 BAB1_0855 glutaredoxin:glutaredoxin-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10822 BAW_10822 BAB1_0856 BOLA-related protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10823 BAW_10823 BAB1_0857 phosphoribosylformylglycinamidinesynthase II catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10824 BAW_10824 BAB1_0858 putative lipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10825 BAW_10825 BAB1_0859 glutathione S-transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10826 BAW_10826 BAB1_0860 phosphoribosylformylglycinamidinesynthase I catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10827 purS BAB1_0861 phosphoribosylformylglycinamidinesynthase subunit PurS With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide; ATP; and glutamineto formylglycinamidine ribonucleotide; ADP; and glutamate in the fourth step of the purine biosynthetic pathway Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10828 BAW_10828 BAB1_0862 phosphoribosylaminoimidazole-succinocarboxamide synthase catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinatefrom 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10829 BAW_10829 BAB1_0863 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10830 BAW_10830 BAB1_0864 HpcH/HpaI aldolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10831 BAW_10831 BAB1_0865 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10832 BAW_10832 BAB1_0867 glyoxalase/bleomycin resistance protein/dioxygenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10833 purB BAB1_0868 adenylosuccinate lyase Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10834 rpe BAB1_0869 ribulose-phosphate 3-epimerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10835 BAW_10835 BAB1_0870 lipid A biosynthesis lauroyl acyltransferase Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10836 BAW_10836 BAB1_0871 alcohol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10837 BAW_10837 BAB1_0872 3-oxoacyl-(acyl carrier protein) synthase II FabF; beta-Ketoacyl-ACP synthase II; KASII; catalyzes a condensation reaction in fatty acidbiosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10838 BAW_10838 BAB1_0873 3-oxoacyl-(acyl carrier protein) synthase II FabF; beta-ketoacyl-ACP synthase II; KASII; catalyzes a condensation reaction in fatty acidbiosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10839 acpP BAB1_0874 acyl carrier protein Involved in the biosynthetic pathways of fatty acids; phospholipids; lipopolysaccharides; and oligosaccharides Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10840 sagB BAB1_0875 secretion activator protein lysozyme-like protein involved in peptidoglycan degradation for protein secretion Del Giudice et al. 2013. Infect Immun. 81(3):956-64[39]
BAW_10841 galM BAB1_0876 aldose 1-epimerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10842 BAW_10842 BAB1_0877 Pseudogene. Frame shift by presence of a deletion; similar to BMEI1108 (Brucella melitensis 16M) and BS1330_I0854 (Brucella suis 1330); 2-dehydro-3-deoxygluconokinase Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10843 BAW_10843 BAB1_0878 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10844 phnM BAB1_0879 PhnM protein amidohydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10845 BAW_10845 BAB1_0880 HAD family hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10846 BAW_10846 BAB1_0881 amino acid ABC transporter substrate-binding protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10847 BAW_10847 BAB1_0882 tRNA-dihydrouridine synthase A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10848 BAW_10848 BAB1_0883 aspartic protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10849 BAW_10849 BAB1_0884 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10850 cobS BAB1_0885 cobalamin synthase catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10851 cobT BAB1_0886 nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5;6-dimethylbenzimidazole Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10852 BAW_10852 BAB1_0887 AsnC family; transcrptional regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10853 BAW_10853 BAB1_0888 Postponed termination codon, this gene is 30 bp longer as compared to BMEI1097 and BS1330_I0865. Uracil-DNA glycosylase Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10854 BAW_10854 BAB1_0889 Pseudogene. Frame shift; similar to BS1330_I0866 (Brucella suis 1330); Staphylococcus nuclease (SNase-like) Brucella suis 1330 genome; accesion number NC_004310;
BAW_10855 BAW_10855 BAB1_0890 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10856 exoR BAB1_0891 exopolysacchride production negative regulator. Underexpressed in the bvrR mutant Viadas et al. 2010. PLoS One. 5(4): e10216[40]
BAW_10857 xth-1 BAB1_0892 exodexyribonuclease III Hornback and Roop. 2006. J. Bacteriol. 188:1295-1300[41]
BAW_10858 BAW_10858 BAB1_0893 Protein wiyh unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10859 BAW_10859 BAB1_0894 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10860 dgt BAB1_0895 deoxyguanosinetriphosphate triphosphohydrolase-like protein dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10861 argS BAB1_0896 arginyl-tRNA synthetase catalyzes a two-step reaction; first charging an arginine molecule by linking its carboxylgroup to the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10862 apt1 BAB1_0897 Acyl-protein thioesterase 1 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10863 BAW_10863 BAB1_0898 Beta - hexosaminidase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10864 BAW_10864 BAB1_0899 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10865 BAW_10865 BAB1_0900 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10866 tatA BAB1_0901 twin arginine translocase proteinA TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteinswith a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10867 BAW_10867 BAB1_0902 sec-independent translocase mediates the export of protein precursors bearing twin-arginine signal peptides Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10868 tatC BAB1_0903 Sec-independent periplasmic protein translocase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10869 serS BAB1_0904 seryl-tRNA synthetase catalyzes a two-step reaction; first charging a serine molecule by linking its carboxyl group to thealpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10870 surE BAB1_0905 stationary phase survival protein SurE catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10871 pcm BAB1_0906 protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10872 lysM BAB1_0907 peptidoglycan-binding protein LysM Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10873 BAW_10873 BAB1_0908 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10874 BAW_10874 BAB1_0909 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10875 BAW_10875 BAB1_0910 bifunctional preprotein translocase subunit SecD/SecF part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates theproton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms; such as Bacillus subtilis; SecD is fused to SecF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10876 BAW_10876 BAB1_0911 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10877 BAW_10877 BAB1_0912 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10878 BAW_10878 BAB1_0913 tRNA (uracil-5-)-methyltransferaseGid TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10879 BAW_10879 BAB1_0914 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10880 BAW_10880 BAB1_0915 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10881 BAW_10881 BAB1_0916 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10882 tig BAB1_0917 trigger factor Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins;binds ribosomal 50S subunit; forms a homodimer Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10883 gatB BAB1_0918 aspartyl/glutamyl-tRNA amidotransferase subunit B allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidationof misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10884 BAW_10884 BAB1_0919 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10885 BAW_10885 BAB1_0920 NADH dehydrogenase Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone; to the generation of a proton gradient which is then used for ATP synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10886 BAW_10886 BAB1_0921 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10887 BAW_10887 BAB1_0922 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10888 aat BAB1_0923 leucyl/phenylalanyl-tRNA—proteintransferase leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu;Phe;Met; from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10889 accC BAB1_0924 acetyl-CoA carboxylase biotin carboxylase subunit an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase; an enzymethatcatalyzes the formation of malonyl-CoA; which in turn controls the rate of fatty acid metabolism Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10890 accB BAB1_0925 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex;theenzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; which in turn controls the rate of fatty acid metabolism Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10891 aroQ BAB1_0926 3-dehydroquinate dehydratase catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10892 BAW_10892 BAB1_0927 DSBA oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10893 BAW_10893 BAB1_0928 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10894 BAW_10894 BAB1_0929 1-aminocyclopropane-1-carboxylatedeaminase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10895 BAW_10895 BAB1_0930 ribonuclease E and G Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10896 BAW_10896 BAB1_0931 N-acetylmuramoyl-L-alanine amidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10897 BAW_10897 BAB1_0932 penicillin-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10898 BAW_10898 BAB1_0933 peptide chain release factor 2 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10899 BAW_10899 BAB1_0938 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10900 BAW_10900 BAB1_0939 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10901 BAW_10901 BAB1_0940 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10902 bcp BAB1_0941 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10903 BAW_10903 BAB1_0942 RNA recognition domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10904 tyrS BAB1_0943 tyrosyl-tRNA synthetase catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10905 anmK BAB1_0944 anhydro-N-acetylmuramic acid kinase catalyzes hydrolysis of 1;6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10906 qacH BAB1_0945 small multidrug resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10907 BAW_10907 BAB1_0946 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10908 BAW_10908 BAB1_0947 class V aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10909 sufB BAB1_0948 cysteine desulfurase activator complex subunit SufB with SufCD activates cysteine desulfurase SufS Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10910 sufC BAB1_0949 ABC transporter ATPase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10911 BAW_10911 BAB1_0950 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10912 BAW_10912 BAB1_0951 class V aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10913 BAW_10913 BAB1_0952 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10914 BAW_10914 BAB1_0953 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10915 ppnK BAB1_0954 inorganic polyphosphate/ATP-NAD kinase catalyzes the phosphorylation of NAD to NADP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10916 deaD BAB1_0955 ATP-dependent helicase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10917 BAW_10917 BAB1_0956 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10918 BAW_10918 BAB1_0957-0958 Pseudogene. Frame shift and 102 bp deletion; similar to BS1330_I0936 and to BMEI1033; predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10919 BAW_10919 BAB1_0959 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10920 BAW_10920 BAB1_0960 heavy metal transport/detoxification protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10921 BAW_10921 BAB1_0961 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10922 BAW_10922 BAB1_0962 protein-L-isoaspartate(D-aspartate) O-methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10923 BAW_10923 BAB1_0963 Outer membrane efflux protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10924 BAW_10924 BAB1_0964 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10925 valS BAB1_0966 valyl-tRNA synthetase valine—tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10926 BAW_10926 BR0949 Pseudogene. Partial sequence; similar to B. suis 1330 BR0949. In B. suis it is pseudogene due to authentic point mutation. Membrane protein involved in aromatic hydrocarbon degradation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10927 BAW_10927 BAB1_0967 aromatic hydrocarbon degradation protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10928 BAW_10928 BAB1_0968-0969 Pseudogene. Frame shift; similar to BMEI1024 and BS1330_I0946; oxidoreductase Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10929 BAW_10929 BAB1_0970 Pseudogene. Important deletion compared to BS1330_I0951 (aminoacid ABC transporter substrate-binding protein) but postponed termination codon compared to BMEI1022 (arginine/ornithine binding periplasmic protein) Brucella suis 1330 genome; accesion number NC_004310;
BAW_10930 mobB BAB1_0971 rhodopsin-like GPCR superfamily protein Molybdopterin guanine dinucleotide synthesis protein B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10931 mobA BAB1_0972 molybdopterin-guanine dinucleotidebiosynthesis protein A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10932 moaA BAB1_0973 molybdenum cofactor biosynthesis protein A together with moaC; is involved in the conversion of a guanosine derivative (GXP) into molybdopterinprecursor Z Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10933 BAW_10933 BAB1_0974 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10934 BAW_10934 BAB1_0975-0976 Pseudogene. Frame shift; similar to BMEI1017 and BS1330_I0956; FAD-binding monooxygenase Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10935 fumA BAB1_0977 fumarate hidratase A Belongs to the family of class I fumarate hydratases Mignolet et al. 2010. J Bacteriol. 192(12):3235-9[42]
BAW_10936 BAW_10936 BAB1_0978-0979 Pseudogene. Frame shift; similar to BS1330_I0958; predicted protein Brucella suis 1330 genome; accesion number NC_004310;
BAW_10937 BAW_10937 BAB1_0980 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10938 BAW_10938 BAB1_0981 transglycosylase-associated protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10939 BAW_10939 BAB1_0982 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10940 BAW_10940 BAB1_0983 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10941 BAW_10941 BAB1_0984-0985 Pseudogene. Frame shift; similar to BMEI1010; and to BS1330_I0963; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10942 BAW_10942 BAB1_0986 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10943 BAW_10943 BAB1_0987 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10944 BAW_10944 BAB1_0988 Pseudogene. Premature stop codon; similar to BMEI1008 and BS1330_I0966; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10945 BAW_10945 BAB1_0989-0990 Pseudogene. Frame shift; similar to BS1330_I0967; outer membrane protein Omp25b precursor. This protein is expressed in B. melitensis 16M and B. suis 1330. Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53; Sahli et al. 2003. Infect Immun. 71:4326-32; Wagner et al. 2002. Proteomics. 2: 1047-60
BAW_10946 BAW_10946 BAB1_0991 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10947 BAW_10947 BAB1_0992 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10948 BAW_10948 BAB1_0993 Antitoxin for Brnt Heaton et al. 2012. J Biol Chem. 287(15): 12098_12110;
BAW_10949 BAW_10949 BAB1_0994 RNase toxin Heaton et al. 2012. J Biol Chem. 287(15): 12098_12110[43]
BAW_10950 BAW_10950 BAB1_0997 Pseudogene. Premature stop codon; similar to BMEI1000; conserved predicted protein Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10951 BAW_10951 BAB1_0998 Pseudogene. Frame shift; similar to BS1330_I0976; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_10952 BAW_10952 BAB1_0999 glycosyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10953 BAW_10953 BAB1_1000 group 1 glycosyl transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10954 BAW_10954 BAB1_1001 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10955 sagA BAB1_1002 secretion activator protein lysozyme-like protein involved in peptidoglycan degradation for protein secretion Del Giudice et al. 2013. Infect Immun. 81(3):956-64;
BAW_10956 BAW_10956 BAB1_1003 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10957 BAW_10957 BAB1_1004-1005 Pseudogene. Frame shift; similar to BMEI0994 and BS1330_I0982; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_10958 BAW_10958 BAB1_1006 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10959 BAW_10959 BAB1_1007 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10960 BAW_10960 BAB1_1008 arsenate reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10961 rplA BAB1_1009 rare lipoprotein A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10962 BAW_10962 BAB1_1010 D-alanyl-D-alanine carboxypeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10963 BAW_10963 BAB1_1011 thymidylate kinase catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidinemonophosphate (dTMP) to form thymidine diphosphate (dTDP) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10964 BAW_10964 BAB1_1012 DNA polymerase III subunit delta' catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunitseemsto interact with the gamma subunit to transfer the beta subunit on the DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10965 BAW_10965 BAB1_1013 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10966 metG BAB1_1014 methionyl-tRNA synthetase methionine—tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10967 BAW_10967 BAB1_1015 TatD-related deoxyribonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10968 BAW_10968 BAB1_1016 beta-lactamase-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10969 cgt BAB1_1017 cyclic beta-1;2-glucan ABc transporter responsible for transport of beta-1;2-glucans from the cytoplasm to periplasm; inner membrane ABC transporter permease component; Cgt; ChvA; NdvA Roset et al. 2004. Infect Immun. 72(4):2263-71[44]
BAW_10970 BAW_10970 BAB1_1018 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10971 BAW_10971 BAB1_1019 RNA-binding protein S4 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10972 BAW_10972 BAB1_1020 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10973 BAW_10973 BAB1_1021 HAD family hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10974 BAW_10974 BAB1_1022 beta tubulin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10975 glnA BAB1_1023 glutamine synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Kohler et al. 2002. Proc Natl Acad Sci USA. 99(24):15711-6[45]
BAW_10976 glnB BAB1_1024 nitrogen regulatory protein P-II:P-II protein urydylation site Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10977 BAW_10977 BAB1_1025 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10978 BAW_10978 BAB1_1026 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10979 cbbZ BAB1_1027 phosphoglycolate phosphatase catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10980 BAW_10980 BAB1_1028 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10981 BAW_10981 BAB1_1029 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10982 BAW_10982 BAB1_1030 glutathione reductase catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels ofreducedglutathione in the cytosol; involved in redox regulation and oxidative defense Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10983 BAW_10983 BAB1_1031 aminoacyl-tRNA synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10984 BAW_10984 BAB1_1032 diacylglycerol kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10985 nadE BAB1_1033 NAD synthetase NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinicacid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10986 gltX-1 BAB1_1034 glutamyl-tRNA synthetase Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10987 BAW_10987 BAB1_1035 proline-rich extensin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10988 mae BAB1_1036 malic enzyme NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylatesoxaloacetate. A mae 2308 B. abortus mutant is attenuated in the mouse model Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Zuniga-Ripa et al. 2014. J. Bacteriol. 96(16):3045-57
BAW_10989 BAW_10989 BAB1_1037 mandelate racemase/muconate lactonizing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10990 BAW_10990 BAB1_1038 sulfate transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10991 BAW_10991 BAB1_1039 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10992 BAW_10992 BAB1_1040 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10993 BAW_10993 BAB1_1041 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_10994 BAW_10994 BAB1_1042 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10995 BAW_10995 BAB1_1043 BPE043 T4 secreted protein Marchesini et al. 2011. Cell Microbiol. 13(8):1261-74;
BAW_10996 BAW_10996 BAB1_1044 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10997 BAW_10997 BAB1_1045 cytochrome c heme-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_10998 BAW_10998 BAB1_1046 thioredoxin reductase corresponds to BMEI0958 Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_10999 BAW_10999 BAB1_1048 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11000 BAW_11000 BAB1_1049 dihydropteroate synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11001 BAW_11001 BAB1_1050 dihydroneopterin aldolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11002 folK BAB1_1051 7; 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11003 BAW_11003 BAB1_1052 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11004 ftsB BAB1_1053 cell division protein DivIC stabilizes FtsL against RasP cleavage Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11005 BAW_11005 BAB1_1054 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11006 BAW_11006 BAB1_1055 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11007 dksA BAB1_1056 RNA polymerase-binding transcription factor DksA Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11008 BAW_11008 BAB1_1057 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11009 vceC BAB1_1058 VirB type IV secreted effector VirB type IV secreted effector VceC; induce reorganization of ER structures in HeLa cells and induce of proinflamatory host cell responses de Jong et al. 2008. Mol Microbiol. 70(6):1378-96[46]
BAW_11010 BAW_11010 BAB1_1059 histidine kinase/response regulator Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_11011 BAW_11011 BAB1_1060 flavoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11012 BAW_11012 BAB1_1061 beta-lactamase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11013 BAW_11013 BAB1_1062 mechanosensitive (MS) ion channel pseudogenegene in B. ovis ATCC 25840 and in B. suis 1330 Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11014 BAW_11014 BAB1_1063 ribonucleotide-diphosphate reductase subunit alpha Catalyzes the rate-limiting step in dNTP synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11015 BAW_11015 BAB1_1064 site-specific recombinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11016 BAW_11016 BAB1_1065 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11017 BAW_11017 BAB1_1066 xanthine-guanine phosphoribosyltransferase catalyzes the conversion of guanine; xanthine and; to a lesser extent; hypoxanthine to GMP;XMPandIMP; respectively Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11018 BAW_11018 BAB1_1067 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11019 BAW_11019 BAB1_1068 universal stress protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11020 BAW_11020 BAB1_1069 molybdenum cofactor biosynthesis protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11021 wrbA BAB1_1070 TrpR binding protein WrbA stationary phase protein that binds TrpR repressor Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11022 BAW_11022 BAB1_1071 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11023 helD BAB1_1072 ATP-dependent helicase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11024 cysK BAB1_1073 cysteine synthase A CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11025 BAW_11025 BAB1_1074 alanyl-transfer RNA synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11026 BAW_11026 BAB1_1075 thiosulfate sulfurtransferase: rhodanese-like Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11027 BAW_11027 BAB1_1076 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11028 ach1p BAB1_1077 Acetyl-CoA hydrolase/transferase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11029 BAW_11029 BAB1_1078-1079 Pseudogene. Premature stop codon; similar to BMEI0927 and BS1330_I1055; DSBA oxidorreductasa Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11030 BAW_11030 BAB1_1080 Pseudogene. Internal deletion; similar to BS1330_I1056; HlyD family secretion protein Brucella suis 1330 genome; accesion number NC_004310;
BAW_11031 BAW_11031 BAB1_1081-1082 Pseudogene. Frame shift; similar to BMEI0924 and BS1330_I1058; proline dipeptidase PepQ Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11032 BAW_11032 BAB1_1083/BAB1_1084 Pseudogene. Frame shift; similar to BMEI0925 and BS1330_I1057; Zinc-containing alcohol dehydrogenase superfamily Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11033 BAW_11033 BAB1_1085 SAM-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11034 BAW_11034 BAB1_1086 bile acid: sodium symporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11035 BAW_11035 BAB1_1087 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11036 galE-1 BAB1_1088 NAD-dependent epimerase/dehydratase: UDP-glucose 4-epimerase galactose biosynthesis; UDP sugar biosynthesis. In B. melitensis; a galE-1 mutant exhibited intermediate growth patterns in macrophages between those of smooth and rough Brucella strains. The mutant was not sensitive to galactose. Due to altered LPS structure; no or very minimal tissue damage; and protection against virulent B. melitensis challenge; the gal E-1 mutant is considered a vaccine candidate. B. abortus 2308 gal E-1 was able to restore a S. meliloti gal E-1 (exoB) mutant symbiotic phenotype and exopolysaccharide production. Rajashekara et al. 2006. Infect Immun. 74(5):2925-36[47]
BAW_11037 mazG BAB1_1089 nucleoside triphosphate pyrophosphohydrolase functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11038 BAW_11038 BAB1_1090 nitrilotriacetate monooxygenase component B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11039 nitR BAB1_1091 nitroreductase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11040 BAW_11040 BAB1_1092 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11041 thrS BAB1_1093 threonyl-tRNA synthetase catalyzes a two-step reaction; first charging a threonine molecule by linking its carboxylgroup to the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11042 BAW_11042 BAB1_1094 D-alanyl-D-alanine carboxypeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11043 BAW_11043 BAB1_1095 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11044 BAW_11044 BAB1_1096 nitrogen-fixing NifU-like; N-terminal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11045 folE BAB1_1097 GTP cyclohydrolase I involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formateand2-amino-4-hydroxy-6-(erythro-1;2; 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11046 hisI BAB1_1098 phosphoribosyl-AMP cyclohydrolase PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11047 BAW_11047 BAB1_1099 patatin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11048 BAW_11048 BAB1_1100 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11049 BAW_11049 BAB1_1101 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11050 BAW_11050 BAB1_1105 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11051 BAW_11051 BAB1_1106 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11052 BAW_11052 BAB1_1107-1108 Pseudogene. Frame shift; similar to BMEI0903 and BS1330_I0262; L-carnitine dehydratase/bile acid-inducible protein F Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11053 BAW_11053 BAB1_1109 acyl-CoA dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11054 lysR BAB1_1110 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11055 BAW_11055 BAB1_1111 alkane 1-monooxygenase Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11056 BAW_11056 BAB1_1112 acriflavin resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11057 BAW_11057 BAB1_1113 Protein witn unknown function Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11058 BAW_11058 BAB1_1114 transcriptional regulator TetR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11059 BAW_11059 BAB1_0995 Pseudogene. Frame shift; similar to BS1330_I1087 and BMEI1003; queuine tRNA-ribosyltransferase Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11060 queA BAB1_1116 S-adenosylmethionine—tRNA ribosyltransferase-isomerase Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11061 ppiB-2 BAB1_1117 peptidyl-prolyl cis-trans isomerase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11062 ppiB-1 BAB1_1118 peptidyl-prolyl cis-trans isomerase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11063 coaD BAB1_1119 phosphopantetheine adenylyltransferase Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11064 BAW_11064 BAB1_1120 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11065 gyrA BAB1_1121 DNA gyrase subunit A negatively supercoils closed circular double-stranded DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11066 marC BAB1_1122 multiple antibiotic resistance (MarC)-like proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11067 BAW_11067 BAB1_1123 guanylate kinase/L-type calcium channel region Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11068 gntR BAB1_1124 GntR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11069 BAW_11069 BAB1_1125 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11070 ssb BAB1_1126 single-strand binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11071 BAW_11071 BAB1_1127 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618

Genes 1072 to 2098 and RNAs

Locus_tag Gene_synonym Locus_tag in 2308 Product Notes References
BAW_11072 uvrA BAB1_1128 excinuclease ABC subunit A The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPaseand a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB; the uvrA molecules dissociate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11073 BAW_11073 BAB1_1129 histone-like DNA-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11074 lon BAB1_1130 chaperonin ClpA/B; lon protease Robertson et al. 2000. J Bacteriol.182(12):3482-9;
BAW_11075 clpX BAB1_1131 ATP-dependent protease ATP-bindingsubunit ClpX binds and unfolds substrates as part of the ClpXP protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11076 clpP BAB1_1132 ATP-dependent Clp protease proteolytic subunit hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX; ClpP degradesspecificsubstrates Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11077 BAW_11077 BAB1_1133 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11078 hfq BAB1_1134 RNA-binding protein Hfq Stimulates the elongation of poly(A) tails Robertson & Roop. 1999. Mol Microbiol. 34(4):690-700[48]
BAW_11079 BAW_11079 BAB1_1135 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11080 BAW_11080 BAB1_1136 Pseudogene. Premature stop codon; similar to BMEI0870 and BS1330_I1119; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11081 trkA BAB1_1137 potassium transporter peripheral membrane protein involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11082 BAW_11082 BAB1_1138 chaperonin clpA/B response regulator associated to ntrY Carrica et al. 2012. Mol Microbiol. 85(1):39-50;[49]Hallez et al. 2007. EMBO J. 26(5):1444-55[50]
BAW_11083 ntrY BAB1_1139 PAS/histidine kinase/ATPase domain-containing protein Carrica et al. 2012. Mol Microbiol. 85(1):39-50;Hallez et al. 2007. EMBO J. 26(5):1444-55
BAW_11084 ntrC BAB1_1140 response regulator receiver Dorell et al. 1999. Microb Pathog. 27(1):1-11;[51]Hallez et al. 2007. EMBO J. 26(5):1444-55
BAW_11085 BAW_11085 BAB1_1141 ATPase-like ATP-binding protein Dorell et al. 1999. Microb Pathog. 27(1):1-11;Hallez et al. 2007. EMBO J. 26(5):1444-55
BAW_11086 BAW_11086 BAB1_1142 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11087 ispDF BAB1_1143 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2;4-cyclodiphosphate synthase protein bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2;4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11088 BAW_11088 BAB1_1144 CinA; C-terminal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11089 BAW_11089 BAB1_1145 Pseudogene. Frame shift; similar to BS1330_I1118; short chain dehydrogenase Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11090 BAW_11090 BAB1_1146 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11091 lipA BAB1_1147 lipoyl synthase catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP)boundto an octanoyl group to produce a lipoyl group Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11092 BAW_11092 BAB1_1148 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11093 BAW_11093 BAB1_1149 dihydrolipoamide dehydrogenase E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11094 aceF BAB1_1150 branched-chain alpha-keto acid dehydrogenase subunit E2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11095 BAW_11095 BAB1_1151 pyruvate dehydrogenase subunit beta catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1); dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11096 pdhA BAB1_1152 dehydrogenase; E1 component:mitochondrial substrate carrier Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11097 sfi BAB1_1153 septum formation initiator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11098 BAW_11098 BAB1_1154 cytosine-N4-specific DNA-methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11099 eno BAB1_1155 phosphopyruvate hydratase enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11100 kdsA BAB1_1156 2-dehydro-3-deoxyphosphooctonate aldolase catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11101 pyrG BAB1_1157 CTP synthetase CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP toCTPwith either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11102 BAW_11102 BAB1_1158 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11103 BAW_11103 BAB1_1159 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11104 secG BAB1_1160 preprotein translocase subunit SecG Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11105 tpiA BAB1_1161 triosephosphate isomerase Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11106 BAW_11106 BAB1_1162 peptidyl-prolyl cis-trans isomerase D Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11107 trpD BAB1_1163 anthranilate phosphoribosyltransferase Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and5-phospho-alpha-D-ribose 1-diphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11108 trpC BAB1_1164 indole-3-glycerol-phosphate synthase involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11109 moaC BAB1_1165 molybdenum cofactor biosynthesis protein MoaC MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11110 moeA BAB1_1166 molybdenum cofactor biosynthesis protein MoeA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11111 lexA BAB1_1167 LexA repressor Represses a number of genes involved in the response to DNA damage Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11112 BAW_11112 BAB1_1168 ComEC/Rec2-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11113 gltX BAB1_1169 glutamyl-tRNA synthetase Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11114 gltA BAB1_1170 type II citrate synthase type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle; glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11115 lpxB BAB1_1171 lipid-A-disaccharide synthase catalyzes the formation of lipid A disaccharide from UDP-2;3-diacylglucosamine and 2;3-diacylglucosamine-1-phosphate; lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11116 BAW_11116 BAB1_1172 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11117 lpxA BAB1_1173 UDP-N-acetylglucosamine acyltransferase catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid Abiosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11118 fabZ BAB1_1174 (3R)-hydroxymyristoyl-ACP dehydratase in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation;performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11119 lpxD BAB1_1175 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide duringlipidA biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11120 BAW_11120 BAB1_1176 surface antigen also called omp1 or omp89 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11121 BAW_11121 BAB1_1177 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11122 BAW_11122 BAB1_1178 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11123 cdsA BAB1_1179 phosphatidate cytidylyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11124 BAW_11124 BAB1_1180 undecaprenyl pyrophosphate synthase catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11125 frr BAB1_1181 ribosome recycling factor Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translationtermination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11126 pyrH BAB1_1182 uridylate kinase Catalyzes the phosphorylation of UMP to UDP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11127 tsf BAB1_1183 elongation factor Ts EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11128 rpsB BAB1_1184 30S ribosomal protein S2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibitassemblybut results in an inactive subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11129 BAW_11129 BAB1_1185 Pseudogene. Frame shift; similar to BMEI0822 and BS1330_I1159; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11130 BAW_11130 BAB1_1186 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11131 BAW_11131 BAB1_1187 endoribonuclease L-PSP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11132 BAW_11132 BAB1_1188 glycerophosphoryl diester phosphodiesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11133 BAW_11133 BAB1_1189 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11134 BAW_11134 BAB1_1190 histidine triad (HIT) protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11135 clpA BAB1_1191 chaperonin ClpA/B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11136 clpS BAB1_1192 ATP-dependent Clp protease adaptorprotein ClpS involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11137 daaC BAB1_1193 D-alanyl-D-alanine carboxypeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11138 BAW_11138 BAB1_1194 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11139 BAW_11139 BAB1_1195 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11140 BAW_11140 BAB1_1196 Pseudogene. Frame shift; similar to BMEI0811 and BS1330_I1171; L-serine dehydratase; sda Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11141 BAW_11141 BAB1_1198 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11142 BAW_11142 BAB1_1199 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11143 BAW_11143 BAB1_1200 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11144 BAW_11144 BAB1_1201 MerR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11145 BAW_11145 BAB1_1202 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11146 BAW_11146 BAB1_1203-1204 Pseudogene. Frame shift; similar to BS1330_I1177; predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11147 BAW_11147 BAB1_1205 conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11148 BAW_11148 BAB1_1206 7-cyano-7-deazaguanine reductase NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanineinqueuosine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11149 BAW_11149 BAB1_1207 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11150 BAW_11150 BAB1_1208 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11151 BAW_11151 BAB1_1209 helix-hairpin-helix DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11152 BAW_11152 BAB1_1210 carboxyl transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11153 BAW_11153 BAB1_1211 carbamoyl-phosphate synthase subunit L Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11154 bhbA BAB1_1212 methylmalonyl-CoA mutase MDM; functions in conversion of succinate to propionate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11155 BAW_11155 BAB1_1213 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11156 BAW_11156 BAB1_1214 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11157 BAW_11157 BAB1_1215 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11158 BAW_11158 BAB1_1216 tetracycline resistance protein TetB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11159 murI BAB1_1217 glutamate racemase converts L-glutamate to D-glutamate; a component of peptidoglycan Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11160 BAW_11160 BAB1_1218 tRNA/rRNA methyltransferase SpoU Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11161 BAW_11161 BAB1_1219 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11162 BAW_11162 BAB1_1220 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11163 BAW_11163 BAB1_1221 isocitrate dehydrogenase Converts isocitrate to alpha ketoglutarate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11164 BAW_11164 BAB1_1222 alkaline phosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11165 alaS BAB1_1223 alanyl-tRNA synthetase Catalyzes a two-step reaction; first charging an alanyl molecule by linking its carboxyl groupto thealpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11166 recA BAB1_1224 recombinase A catalyzes the hydrolysis of ATP in the presence of single-stranded DNA; the ATP-dependent uptake ofsingle-stranded DNA by duplex DNA; and the ATP-dependent hybridization of homologous single-stranded DNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11167 BAW_11167 BAB1_1225 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11168 BAW_11168 BAB1_1226 outer membrane protein MotY Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11169 BAW_11169 BAB1_1227 transcriptional regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11170 BAW_11170 BAB1_1228 recombination factor protein RarA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11171 BAW_11171 BAB1_1229 serine protease family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11172 rplQ BAB1_1230 50S ribosomal protein L17 is a component of the macrolide binding site in the peptidyl transferase center Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11173 rpoA BAB1_1231 DNA-directed RNA polymerase subunit alpha catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates assubstrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11174 rpsK BAB1_1232 30S ribosomal protein S11 located on the platform of the 30S subunit; it bridges several disparate RNA helices of the16SrRNA;forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11175 rpsM BAB1_1233 30S ribosomal protein S13 located at the top of the head of the 30S subunit; it contacts several helices of the 16S rRNA;makescontact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11176 adk BAB1_1234 adenylate kinase essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11177 secY BAB1_1235 preprotein translocase subunit SecY forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which formsthe channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11178 rplO BAB1_1236 50S ribosomal protein L15 late assembly protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11179 rpmD BAB1_1237 50S ribosomal protein L30 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11180 rpsE BAB1_1238 30S ribosomal protein S5 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11181 rplR BAB1_1239 50S ribosomal protein L18 binds 5S rRNA along with protein L5 and L25 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11182 rplF BAB1_1240 50S ribosomal protein L6 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as basedonstructural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11183 rpsH BAB1_1241 30S ribosomal protein S8 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform ofthe30S subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11184 rpsN BAB1_1242 30S ribosomal protein S14 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similarto what is observed with proteins L31 and L33; some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome; then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11185 rplE BAB1_1243 50S ribosomal protein L5 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridgeto the 30Ssubunit in the ribosome by binding to S13 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11186 rplX BAB1_1244 50S ribosomal protein L24 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S;surroundspolypeptide exit tunnel Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11187 rplN BAB1_1245 50S ribosomal protein L14 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11188 rpsQ BAB1_1246 30S ribosomal protein S17 primary binding protein; helps mediate assembly; involved in translation fidelity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11189 rpmC BAB1_1247 50S ribosomal protein L29 one of the stabilizing components for the large ribosomal subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11190 rplP BAB1_1248 50S ribosomal protein L16 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11191 rpsC BAB1_1249 30S ribosomal protein S3 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNAinthecomplete ribosome to position it for translation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11192 rplV BAB1_1250 50S ribosomal protein L22 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact withall6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11193 rpsS BAB1_1251 30S ribosomal protein S19 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11194 rplB BAB1_1252 50S ribosomal protein L2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunitsto form the 70S ribosome; for tRNA binding and peptide bond formation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11195 rplW BAB1_1253 50S ribosomal protein L23 binds third domain of 23S rRNA and protein L29; part of exit tunnel Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11196 rplD BAB1_1254 50S ribosomal protein L4 L4 is important during the early stages of 50S assembly; it initially binds near the 5' endofthe23S rRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11197 rplC BAB1_1255 50S ribosomal protein L3 binds directly near the 3' end of the 23S rRNA; where it nucleates assembly of the 50S subunit;essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11198 rpsJ BAB1_1256 30S ribosomal protein S10 NusE; involved in assembly of the 30S subunit; in the ribosome; this protein is involved inthebinding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11199 fusA BAB1_1258 elongation factor G EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms havemultiple copies of this gene Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11200 rpsG BAB1_1259 30S ribosomal protein S7 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11201 rpsL BAB1_1260 30S ribosomal protein S12 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection intheA siteand with the mRNA backbone; located at the interface of the 30S and 50S subunits; it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11202 BAW_11202 BAB1_1261 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11203 BAW_11203 BAB1_1262 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11204 rpoC BAB1_1263 DNA-directed RNA polymerase subunit beta' DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11205 rpoB BAB1_1264 DNA-directed RNA polymerase subunit beta DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11206 rplL BAB1_1265 50S ribosomal protein L7/L12 present in two forms; L12 is normal; while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11207 rplJ BAB1_1266 50S ribosomal protein L10 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11208 rplA BAB1_1267 50S ribosomal protein L1 in Escherichia coli and Methanococcus; this protein autoregulates expression; the binding sitein themRNA mimics the binding site in the 23S rRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11209 rplK BAB1_1268 50S ribosomal protein L11 binds directly to 23S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11210 nusG BAB1_1269 transcription antitermination protein NusG Modulates Rho-dependent transcription termination Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11211 secE BAB1_1270 preprotein translocase subunit SecE forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to whichsecAbinds and translocates targeted polypeptides across the cytoplasmic membrane; a process driven by ATP and a proton-motive force Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11212 tuf-2 BAB1_1257 elongation factor Tu EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon; GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11213 BAW_11213 BAB1_1271 elongation factor Tu EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon; GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11214 BAW_11214 BAB1_1272 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11215 BAW_11215 BAB1_1274 inosine-5-monophosphate dehydrogenase CBS containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11216 BAW_11216 BAB1_1275 BPE275 Rhomboid protease Marchesini et al. 2011. Cell Microbiol. 13(8):1261-74;
BAW_11217 BAW_11217 BAB1_1276 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11218 mopJ BAB1_1277 PdhS-interacting protein partially polar when fused to YFP Mignolet et al. 2010. J Bacteriol. 192(12):3235-9;
BAW_11219 BAW_11219 BAB1_1278 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11220 BAW_11220 BAB1_1279 acetyltransferase family effector interacting with Rab2 de Barsy et al. 2011. Cell Microbiol. 13(7):1044-58[52]
BAW_11221 BAW_11221 BAB1_1280 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11222 BAW_11222 BAB1_1281 serine O-acetyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11223 BAW_11223 BAB1_1282 alpha/beta fold hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11224 BAW_11224 BAB1_1283 Protein with unknown function DUF192 domain containing protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11225 BAW_11225 BAB1_1284 cold shock DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11226 BAW_11226 BAB1_1285 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11227 gloA BAB1_1286 lactoylglutathione lyase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11228 BAW_11228 BAB1_1287-1288-1289 Pseudogene. Double frame shift; similar to BMEI0729 and BS1330_I1265; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11229 recJ BAB1_1290 single-stranded-DNA-specific exonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11230 ddl BAB1_1291 D-alanyl-alanine synthetase A D-alanine—D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11231 glpX BAB1_1292 fructose 1;6-bisphosphatase II type II fructose 1;6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Zuniga-Ripa et al. 2014. J. Bacteriol. 96(16):3045-57
BAW_11232 BAW_11232 BAB1_1293 homoserine dehydrogenase catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11233 BAW_11233 BAB1_1294 aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11234 BAW_11234 BAB1_1295 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11235 BAW_11235 BAB1_1296 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11236 BAW_11236 BAB1_1297 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11237 BAW_11237 BAB1_1298 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11238 sfsA BAB1_1299 sugar fermentation stimulation protein A Regulatory factor involved in maltose metabolism Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11239 map BAB1_1300 methionine aminopeptidase catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II)however activity has been shown for some methionine aminopeptidases with Zn; Fe; or Mn Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11240 radC BAB1_1301 DNA repair protein RadC Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementarysingle-stranded DNA and by simulation of RAD51 recombinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11241 BAW_11241 BAB1_1302 Outer membrane protein Omp22 precursor Member of the group 3 of outer membrane proteins. Contains a common site of signal peptide cleavage (AXAAD). Its function is unknown. Similar to B. suis 1330 BS1330_I1280 and B. melitensis 16M BME_RS03560. Lamontagne et al. 2010. BMC Genomics. 11:300; Guzmán-Verri et al. 2002. Proc Natl Acad Sci USA. 99: 12375-80; Sahli et al. 2003. Infect Immun. 71:4326-32; Manterola et al.2007. Infect Immun. 75: 4867-74
BAW_11242 BAW_11242 BAB1_1303 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11243 BAW_11243 BAB1_1304 nitrite/sulfite reductase ferredoxin subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11244 cobH BAB1_1305 precorrin-8X methylmutase catalyzes the interconversion of precorrin-8X and hydrogenobyrinate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11245 cobI BAB1_1306 precorrin-2 C(20)-methyltransferase catalyzes the formation of precorrin-3 from precorrin-2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11246 BAW_11246 BAB1_1307 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11247 BAW_11247 BAB1_1308 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11248 BAW_11248 BAB1_1309-1310 Pseudogene. Double frame shift; similar to BS1330_I1287; phospholipase/carboxylesterase family protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11249 BAW_11249 BAB1_1311-1312 Pseudogene. Premature stop codon and frame shift; similar to BS1330_I1288; monooxygenase Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11250 BAW_11250 BAB1_1313 Leu/Ile/Val-binding family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11251 cobD BAB1_1314 cobalamin biosynthesis protein CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanolon theF carboxylic group Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11252 cobC BAB1_1315 class I and II aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11253 BAW_11253 BAB1_1316 cobyrinic acid a;c-diamide synthase responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid orhydrogenobrynic acid Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11254 BAW_11254 BAB1_1317 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11255 cbiD BAB1_1318 cobalt-precorrin-6A synthase Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acidfrom the resulting intermediate to form cobalt-precorrin-6A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11256 cobK BAB1_1319 cobalt-precorrin-6x reductase CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production; one aerobic (ex. P.denitrificans); the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11257 BAW_11257 BAB1_1320 uroporphyrin-III C/tetrapyrrole methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11258 BAW_11258 BAB1_1321 antifreeze protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11259 BAW_11259 BAB1_1322 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11260 BAW_11260 BAB1_1323 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11261 BAW_11261 BAB1_1324 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11262 cobO BAB1_1325 cob(I)yrinic acid a;c-diamide adenosyltransferase catalyzes the formation of adenosylcob(III)yrinic acid a;c-diamide from cob(I)yrinic acid a;c-diamide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11263 cobN BAB1_1326 cobaltochelatase subunit CobN Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11264 BAW_11264 BAB1_1327 cobalamin synthesis protein P47K Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11265 cobU BAB1_1328 adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphateand the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11266 BAW_11266 BAB1_1329 Pseudogene. Frame shift; similar to BMEI0692 and BS1330_I1305; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11267 BAW_11267 BAB1_1330 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11268 BAW_11268 BAB1_1331 cobyric acid synthase catalyzes amidations at positions B; D; E; and G on adenosylcobyrinic A;C-diamide. NH(2) groupsareprovided by glutamine; and one molecule of ATP is hydrogenolyzed for each amidation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11269 BAW_11269 BAB1_1332 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11270 BAW_11270 BAB1_1333 acyl-CoA dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11271 BAW_11271 BAB1_1334 3-hydroxyisobutyrate dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11272 BAW_11272 BAB1_1335 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11273 BAW_11273 BAB1_1336 Entericidin EcnAB Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11274 BAW_11274 BAB1_1337 transcriptional regulator LysR Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11275 BAW_11275 BAB1_1338 AraC family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11276 BAW_11276 BAB1_1339 Pseudogene. Premature stop codon; similar to BMEI0684; sarcosine dehydrogenase Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11277 BAW_11277 BAB1_1341 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11278 BAW_11278 BAB1_1342 mechanosensitive (MS) ion channel pseudogene in B. ovis and in B. suis 1330 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11279 BAW_11279 BAB1_1343 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11280 BAW_11280 BAB1_1344 bifunctional preprotein translocase subunit SecD/SecF part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates theproton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms; such as Bacillus subtilis; SecD is fused to SecF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11281 BAW_11281 BAB1_1345 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11282 BAW_11282 BAB1_1346 low PH-induced protein A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11283 BAW_11283 BAB1_1347 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11284 BAW_11284 BAB1_1348 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11285 BAW_11285 BAB1_1349 sulfate ABC transporter permease protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11286 BAW_11286 BAB1_1350 sulfate/thiosulfate transporter subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11287 BAW_11287 BAB1_1351 sulfate-/thiosulfate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11288 BAW_11288 BAB1_1352 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11289 BAW_11289 BAB1_1353 CBS/transport-associated domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11290 BAW_11290 BAB1_1354 DedA family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11291 BAW_11291 BAB1_1355 calcium-binding EF-hand Lin & Ficht. 1995. Infect Immun. 63(4):1409-14[53]
BAW_11292 fucU BAB1_1356 transport protein RbsD/FucU Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11293 BAW_11293 BAB1_1357 short chain dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11294 BAW_11294 BAB1_1358 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11295 BAW_11295 BAB1_1359-1360 Pseudogene. Frame shift; similar to BMEI0664 and BS1330_I1335; sugar ABC transporter; permease protein Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11296 BAW_11296 BAB1_1361 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11297 BAW_11297 BAB1_1362 LacI transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11298 BAW_11298 BAB1_1363 oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11299 BAW_11299 BAB1_1364 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11300 BAW_11300 BAB1_1365 sodium:dicarboxylate symporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11301 BAW_11301 BAB1_1366 periplasmic binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11302 BAW_11302 BAB1_1367 TonB-dependent receptor protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11303 BAW_11303 BAB1_1368 ABC transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11304 BAW_11304 BAB1_1369-1370 Pseudogene. Frame shift; similar to BS1330_I1345; ABC transporter ATP-binding protein/permease Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11305 BAW_11305 BAB1_1371 RTX secretion protein D Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11306 BAW_11306 BAB1_1372 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11307 BAW_11307 BAB1_1373 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11308 BAW_11308 BAB1_1374 glycoside hydrolase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11309 BAW_11309 BAB1_1375 Protein with unknown function Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11310 ureA BAB1_1376 urease subunit gamma UreA; with UreB and UreC; catalyzes the hydrolysis of urea to ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD; UreE; UreF; and UreG are necessary for assembly of the metallocenter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11311 ureB BAB1_1377 urease subunit beta ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pyloriandYersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) does not seem to be involved with urease activity; optimum growth; resistance to low-pH killing in-vitro and persistence in-vivo Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11312 ureC BAB1_1378 urease subunit alpha ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Yersinia enterocoliticathe ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11313 BAW_11313 BAB1_1379 Pseudogene. Double frame shift; similar to BMEI0646 and BS1330_I1354; urease accessory protein UreE Brucella suis 1330 genome; accesion number NC_004310;Brucella melitensis 16M accession number NC_003317
BAW_11314 BAW_11314 BAB1_1380 urease accessory protein UreF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11315 BAW_11315 BAB1_1381 urease accessory protein UreG Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11316 ureD-2 BAB1_1382 urease accessory protein UreD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11317 BAW_11317 BAB1_1383 Urea transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11318 BAW_11318 BAB1_1384 nickel transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11319 BAW_11319 BAB1_1385 nickel transport Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11320 BAW_11320 BAB1_1386 nickel transport Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11321 BAW_11321 BAB1_1387 nickel transport Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11322 BAW_11322 BAB1_1388 nickel transport Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11323 ccrB BAB1_1389 camphor resistance protein CrcB may be involved in chromosome condensation; overexpression in Escherichia coli protects againstdecondensation by camphor; overexpressing the protein results in an increase in supercoiling Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11324 crcB BAB1_1390 camphor resistance CrcB protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11325 BAW_11325 BAB1_1391 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11326 BAW_11326 BAB1_1392 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11327 BAW_11327 BAB1_1393 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11328 BAW_11328 BAB1_1394 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11329 BAW_11329 BAB1_1395 endonuclease/exonuclease/phosphatase family protein pseudogene in B.ovis and in B. suis 1330 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11330 BAW_11330 BAB1_1396 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11331 BAW_11331 BAB1_1397 class I and II aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11332 BAW_11332 BAB1_1398 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11333 BAW_11333 BAB1_1399 ketol-acid reductoisomerase catalyzes the formation of (R)-2;3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11334 BAW_11334 BAB1_1400 transcriptional regulator TetR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11335 BAW_11335 BAB1_1401 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11336 BAW_11336 BAB1_1402 K+ potassium transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11337 BAW_11337 BAB1_1403 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11338 BAW_11338 BAB1_1404 pyridoxine 5'-phosphate synthase involved in the de novo synthesis of pyridoxine (Vitamin B6) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11339 BAW_11339 BAB1_1405 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11340 BAW_11340 BAB1_1406 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11341 ilvH BAB1_1407 acetolactate synthase 3 regulatorysubunit with IlvI catalyzes the formation of 2-acetolactate from pyruvate; the small subunit is required forfull activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates; valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11342 ilvB BAB1_1408 acetolactate synthase 3 catalyticsubunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11343 miaA BAB1_1409 tRNA delta(2)-isopentenylpyrophosphate transferase IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia colithis enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11344 BAW_11344 BAB1_1410 phosphoserine phosphatase SerB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11345 BAW_11345 BAB1_1411 NAD(FAD)-utilizing dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11346 BAW_11346 BAB1_1412 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11347 BAW_11347 BAB1_1413 serine protease family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11348 BAW_11348 BAB1_1414 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11349 hflC BAB1_1415 Band 7 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11350 BAW_11350 BAB1_1416 Protein with unknown function HflK putative conserved domains Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11351 folA BAB1_1417 dihydrofolate reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11352 thyA BAB1_1418 thymidylate synthase ThyA; catalyzes formation of dTMP and 7;8-dihydrofolate from 5;10-methylenetetrahydrofolateanddUMP;involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli; one of which appears to be phage-derived Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11353 BAW_11353 BAB1_1419 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11354 BAW_11354 BAB1_1420 Bcr/CflA subfamily drug resistancetransporter B suis mutant is attenuated at 48h macrophage postinfection (Kohler S et al. 2002); sugar porin Kohler et al. 2002. Proc Natl Acad Sci U S A. 99(24):15711-6;
BAW_11355 BAW_11355 BAB1_1421 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11356 BAW_11356 BAB1_1422 transcriptional regulator TetR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11357 BAW_11357 BAB1_1423 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11358 BAW_11358 BAB1_1424 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11359 BAW_11359 BAB1_1425 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11360 BAW_11360 BAB1_1426 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11361 BAW_11361 BAB1_1427 alpha-isopropylmalate/homocitratesynthase AsmA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11362 BAW_11362 BAB1_1428 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11363 BAW_11363 BAB1_1429 FAD linked oxidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11364 BAW_11364 BAB1_1430 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11365 BAW_11365 BAB1_1431 serine/threonine protein kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11366 BAW_11366 BAB1_1432 UvrD/REP helicase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11367 BAW_11367 BAB1_1433 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11368 BAW_11368 BAB1_1434 hexapeptide repeat-containing transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11369 BAW_11369 BAB1_1435 electron transport protein SCO1/SenC Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11370 prmA BAB1_1436 50S ribosomal protein L11 methyltransferase methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genesinEscherichia coli or Thermus thermophilus has no apparent phenotype Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11371 BAW_11371 BAB1_1437 M24 family metallopeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11372 BAW_11372 BAB1_1438 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11373 ligA BAB1_1439 NAD-dependent DNA ligase LigA this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxylgroups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11374 recN BAB1_1440 DNA repair protein RecN Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11375 BAW_11375 BAB1_1441 Outer membrane protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11376 BAW_11376 BAB1_1442 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11377 lpxC BAB1_1443 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11378 ftsZ BAB1_1444 cell division protein FtsZ /product=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11379 ftsA BAB1_1445 heat shock protein Hsp70 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11380 BAW_11380 BAB1_1446 cell division protein FtsQ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11381 ddl BAB1_1447 D-alanine—D-alanine ligase D-alanine—D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11382 murB BAB1_1448 UDP-N-acetylenolpyruvoylglucosamine reductase catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate inpeptidoglycan biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11383 murC BAB1_1449 UDP-N-acetylmuramate—L-alanine ligase Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine inpeptidoglycan synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11384 murG BAB1_1450 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase UDP-N-acetylglucosamine—N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11385 ftsW BAB1_1451 cell cycle protein phosphopantetheine attachment site Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11386 murD BAB1_1452 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase UDP-N-acetylmuramoylalanine—D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic;catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11387 mraY BAB1_1453 phospho-N-acetylmuramoyl-pentapeptide- transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11388 BAW_11388 BAB1_1454 cytoplasmic peptidoglycan synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11389 murE BAB1_1455 UDP-N-acetylmuramoylalanyl-D-glutamate—2; 6-diaminopimelate ligase involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes theadditionof meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11390 BAW_11390 BAB1_1456 penicillin-binding protein 2/3 family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11391 BAW_11391 BAB1_1457 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11392 rsmH BAB1_1458 S-adenosyl-methyltransferase MraW Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11393 BAW_11393 BAB1_1459 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11394 mntH BAB1_1460 manganese transport protein MntH Anderson et al. 2009. Infect Immun. 77(8):3466-74[54]
BAW_11395 rnpB BAB1_2215 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11396 BAW_11396 BAB1_1461 SLT domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11397 BAW_11397 BAB1_1462 peptidoglycan binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11398 BAW_11398 BAB1_1463 heat shock protein DnaJ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11399 BAW_11399 BAB1_1464 antifreeze protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11400 BAW_11400 BAB1_1465 glycoside hydrolase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11401 BAW_11401 BAB1_1466 putative transglycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11402 BAW_11402 BAB1_1467 auxin efflux carrier Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11403 metF BAB1_1468 5;10-methylenetetrahydrofolate reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11404 BAW_11404 BAB1_1469 Transcriptional regulator; ArsR family Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11405 BAW_11405 BAB1_1470 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11406 BAW_11406 BAB1_1471 major facilitator superfamily sugar transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11407 BAW_11407 BAB1_1472 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11408 BAW_11408 BAB1_1473 trans-aconitate 2-methyltransferase catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine fromS-adenosyl-L-methionine and trans-aconitate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11409 BAW_11409 BAB1_1474 putative ABC transporter ATP-binding protein ChvD; in Agrobacterium tumefaciens; mutations in both Walker boxes were found to affect virulence Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11410 BAW_11410 BAB1_1475 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11411 BAW_11411 BAB1_1476 esterase/lipase/thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11412 BAW_11412 BAB1_1477-1478 Pseudogene. Frame shift; similar to BS1330_I1453; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11413 BAW_11413 BAB1_1479-1480 Pseudogene. Frame shift; similar to BS1330_I1454; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11414 BAW_11414 BAB1_1481 ring hydroxylating dioxygenase subunit alpha Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11415 BAW_11415 BAB1_1482 phthalate dioxygenase reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11416 BAW_11416 BAB1_1483 PhnA protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11417 BAW_11417 BAB1_1484 isochorismatase hydrolase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11418 BAW_11418 BAB1_1485 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11419 BAW_11419 BAB1_1486 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11420 BAW_11420 BAB1_1487 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11421 BAW_11421 BAB1_1488 choloylglycine hydrolase CGH confers the ability to resist the antimicrobial action of bile salts and contribute to the ability of Brucella to infect the host through the oral route Delpino et al. 2007. Infect Immun. 75(1):299-305[55]
BAW_11422 BAW_11422 BAB1_1489 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11423 BAW_11423 BAB1_1490 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11424 BAW_11424 BAB1_1491 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11425 sepA BAB1_1492 VirB type IV secreted effector Only present in Brucella spp. And has no detectable homology to known proteins. Mutant was more invasive in professional and non-professional cells than the wild type; but it has a defect in excluding the lysosomal marker Lamp-1 and was inactivated more efficeiently during the early phases of the intracellular life cycle. Dohmer et al. 2014. Cell Microbiol. 16(3):396-410[56]
BAW_11426 BAW_11426 BAB1_1493 phage integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11427 omp28 BAB1_1494 immunoreactive 28 kDa outer membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11428 BAW_11428 BAB1_1495 antifreeze protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11429 BAW_11429 BAB1_1496 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11430 BAW_11430 BAB1_1497 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11431 rpoD BAB1_1498 RNA polymerase sigma factor RpoD sigma factors are initiation factors that promote the attachment of RNA polymerase to specificinitiation sites and are then released; this is the primary sigma factor of bacteria Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11432 dnaG BAB1_1499 DNA primase synthesizes RNA primers at the replication forks Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11433 BAW_11433 BAB1_1500 Na+/Pi-cotransporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11434 BAW_11434 BAB1_1501 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11435 BAW_11435 BAB1_1502 carbamoyl phosphate synthase smallsubunit catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and argininebiosynthesis pathways; forms an octamer composed of four CarAB dimers Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11436 BAW_11436 BAB1_1503 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11437 BAW_11437 BAB1_1504 neutral zinc metallopeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11438 BAW_11438 BAB1_1505 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11439 BAW_11439 BAB1_1506-1507 Pseudogene. Frame shift; similar to BS1330_I1481; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11440 carB BAB1_1508 carbamoyl phosphate synthase largesubunit four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes theproduction of carbamoyl phosphate; CarB is responsible for the amidotransferase activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11441 BAW_11441 BAB1_1509 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11442 BAW_11442 BAB1_1510 ABC transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11443 BAW_11443 BAB1_1511 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11444 BAW_11444 BAB1_1512 cold shock DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11445 BAW_11445 BAB1_1513 glutathione S-transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11446 aspC BAB1_1514 aspartate aminotransferase catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11447 BAW_11447 BAB1_1515 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11448 BAW_11448 BAB1_1516 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11449 vtlR BAB1_1517 transcriptional regulator LysR type Sheehan et al. 2015. J. Bacteriol. 197(9):1582-91;
BAW_11450 trxB BAB1_1518 pyridine nucleotide-disulfide oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11451 BAW_11451 BAB1_1519 cation transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11452 BAW_11452 BAB1_1520 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11453 lrp-1 BAB1_1521 AsnC family regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11454 wadC BAB1_1522 group 1 glycosyl transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11455 greA BAB1_1523 transcription elongation factor GreA necessary for efficient RNA polymerase transcription elongation past template-encoded arrestingsites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through; resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11456 BAW_11456 BAB1_1524 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11457 BAW_11457 BAB1_1525 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11458 BAW_11458 BAB1_1526 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11459 BAW_11459 BAB1_1527 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11460 BAW_11460 BAB1_1528 thioesterase superfamily protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11461 BAW_11461 BAB1_1529 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11462 uvrB BAB1_1530 excinuclease ABC subunit B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpinofthe Uvr-B subunit is inserted between the strands; where it probes for the presence of a lesion Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11463 BAW_11463 BAB1_1531 SLT domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11464 BAW_11464 BAB1_1532 cold shock DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11465 BAW_11465 BAB1_1533 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11466 BAW_11466 BAB1_1534 beta-lactamase-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11467 BAW_11467 BAB1_1535 C-5 cytosine-specific DNA methylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11468 BAW_11468 BAB1_1536 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11469 BAW_11469 BAB1_1537 MarR family regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11470 BAW_11470 BAB1_1538 response regulator receiver Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_11471 BAW_11471 BAB1_1539 histidine kinase Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_11472 BAW_11472 BAB1_1540 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11473 csaA BAB1_1541 t-RNA-binding region Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11474 BAW_11474 BAB1_1542 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11475 BAW_11475 BAB1_1543 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11476 lgt BAB1_1544 prolipoprotein diacylglyceryl transferase transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11477 BAW_11477 BAB1_1545 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11478 BAW_11478 BAB1_1546 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11479 BAW_11479 BAB1_1547 M24 family metallopeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11480 BAW_11480 BAB1_1548 putative lipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11481 BAW_11481 BAB1_1549 ribose-phosphate pyrophosphokinase catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11482 BAW_11482 BAB1_1550 ATP/GTP-binding domain-containingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11483 BAW_11483 BAB1_1551 50S ribosomal protein L25/generalstress protein Ctc the Ctc family of proteins consists of two types; one that contains the N-terminal ribosomal proteinL25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response Danese et al. 2004. Infect Immun. 72(10):5783-90[57]
BAW_11484 pth BAB1_1552 peptidyl-tRNA hydrolase Enables the recycling of peptidyl-tRNAs produced at termination of translation Danese et al. 2004. Infect Immun. 72(10):5783-90;
BAW_11485 BAW_11485 BAB1_1553 GTP-dependent nucleic acid-bindingprotein EngD translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF proteinshowed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11486 BAW_11486 BAB1_1554 MaoC-like dehydratase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11487 BAW_11487 BAB1_1555 MaoC-like dehydratase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11488 apt BAB1_1556 adenine phosphoribosyltransferase catalyzes a salvage reaction resulting in the formation of AMP which is metabolically lesscostly than a de novo synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11489 BAW_11489 BAB1_1557 cytochrome c heme-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11490 petB BAB1_1558 cytochrome b/b6; N-terminal:cytochrome b/b6; C-terminal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11491 BAW_11491 BAB1_1559 Rieske iron-sulfur domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11492 BAW_11492 BAB1_1560 uridine kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11493 BAW_11493 BAB1_1561 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11494 BAW_11494 BAB1_1562 tRNA/rRNA methyltransferase SpoU Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11495 BAW_11495 BAB1_1563 purine nucleoside permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11496 BAW_11496 BAB1_1564 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11497 BAW_11497 BAB1_1565 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11498 hemF BAB1_1566 coproporphyrinogen III oxidase catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups duringhemesynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11499 BAW_11499 BAB1_1567 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11500 BAW_11500 BAB1_1568 aspartyl/asparaginyl beta-hydroxylase corresponds to BMEI0465 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11501 BAW_11501 BAB1_1569 lipid A-myristate beta-hydroxylase no differences found for consider it a pseudogene; corresponds to BMEI0464 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11502 BAW_11502 BAB1_1570 polynucleotide adenylyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11503 BAW_11503 BAB1_1571 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11504 BAW_11504 BAB1_1572 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11505 BAW_11505 BAB1_1573 chaperonin ClpA/B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11506 BAW_11506 BAB1_1574 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11507 BAW_11507 BAB1_1575 blue (type 1) copper domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11508 BAW_11508 BAB1_1576 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11509 BAW_11509 BAB1_1577 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11510 BAW_11510 BAB1_1578 glutathione S-transferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11511 BAW_11511 BAB1_1579 OmpW family outer membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11512 BAW_11512 BAB1_1580 NUDIX hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11513 BAW_11513 BAB1_1581 metallo-phosphoesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11514 BAW_11514 BAB1_1582 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11515 leuA BAB1_1583 2-isopropylmalate synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11516 BAW_11516 BAB1_1584 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11517 BAW_11517 BAB1_1586 anthranilate synthase trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11518 lrp-2 BAB1_1587 transcriptional regulator LysR Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11519 BAW_11519 BAB1_1588 MarR family regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11520 BAW_11520 BAB1_1589 major facilitator transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11521 BAW_11521 BAB1_1590 methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11522 BAW_11522 BAB1_1591 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11523 BAW_11523 BAB1_1592 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11524 choX BAB1_1593 High affinity choline uptake periplasmic component Herrmann et al. 2013. J Bacteriol. 95(3):493-501[58]
BAW_11525 BAW_11525 BAB1_1594 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11526 BAW_11526 BAB1_1595 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11527 BAW_11527 BAB1_1596 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11528 BAW_11528 BAB1_1597 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11529 BAW_11529 BAB1_1598 sodium:dicarboxylate symporter inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11530 BAW_11530 BAB1_1599 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11531 BAW_11531 BAB1_1600 periplasmic dipeptide transport protein pseudogene in B. suis 1330 Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11532 BAW_11532 BAB1_1601-1602 Pseudogene. Premature stop codon; similar to BMEI0433; periplasmic dipeptide transport protein precursor Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11533 BAW_11533 BAB1_1603 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11534 BAW_11534 BAB1_1604 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11535 BAW_11535 BAB1_1605 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86
BAW_11536 BAW_11536 BAB1_1606 tRNA/rRNA methyltransferase SpoU Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11537 mnmA BAB1_1607 tRNA-specific 2-thiouridylase MnmA catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11538 BAW_11538 BAB1_1608 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11539 BAW_11539 BAB1_1609 Protein with unknown function Gora et al. 2010. Mol Cell.13;39(3):455-67[59]
BAW_11540 BAW_11540 BAB1_1610 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11541 BAW_11541 BAB1_1611 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11542 BAW_11542 BAB1_1612 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11543 BAW_11543 BAB1_1613 putative phosphotransferase of CtrA Biondi et al. 2006. Nature. 444(7121):899-904[60]
BAW_11544 ctrA BAB1_1614 response regulator receiver Bellefontaine et al. 2002. Mol Microbiol. 43(4):945-60[61]
BAW_11545 BAW_11545 BAB1_1615 Protein with unknown function Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11546 BAW_11546 BAB1_1616 DegT/DnrJ/EryC1/StrS aminotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11547 BAW_11547 BAB1_1617 oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11548 BAW_11548 BAB1_1618 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11549 BAW_11549 BAB1_1619 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11550 BAW_11550 BAB1_1620 glycosyl transferase family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11551 BAW_11551 BAB1_1621 PAS/histidine kinase/ATPase domain-containing protein Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_11552 BAW_11552 BAB1_1622 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11553 BAW_11553 BAB1_1623 AsmA protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11554 BAW_11554 BAB1_1624 binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11555 BAW_11555 BAB1_1625-1626 Pseudogene. Frame shif; similar to BMEI0413; binding-protein-dependent transport systems inner membrane component Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11556 BAW_11556 BAB1_1627 spermidine/putrescine ABC transporter ATP-binding subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11557 BAW_11557 BAB1_1628 solute-binding family 1 protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11558 BAW_11558 BAB1_1629-1630 Pseudogene. Premature stop codon; similar to BS1330_I1607; transcriptional regulator Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11559 aceA BAB1_1631 isocitrate lyase and phosphorylmutase:isocitrate lyase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Zuniga-Ripa et al. 2014. J. Bacteriol. 96(16):3045-57
BAW_11560 BAW_11560 BAB1_1632 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11561 BAW_11561 BAB1_1633 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11562 BAW_11562 BAB1_1634 7-alpha-hydroxysteroid dehydrogenase Acts on the hydroxyl group at position 7 of the steroid frame Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11563 BAW_11563 BAB1_1635 short-chain dehydrogenase/reductase SDR:glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11564 BAW_11564 BAB1_1636-1937 Pseudogene. Premature stop codon; similar to BS1330_I1614; conserved domain protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11565 BAW_11565 BAB1_1638 Delayed-early response protein/equilibrative nucleoside transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11566 omp31b BAB1_1639 outer membrane protein Omp31b precursor similar to BMEI 0402; outer membrane protein Omp31b precursor. This protein is expressed in B. suis 1330. Member of the group 3 of outer membrane proteins. Contains a common site of signal peptide cleavage (AXAAD). Its function is unknown. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618; Sahli et al. 2003. Infect Immun. 71:4326-32
BAW_11567 BAW_11567 BAB1_1640 patatin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11568 BAW_11568 BAB1_1641 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11569 BAW_11569 BAB1_1642 dihydroxyacetona kinase Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11570 BAW_11570 BAB1_1643-1644 Pseudogene. Frame shift; similar to BMEI0398; dihydroxyacetone kinase Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11571 BAW_11571 BAB1_1645 Dak phosphatase domain Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11572 BAW_11572 BAB1_1646 Dak kinase domain Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11573 omp31b BAB1_1647 short chain dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11574 BAW_11574 BAB1_1648 periplasmic binding protein/LacI transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11575 rbsC-2 BAB1_1649 inner-membrane translocator:voltage-dependent potassium channel Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11576 rbsA-2 BAB1_1650 Ribose import ATP-binding proteinrbsA-2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11577 vceA BAB1_1652 VirB type IV secreted effector conserved protein among Brucella. Its expression is co-regulated with VirB via Vjbr in Brucella abortus 2308 de Jong et al. 2008. Mol Microbiol. 70(6):1378-96;Brucella abortus 2308; accesion number NC_007618
BAW_11578 BAW_11578 BAB1_1653 choline dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11579 iclR3 BAB1_1654 IclR family regulatory protein Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11580 gabD BAB1_1655 aldehyde dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11581 BAW_11581 BAB1_1656 putative membrane-associated alkaline phosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11582 dsbB BAB1_1657 Disulfide bond formation protein DsbB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11583 BAW_11583 BAB1_1658 HNH endonuclease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11584 BAW_11584 BAB1_1659 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11585 BAW_11585 BAB1_1660 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11586 alkA BAB1_1661 DNA-3 Methiladenine glicosidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11587 BAW_11587 BAB1_1662 Glutamyl-tRNA synthetase; class Ic:Aminoacyl-tRNA synthetase; class I this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifiestRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4;5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11588 aceB BAB1_1663 malate synthase G catalyzes the formation of malate from glyoxylate and acetyl-CoA. Zìniga-Ripa A et al. J Bac 2014. Protein expression increased in B suis after 48h macrophage infection (Al Dahouk S et al. 2008) Zuniga-Ripa et al. 2014. J Bacteriol. 196(16):3045-57;
BAW_11589 BAW_11589 BAB1_1664 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11590 BAW_11590 BAB1_1665 RNA polymerase factor sigma-32 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor isresponsible for the expression of heat shock promoters Delory et al. 2006. J Bacteriol. 188(21):7707-10;[62]Lamontagne et al. 2010. BMC Genomics. 11:300[63]
BAW_11591 BAW_11591 BAB1_1666 ribosomal large subunit pseudouridine synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11592 BAW_11592 BAB1_1667 Similar to a fimbrial protein in Mesorhizobium; Phyllobacterium Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11593 mur BAB1_1668 Manganese uptake regulator Menscher et al. 2012. J. Bacteriol. 194:561-566[64]
BAW_11594 BAW_11594 BAB1_1669 sensor histidine kinase Kim et al. 2013. J. Biol. Chem. 288:13906-13916[65]
BAW_11595 BAW_11595 BAB1_1670 Small integral membrane protein [Function unknown] Kim et al. 2013. J. Biol. Chem. 288:13906-13916;
BAW_11596 phyR BAB1_1671 Phyllosphere-induced regulator. Identical to tcaR (two-component response regulator) and bspE (secreted effector) in Caulobacter crescentus; CC3477 is differentially expressed in minimal salts media with glucose ascompared to complex media Kim et al. 2013. J. Biol. Chem. 288:13906-13916;
BAW_11597 rpoE1 BAB1_1672 RpoE1; extracytoplasmic function sigma factor; repressor of the flagellar system in Brucella melitensis Bacteria have multiple sigma factors which are active under specific conditions; the sigmafactor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription Delory et al. 2006. J Bacteriol. 188(21):7707-10;Ferooz et al. 2011. Microbiology. 157(Pt 5):1263-8[66]
BAW_11598 exsB BAB1_1673 ExsB protein involved in succinoglycan production in S. meliloti. Also known as tcaS in B melitensis Caswell et al. 2013. Infect Immun. 81(4):1040-51[67]
BAW_11599 BAW_11599 BAB1_1674 Putative 6-pyruvoyl tetrahydropterin synthase Lamontagne et al. 2010. BMC Genomics. 11:300;Kim et al. 2013. J. Biol. Chem. 288:13906-13916
BAW_11600 BAW_11600 BAB1_1675 proline-rich extensin:radical SAMfamily protein Caswell et al. 2013. Infect Immun. 81(4):1040-51;
BAW_11601 BAW_11601 BAB1_1676 photosystem reaction center subunit H Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11602 BAW_11602 BAB1_1678 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11603 exbB BAB1_1679 tonB-system energizer ExbB ABC transporter ATPase; exbB: MotA/TolQ/ExbB proton channel Danese et al. 2004. Infect Immun. 72(10):5783-90;
BAW_11604 exbD BAB1_1680 biopolymer transport protein ExbD/TolR Danese et al. 2004. Infect Immun. 72(10):5783-90;
BAW_11605 tonB BAB1_1681 cell envelope biogenesis protein TonB Danese et al. 2004. Infect Immun. 72(10):5783-90;
BAW_11606 BAW_11606 BAB1_1682 Pseudogene. Frame shift. Similar to BS1330_I1663. Predicted periplasmic protein [Function unknown]; conserved predicted protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11607 BAW_11607 BAB1_1683 macrolide export ATP-binding/permease MacB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11608 BAW_11608 BAB1_1684 phosphoribulokinase ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11609 BAW_11609 BAB1_1685 secretion protein HlyD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11610 dut BAB1_1687 deoxyuridine 5'-triphosphate nucleotidohydrolase catalyzes the formation of dUMP from dUTP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11611 BAW_11611 BAB1_1688 AsnC family regulatory protein Fu et al. 2012. PLoS One. 7(2):e29552[68]
BAW_11612 BAW_11612 BAB1_1689 capsular polysaccharide biosynthesis protein J Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11613 BAW_11613 BAB1_1690 glutamine amidotransferase; class-II Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11614 mbfA BAB1_1691 Fe exporter Martinson and Roop (manuscript in preparation);
BAW_11615 BAW_11615 BAB1_1692 proline/betaine transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11616 BAW_11616 BAB1_1693 basic-leucine zipper (bZIP) transcription factor Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11617 BAW_11617 BAB1_1694 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11618 purA BAB1_1695 adenylosuccinate synthetase catalyzes the formation of N6-(1;2;-dicarboxyethyl)-AMP from L-aspartate; inosine monophosphateandGTP in AMP biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11619 BAW_11619 BAB1_1696 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11620 BAW_11620 BAB1_1697 D-3-phosphoglycerate dehydrogenase catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis;can also reduce alpha ketoglutarate to form 2-hydroxyglutarate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11621 BAW_11621 BAB1_1698 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11622 serC BAB1_1699 phosphoserine aminotransferase catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and2-oxoglutarate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11623 BAW_11623 BAB1_1700 bile acid:sodium symporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11624 BAW_11624 BAB1_1701 opacity-associated protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11625 glmM BAB1_1702 Phosphoglucosamine mutase catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11626 ftsH BAB1_1703 ATP-dependent zinc metalloproteaseFtsH Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11627 BAW_11627 BAB1_1704 tRNA(Ile)-lysidine synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11628 BAW_11628 BAB1_1705 tol-pal system protein YbgF Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11629 BAW_11629 BAB1_1706 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11630 BAW_11630 BAB1_1707 pal= peptidoglycan-associated lipoprotein; also called omp16 Tibor et al. 1994. Infect Immun. 62(9):3633-9[69]
BAW_11631 BAW_11631 BAB1_1708 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11632 tolB BAB1_1709 translocation protein TolB forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins andwith the C-terminal domain of inner membrane protein TolA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11633 tolA BAB1_1710 Proline-rich region:Proline-rich extensin:Histamine H3 receptor Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11634 BAW_11634 BAB1_1711 biopolymer transport protein ExbD/TolR Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11635 tolQ BAB1_1712 MotA/TolQ/ExbB proton channel Lamontagne et al. 2010. BMC Genomics. 11:300;Brucella abortus 2308; accesion number NC_007618
BAW_11636 BAW_11636 BAB1_1713 4-hydroxybenzoyl-CoA thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11637 ruvB BAB1_1714 Holliday junction DNA helicase RuvB promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration;RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11638 ruvA BAB1_1715 Holliday junction DNA helicase RuvA plays an essential role in ATP-dependent branch migration of the Holliday junction Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11639 ruvC BAB1_1716 Holliday junction resolvase endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction bindingproteinRuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11640 BAW_11640 BAB1_1717 AraC family transcriptional regulator; putatively involved in degradation CtrA (relate with cell cycle) in Caulobacter McGrath et al. 2006. Cell. 124(3):535-47[70]
BAW_11641 cgm BAB1_1718 Cyclic beta-1;2-glucan O-succinyltransferase Responsible for succinylation of cyclic beta-1;2-glucan Roset et al. 2006. J Bacteriol. 188(14):5003-13[71]
BAW_11642 BAW_11642 BAB1_1719 thiamine-phosphate pyrophosphorylase catalyzes the formation of thiamine monophosphate from 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate and 4-methyl-5-(2-phosphono-oxyethyl)-thiazole Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11643 BAW_11643 BAB1_1720 podJ-like similar to BR1708; conserved predicted protein; smaller version compared to podJ (BAB2_0413); witha Sel1 peptidoglycan binding domain too Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11644 BAW_11644 BAB1_1721 predicted protein Corresponds to BruAb1_1694; BR1709 and BS1330_I1703 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11645 efp BAB1_1722 elongation factor P Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11646 BAW_11646 BAB1_1723 inositol phosphatase/fructose-1;6-bisphosphatase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11647 BAW_11647 BAB1_1724 predicted protein No differences found to consider it a pseudogene. Corresponds to BruAb1_1697; BR1712 and BS1330_I176 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11648 BAW_11648 BAB1_1725 flagellar motor protein MotA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11649 BAW_11649 BAB1_1726 COG1360 Flagellar Motor Protein Common and specificÖBrucella melitensisÖantigens for humans; similar to BMEI0324 Liang et al. PLoS Negl Trop Dis. 2010 May 4;4(5):e673;
BAW_11650 BAW_11650 BAB1_1727 uridine kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11651 rpmE BAB1_1728 50S ribosomal protein L31 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain aCxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5; L18; and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11652 BAW_11652 BAB1_1729 transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11653 gntR17 BAB1_1730 GntR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11654 bioY BAB1_1731 BioY protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11655 BAW_11655 BAB1_1732 2Fe-2S ferredoxin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11656 BAW_11656 BAB1_1733 RNA-binding region RNP-1 (RNA recognition motif):Integral membrane protein TerC family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11657 BAW_11657 BAB1_1734 metallophosphoesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11658 BAW_11658 BAB1_1735 5-formyltetrahydrofolate cyclo-ligase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11659 BAW_11659 BAB1_1736 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11660 BAW_11660 BAB1_1737 Similar to cell division protein ZapA Mesorhizobium sp Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11661 BAW_11661 BAB1_1738 predicted protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11662 BAW_11662 BAB1_1739 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11663 tkt BAB1_1740 transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes; tktA expressed during exponential growth and the tktB during stationary phase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11664 gap BAB1_1741 Glyceraldehyde 3-phosphate dehydrogenase:TrkA potassium uptake protein:Glyceraldehyde-3-phosphate dehydrogenase; type I Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11665 pgk BAB1_1742 Phosphoglycerate kinase:G-proteinbeta WD-40 repeat Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11666 BAW_11666 BAB1_1743 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11667 BAW_11667 BAB1_1744 propionyl-CoA synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11668 BAW_11668 BAB1_1745 glucose/ribitol dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11669 BAW_11669 BAB1_1746 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11670 deoR5 BAB1_1747 DeoR family regulatory protein Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11671 BAW_11671 BAB1_1748 phenylacetic acid degradation-likeprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11672 BAW_11672 BAB1_1749 Uncharacterized protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11673 BAW_11673 BAB1_1750 NAD(P)H quinone oxidoreductase; PIG3 family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11674 BAW_11674 BAB1_1751 Uncharacterized protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11675 BAW_11675 BAB1_1752- BAB1_1753 Pseudogene. Frame shift at position 1676720; similar to BS1330_I1734 and BruAb1_1725. Transporter Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11676 BAW_11676 BAB1_1754 Uncharacterized protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11677 BAW_11677 BAB1_1755 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11678 BAW_11678 BAB1_1756 Uncharacterized protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11679 BAW_11679 BAB1_1757 N5-carboxyaminoimidazole ribonucleotide mutaseÖ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11680 purK BAB1_1758 ATP-dependent carboxylate-amine ligase-like; ATP-grasp:Phosphoribosylaminoimidazole carboxylase; ATPase subunit With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11681 rpmJ BAB1_1759 50S ribosomal protein L36 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11682 BAW_11682 BAB1_1760 Ö2-hydroxy-6-oxo-2;4-heptadienoatehydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11683 pykM BAB1_1761 pyruvate kinase catalyzes the formation of phosphoenolpyruvate from pyruvate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11684 BAW_11684 BAB1_1762 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11685 BAW_11685 BAB1_1763 N-formylglutamate amidohydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11686 BAW_11686 BAB1_1764 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11687 BAW_11687 BAB1_1765 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11688 BAW_11688 BAB1_1766 elongation factor 3 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11689 BAW_11689 BAB1_1767 predicted protein similar to BR1754 and BruAb1_1739 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11690 BAW_11690 BAB1_1768 Pseudogene. Frame shift mutation at position 1687086; similar to BS1330_I1749; lipoprotein; predicted Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11691 BAW_11691 BAB1_1769 thiamin pyrophosphokinase catalytic subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11692 thiB BAB1_1770 thiamine transporter substrate binding subunit Thiamine-binding periplasmic protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11693 thiP BAB1_1771 thiamine transporter membrane protein permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphateintothecell; repressed in presence of exogenous thiamine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11694 BAW_11694 BAB1_1772 thiamine ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11695 BAW_11695 BAB1_1773 Peptidase family M48:Neutral zincmetallopeptidases; zinc-binding region Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11696 BAW_11696 BAB1_1774 molybdenum cofactor sulfurase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11697 rpoH2 BAB1_1775 RNA polymerase factor sigma-32 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production Delory et al. 2006. J Bacteriol. 188(21):7707-10;
BAW_11698 BAW_11698 BAB1_1776 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11699 BAW_11699 BAB1_1777 transcription factor CarD Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11700 fdxA BAB1_1778 7Fe ferredoxin:4Fe-4S ferredoxin;iron-sulfur binding domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11701 BAW_11701 BAB1_1779 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11702 BAW_11702 BAB1_1780 RNA-binding protein S4 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11703 BAW_11703 BAB1_1781 DEAD/DEAH box helicase:Helicase; C-terminal:ATP/GTP-binding site motif A (P-loop):Aldehyde dehydrogenase Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11704 BAW_11704 BAB1_1782 predicted protein Corresponds to BR1771 and BS1330_I1765. This gene match in part with acetyl-CoA acetyltransferase (next gene) Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11705 phbA-1 BAB1_1783 acetyl-CoA acetyltransferase Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A.It can also act as a thiolase; catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11706 BAW_11706 BAB1_1784 Putative GlcG protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11707 rpmF BAB1_1785 50S ribosomal protein L32 some L32 proteins have zinc finger motifs consisting of CXXC while others do not Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11708 mtgA BAB1_1786 monofunctional biosynthetic peptidoglycan transglycosylase glycosyltransferase; polymerizes glycan strands in the peptidoglycan Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11709 BAW_11709 BAB1_1787 farnesyl-diphosphate synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11710 ispG BAB1_1788 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase catalyzes the conversion of 2C-methyl-D-erythritol 2;4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11711 BAW_11711 BAB1_1789 3-hydroxybutyrate dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11712 BAW_11712 BAB1_1790 membrane protein MosC Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11713 pyc BAB1_1791 pyruvate carboxylase biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11714 BAW_11714 BAB1_1792 amino acid ABC transporter substrate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11715 BAW_11715 BAB1_1793 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11716 gasE BAB1_1794 GABA ABC transporter substrate-binding protein Leu/Ile/Val-binding protein homolog 1 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11717 gasD BAB1_1795 membrane protein (GABA transporter) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11718 gasC BAB1_1796 ATPase of GABA transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11719 BAW_11719 BAB1_1797 Pseudogene. Frame shift and deletion. Similart to BS1330_I1783. ATPase of GABA transporter, branched chain-amino acid transporter ATP-binding protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11720 gasB BAB1_1798 GABA transporter permease inner-membrane translocator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11721 gasA BAB1_1799 GABA ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11722 BAW_11722 BAB1_1800 prpA B-cell mitogen with immune modulatory function prpA probably with a set of other virulence factors; is involved in the establishment of chronicity and in inducing a temporal anergic state in the host Spera et al. 2006. Proc Natl Acad Sci U S A. 103(44):16514-9;
BAW_11723 BAW_11723 BAB1_1801 D-amino acid dehydrogenase TrkA potassium uptake protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11724 BAW_11724 BAB1_1802 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11725 gntR8 BAB1_1803 GntR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11726 BAW_11726 BAB1_1804 Bacterial regulatory protein; MarRfamily Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11727 BAW_11727 BAB1_1805 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11728 atpC BAB1_1806 ATP synthase epsilon chain part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involvedinproducing ATP from ADP in the presence of the proton motive force across the membrane Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11729 atpD BAB1_1807 ATP synthase subunit beta Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chainis aregulatory subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11730 atpG BAB1_1808 F0F1 ATP synthase subunit gamma Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11731 atpA BAB1_1809 F0F1 ATP synthase subunit alpha produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chainisacatalytic subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11732 atpH BAB1_1810 F0F1 ATP synthase subunit delta Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit ispart of the catalytic core of the ATP synthase complex Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11733 BAW_11733 BAB1_1811 Putative membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11734 priA BAB1_1812 primosome assembly protein PriA binding of PriA to forked DNA starts the assembly of the primosome; also possesses 3'-5' helicase activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11735 talC BAB1_1813 fructose-6-phosphate aldolase similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcusjanaschii shows transaldolase activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11736 BAW_11736 BAB1_1814 Putative uncharacterized protein protein containing Lipopolysaccharide-assembly; LptE domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11737 leuS BAB1_1815 leucyl-tRNA synthetase leucine—tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linkingcarboxylgroup to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes; the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA; but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11738 BAW_11738 BAB1_1816 YggS family pyridoxal phosphate enzyme Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11739 BAW_11739 BAB1_1817 fusaric acid resistance protein FusB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11740 BAW_11740 BAB1_1818 Putative usg protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11741 BAW_11741 BAB1_1819 acetyl-CoA synthetase Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11742 BAW_11742 BAB1_1820 Uncharacterized protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11743 htpX BAB1_1821 heat shock protein HtpX putative metalloprotease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11744 BAW_11744 BAB1_1822 MFS transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11745 BAW_11745 BAB1_1823 heparinase II/III family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11746 purH BAB1_1824 purine biosynthesis protein purH involved in de novo purine biosynthesis. Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11747 BAW_11747 BAB1_1825- BAB1_1826 Pseudogene. This region contains a premature stop; similar to BS1330_I1811 and BruAb1_1797; membrane protein; predicted Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11748 BAW_11748 BAB1_1827 NAD-glutamate dehydrogenase Ronneau et al. 2015. Crit Rev Microbiol. 10:1-19;
BAW_11749 BAW_11749 BAB1_1828 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11750 BAW_11750 BAB1_1829 membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11751 BAW_11751 BAB1_1830 LemA family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11752 BAW_11752 BAB1_1831 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11753 rpsP BAB1_1832 30S ribosomal protein S16 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of30S; in Escherichia coli this protein has nuclease activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11754 BAW_11754 BAB1_1833 chorismate mutase catalyzes the interconversion of chorismate to prephenate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11755 ffh BAB1_1834 signal recognition particle protein Disease resistance protein:GTP-binding signal recognition particle (SRP54) G-domain:ATP/GTP-binding site motif A (P-loop):AAA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11756 BAW_11756 BAB1_1835 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11757 BAW_11757 BAB1_1836 lytic murein transglycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11758 BAW_11758 BAB1_1837 carbonate dehydratase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11759 BAW_11759 BAB1_1838 pyridoxamine kinase catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11760 BAW_11760 BAB1_1839 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11761 mmsA BAB1_1840 methylmalonate-semialdehyde dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11762 lysR14 BAB1_1841 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86[72]
BAW_11763 BAW_11763 BAB1_1842 Protein with domain of uncharacterized membrane protein YoaK; UPF0700 family [Function unknown] Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11764 BAW_11764 BAB1_1843 transglycosylase-associated protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11765 BAW_11765 BAB1_1844 RNA pyrophosphohydrolase hydrolyzes diadenosine polyphosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11766 BAW_11766 BAB1_1845 peptidase S41 PDZ/DHR/GLGF domain:Tail specific protease:Carboxyl-terminal protease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11767 BAW_11767 BAB1_1846 membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11768 BAW_11768 BAB1_1847 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11769 BAW_11769 BAB1_1848 50S rRNA methyltransferase SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia colithisprotein methylates pseudouridine at position 1915 of the 23S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11770 BAW_11770 BAB1_1849 ribosome-associated protein IOJAP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11771 nadD BAB1_1850 nicotinic acid mononucleotide adenylyltransferase transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) whichis then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11772 proA BAB1_1851 gamma-glutamyl phosphate reductase Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11773 proB BAB1_1852 glutamate 5-kinase catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11774 cgtA BAB1_1853 GTPase cgtA essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11775 BAW_11775 BAB1_1854 putative adhesin BtaF trimeric autotransporter in B. suis This autotransporter is one of the four predicted in Brucella genomes and it has been suggested that the combination present in each genome is related to host and tissue tropism. Other autotransporters with different degree of similarity are encoded in BOV_A0152; BOV_A1053; and BOV_1937 (pseudogene in B ovis; marine isolates and B abortus). All are pseudogenes in B melitensis 16M Ruiz-Ranwez et al. 2013. Infect Immun. 81(3):996-1007;Ruiz-Ranwez et al. 2013. Infect Immun. 81(3):996-1007[73]
BAW_11776 BAW_11776 BAB1_1855 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11777 BAW_11777 BAB1_1856 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11778 rpmA BAB1_1857 50S ribosomal protein L27 involved in the peptidyltransferase reaction during translation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11779 rplU BAB1_1858 50S ribosomal protein L21 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11780 BAW_11780 BAB1_1860 Cro/Cl family transcriptional regulator SAM-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11781 BAW_11781 BAB1_1861 branched-chain amino acid ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11782 BAW_11782 BAB1_1862 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11783 BAW_11783 BAB1_1863 integrase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11784 BAW_11784 BAB1_1864 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11785 BAW_11785 BAB1_1865 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11786 BAW_11786 BAB1_1866 peptidase M24 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11787 BAW_11787 BAB1_1867 ErfK/YbiS/YcfS/YnhG Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11788 BAW_11788 BAB1_1868 chaperone protein ClpB Chaperonin clpA/B:ATP/GTP-binding site motif A (P-loop):AAA ATPase:AAA ATPase; central region:Clp;Nterminal Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11789 BAW_11789 BAB1_1869 Uncharacterized protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11790 BAW_11790 BAB1_1870 Protein containing Domain of unknown function (DUF4167) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11791 BAW_11791 BAB1_1871 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11792 prfA BAB1_1872 peptide chain release factor 1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11793 ptsP BAB1_1873 phosphoenolpyruvate-protein phosphotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;Dozot et al. 2010. PLoS One. 5(9). pii: e12679
BAW_11794 BAW_11794 BAB1_1874 aspartate kinase catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; in Bacillus; lysinesensitive; regulated by response to starvation. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11795 ubiG BAB1_1875 3-demethylubiquinone-9 3-methyltransferase Involved in ubiquinone biosynthesis Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11796 BAW_11796 BAB1_1876 Pseudogene. Frame shift; similar to BS1330_I1867. Transporter protein Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11797 BAW_11797 BAB1_1877 Uncharacterized protein Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11798 BAW_11798 BAB1_1878 amidohydrolase nitrilase/cyanide hydratase/apolipoprotein N-acyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11799 grxC BAB1_1879 glutaredoxin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11800 BAW_11800 BAB1_1880 amidophosphoribosyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11801 BAW_11801 BAB1_1881 SAM-dependent methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11802 BAW_11802 BAB1_1882 MFS transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11803 BAW_11803 BAB1_1883 Uncharacterized conserved protein;tellurite resistance protein B (TerB) family [Function unknown] similar to BS1330_I1876 and BruAb1_1859 Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11804 hemY BAB1_1884 heme biosynthesis protein HemY Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11805 BAW_11805 BAB1_1885 Putative chromosome segregation protein SMC; common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition Common and specific Brucella melitensis antigens for goats; similar to BMEI0178 Lamontagne et al. 2010. BMC Genomics. 11:300;Liang et al. PLoS Negl Trop Dis. 2010 May 4;4(5):e673[74]
BAW_11806 hemD BAB1_1886 uroporphyrinogen III methyltransferase catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11807 hemC BAB1_1887 hydroxymethylbilane synthase transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11808 gcp BAB1_1888 protein kinase:Glycoprotease (M22)metalloprotease in most organisms; only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties; iron-binding; ATP-binding; and AP endonuclease activity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11809 gpsA BAB1_1889 gpsA: Adrenodoxin reductase:NAD-dependent glycerol-3-phosphate dehydrogenase catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11810 BAW_11810 BAB1_1890 YciI-related protein;Uncharacterized conserved protein YciI; contains a putative active-site phosphohistidine [General function prediction only] unknown function; YciI from Haemophilus influenzae presents crystal structure similarity toa muconolactone isomerase; but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11811 BAW_11811 BAB1_1891 ubiquinol-cytochrome C reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11812 BAW_11812 BAB1_1892 50S ribosomal protein L11 methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11813 BAW_11813 BAB1_1893 transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11814 gntR4 BAB1_1894 GntR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11815 BAW_11815 BAB1_1895 cell division protein FtsK DNA pump involved in cell division and final steps of chromosomes segregation; putative Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11816 amt BAB1_1896 ammonium transporter Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11817 BAW_11817 BAB1_1897 Acyl-CoA thioesterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11818 BAW_11818 BAB1_1898 2-octaprenyl-6-methoxyphenyl hydroxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11819 BAW_11819 BAB1_1899 glyoxalase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11820 sdhB BAB1_1900 succinate dehydrogenase iron-sulfur subunit part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer oftetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11821 sdhA BAB1_1901 Fumarate reductase/succinate dehydrogenase part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer oftetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11822 BAW_11822 BAB1_1902 succinate dehydrogenase hydrophobic membrane anchor protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11823 sdhC BAB1_1903 succinate dehydrogenase succinate dehydrogenase; cytochrome subunit B Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11824 BAW_11824 BAB1_1904 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11825 leuC BAB1_1905 isopropylmalate isomerase large subunit dehydratase component; catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11826 rplS BAB1_1906 50S ribosomal protein L19 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11827 BAW_11827 BAB1_1907- BAB1_1908 Pseudogene. Frame shift and 2 bp deletion at 1841687 position. Similar to BS1330_I1902 and BruAb1_1884. Nitrate reductase Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11828 BAW_11828 BAB1_1909 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11829 BAW_11829 BAB1_1910 Putative protein with ACT domain commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme. Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11830 BAW_11830 BAB1_1911 antibiotic biosynthesis monooxygenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11831 BAW_11831 BAB1_1912 Putative Members of NIPSNAP familyprotein This family include many predicted proteins. It also includes members of the NIPSNAP familywhichhave putative roles in vesicular transport Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11832 arsR4 BAB1_1913 ArsR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11833 trmD BAB1_1914 tRNA (guanine-N(1)-)-methyltransferase methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl grouptotRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11834 rimM BAB1_1915 16S rRNA-processing protein RimM Essential for efficient processing of 16S rRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11835 xerC BAB1_1916 site-specific tyrosine recombinaseXerC site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively tospecific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11836 BAW_11836 BAB1_1917 GumN family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11837 lpdA-2 BAB1_1918 dihydrolipoamide dehydrogenase Catalyzes the oxidation of dihydrolipoamide to lipoamide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11838 BAW_11838 BAB1_1919 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11839 BAW_11839 BAB1_1920 lysine transporter LysEÖ/YggA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11840 BAW_11840 BAB1_1921 membrane protein with domines MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11841 sucB BAB1_1922 dihydrolipoamide succinyltransferase Biotin/lipoyl attachment:Antifreeze protein; type I:Catalytic domain of components of various dehydrogenase complexes Lamontagne et al. 2010. BMC Genomics. 11:300;
BAW_11842 sucA BAB1_1923 2-oxoglutarate dehydrogenase E1 component SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formationof succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide Dozot et al. 2010. PLoS One. 5(9). pii: e12679;
BAW_11843 BAW_11843 BAB1_1924 Pseudogene. Frame shift; highly similar to BS1330_I1918 Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11844 sucD BAB1_1925 succinyl-CoA synthetase subsunit alpha Catalyzes the only substrate-level phosphorylation in the TCA cycle Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11845 sucC BAB1_1926 succinyl-CoA synthetase subunit beta catalyzes the interconversion of succinyl-CoA and succinate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11846 mdh BAB1_1927 malate dehydrogenase Catalyzes the reversible oxidation of malate to oxaloacetate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618;http://www.ncbi.nlm.nih.gov/pubmed/16299333/ Han et al. 2014. ScientificWorldJournal. 973751]
BAW_11847 BAW_11847 BAB1_1928 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11848 BAW_11848 BAB1_1929 ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11849 omp19 BAB1_1930 lipoprotein Omp19 Tibor et al. 2002. Infect Immun. 70(10):5540-6;[75]Kovach et al. 1997. Microb. Pathogen. 22:241-246[76]
BAW_11850 BAW_11850 BAB1_1931 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11851 dapF BAB1_1932 diaminopimelate epimerase involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11852 BAW_11852 BAB1_1933 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11853 ftsY BAB1_1934 cell division protein FtsY Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11854 ispZ BAB1_1935 intracellular septation protein A Involved in cell division; probably involved in intracellular septation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11855 gloB BAB1_1936 Hydroxyacylglutathione hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11856 BAW_11856 BAB1_1937- BAB1_1938 Pseudogene. Frame shift; similar to BS1330_I1931 and BruAb1_1913 Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11857 BAW_11857 BAB1_1939 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11858 BAW_11858 BAB1_1940 NTP pyrophosphohydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11859 BAW_11859 BAB1_1941 N-acetyltransferase GCN5 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11860 argJ BAB1_1942 arginine biosynthesis bifunctionalprotein ArgJ bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in argininebiosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11861 BAW_11861 BAB1_1943 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11862 BAW_11862 BAB1_1944 PpiC-type peptidyl-prolyl cis-trans isomerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11863 BAW_11863 BAB1_1945 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11864 secA BAB1_1946 preprotein translocase subunit SecA functions in protein export; can interact with acidic membrane phospholipids and the SecYEGproteincomplex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11865 BAW_11865 BAB1_1947 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11866 BAW_11866 BAB1_1948 bspF: VirB type IV secreted effector BspF is part of the three VirB effectors; BspA; BspB and BspF that inhibited protein secretion and contributed to varying degrees to bacterial inhibition of host protein secretion; pathogen intracellular growth and persistence in the liver of infected mice. Myeni et al. 2013. PLoS Pathog. 9(8):e1003556;
BAW_11867 BAW_11867 BAB1_1949 - BAB1_1950 Pseudogene. This region contains a frame shift; similar to BS1330_I1942 and BruAb1_1924 Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11868 BAW_11868 BAB1_1951 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11869 BAW_11869 BAB1_1952 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11870 lysR9 BAB1_1953 transcriptional regulator LysR Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11871 BAW_11871 BAB1_1954 amino acid ABC transporter substrate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11872 BAW_11872 BAB1_1955 Pseudogene. Frame shift. Similar to BMEI0113 (asparagine transport system permease protein. Polar amino acid ABC transporter permease) Brucella melitensis 16M genome; accession number NC_003317;DelVecchio et al. 2002. Proc Natl Acad Sci U S A. 99(1):443-8
BAW_11873 BAW_11873 BAB1_1956 ABC transporter permease binding-protein dependent transport system inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11874 BAW_11874 BAB1_1957 arginine ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11875 BAW_11875 BAB1_1958 arginase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11876 aspA BAB1_1959 aspartate ammonia-lyase catalyzes the formation of fumarate from aspartate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11877 BAW_11877 BAB1_1960 arginine ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11878 BAW_11878 BAB1_1961 asparaginase/glutaminase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11879 gntR13 BAB1_1962 GntR family transcriptional regulator Haine et al; Infect Immun. 2005 Sep;73(9):5578-86;
BAW_11880 BAW_11880 BAB1_1963 L-asparaginase asparaginase/glutaminase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11881 BAW_11881 BAB1_1964 MFS transporter previously known as tetracycline resistance protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11882 BAW_11882 BAB1_1965 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11883 BAW_11883 BAB1_1966 methionine gamma-lyase catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11884 BAW_11884 BAB1_1967 Universal stress protein (Usp):Uspdomain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11885 BAW_11885 BAB1_1968 cysteine synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11886 BAW_11886 BAB1_1969 Pseudogene. Frame shift; similar to BS1330_I1962 Brucella suis 1330 genome; accesion number NC_004310;Paulsen et al. 2002. Proc Natl Acad Sci U S A. 99(20):13148-53
BAW_11887 BAW_11887 BAB1_1970 3-hydroxybutyryl-CoA dehydrogenase converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11888 etfA BAB1_1971 Antifreeze protein; type I:Electron transfer flavoprotein; alpha subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11889 etfB BAB1_1972 electron transfer flavoprotein subunit beta Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11890 BAW_11890 BAB1_1973 7-cyano-7-deazaguanine synthase Previously known as ExsB protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11891 BAW_11891 BAB1_1974 6-pyruvoyl tetrahydropterin synthase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11892 BAW_11892 BAB1_1975 7-carboxy-7-deazaguanine synthase folate biosynthesis; purine biosynthesis. Regulated by MucR. Sinorhizobium meliloti SMb20938 orthologis related to succinoglycan biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11893 BAW_11893 BAB1_1976 cob(I)yrinic acid a;c-diamide adenosyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11894 BAW_11894 BAB1_1977 putative membrane protein with Hypoxia induced domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11895 BAW_11895 BAB1_1978 short chain dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11896 BAW_11896 BAB1_1979 ribonuclease BN Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11897 BAW_11897 BAB1_1980 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11898 BAW_11898 BAB1_1981 Sodium:dicarboxylate symporter Thioredoxin type domain:Thioredoxin domain 2 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11899 BAW_11899 BAB1_1982 argininosuccinate lyase catalyzes the formation of arginine from (N-L-arginino)succinate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11900 BAW_11900 BAB1_1983 Putative protein within domain LPAM_2 for Prokaryotic lipoprotein-attachment site Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11901 lysA BAB1_1984 diaminopimelate decarboxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11902 BAW_11902 BAB1_1985 Unnamed protein product; TIGR02302family protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11903 hpt BAB1_1986 hypoxanthine phosphoribosyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11904 BAW_11904 BAB1_1987 SAM-dependent methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11905 hisC BAB1_1988 histidinol-phosphate aminotransferase catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamateinhistidine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11906 BAW_11906 BAB1_1989 cyclohexadienyl dehydrogenase dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate andtheformation of tyrosine from arogenate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11907 BAW_11907 BAB1_1990 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11908 BAW_11908 BAB1_1991 gamma-glutamyl cyclotransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11909 BAW_11909 BAB1_1992 membrane protein; YGGT family Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11910 ppa BAB1_1993 Inorganic pyrophosphatase catalyzes the hydrolysis of pyrophosphate to phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11911 BAW_11911 BAB1_1994 1-acyl-sn-glycerol-3-phosphate acyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11912 BAW_11912 BAB1_1995 Putative membrane protein YdcF-like domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11913 ftsX BAB1_1996 cell division protein FtsX Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11914 ftsE BAB1_1997 ABC transporter ATPase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11915 BAW_11915 BAB1_1998 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11916 BAW_11916 BAB1_1999 Uncharacterized protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11917 BAW_11917 BAB1_2000 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11918 BAW_11918 BAB1_2001 aquaporin Z porin involved in osmoregulation allowing water to move into and out of the cell in response toosmotic pressure Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11919 BAW_11919 BAB1_2002 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11920 BAW_11920 BAB1_2003 Putative lolA lipoprotein chaperone Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11921 BAW_11921 BAB1_2004 exodeoxyribonuclease III Exonuclease III; encoded by the xthA gene plays a central role in the base excision pathwayofDNArepair in bacteria; AP endonuclease activity Hornback and Roop. 2006. J. Bacteriol. 188:1295-1300;
BAW_11922 BAW_11922 BAB1_2005 BPE005 VirB type IV secreted protein effector Contains a cNMP binding domain but is unable to bind cAMP and cGMP. Promotes hepatic pro-fibrotic response via TGF-B1 Arriola-Benitez et al. 2015. Infect Immun. 84(2):598-606;[77]Marchesini et al. 2011. Cell Microbiol. 13(8):1261-74[78]
BAW_11923 cenR BAB1_2006 Two-component response regulator CenR Response regulator receiver:Transcriptional regulatory protein; C terminal Zhang et al. 2009. Int J Biol Sci.5(6):570-7[79]
BAW_11924 BAW_11924 BAB1_2007 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11925 BAW_11925 BAB1_2008 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11926 BAW_11926 BAB1_2009 Pseudogene. Frame shift; similar to BS1330_I2003 (BR2009); bigA adhesin with a bacterial immunoglobulin-like domain Czibener et al. 2016. Cell Microbiol. 2016 Apr;18(4):500-13[80]
BAW_11927 BAW_11927 BAB1_2010 glyceraldehyde 3-phosphate dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11928 BAW_11928 BAB1_2011 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11929 BAW_11929 BAB1_2012 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11930 BAW_11930 BAB1_2013 - BAB1_2014 Pseudogene. Premature stop codon; similar to BS1330_I2007 and BruAb1_1988; outer membrane autotransporter Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11931 BAW_11931 BAB1_2015 Putative membrane protein with domain YhhQ related with membrane protein YhhQ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11932 rpmB BAB1_2016 50S ribosomal protein L28 required for 70S ribosome assembly Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11933 BAW_11933 BAB1_2017 Putative protein of bacterial family of putative lipoproteins (DUF3108) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11934 zntR BAB1_2018 Zn responsive regulator of zntA Sheehan et al. 2015. J. Bacteriol. 197(9):1582-91[81]
BAW_11935 zntA BAB1_2019 Zn exporter Sheehan et al. 2015. J. Bacteriol. 197(9):1582-91;
BAW_11936 BAW_11936 BAB1_2020 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11937 BAW_11937 BAB1_2021 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11938 BAW_11938 BAB1_2022 cobalt chelatase subunit CobT Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11939 cobS BAB1_2023 aerobic cobaltochelatase subunit CobS Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11940 BAW_11940 BAB1_2024 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11941 BAW_11941 BAB1_2025 molecular chaperone DnaJ Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11942 BAW_11942 BAB1_2026 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11943 bolA BAB1_2027 BolA family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11944 BAW_11944 BAB1_2028 Putative membrane protein with domain CorB relate to Mg2+ and Co2+ transporter CorB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11945 aroB BAB1_2029 3-dehydroquinate synthase catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functionsin aromatic amino acid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11946 aroK BAB1_2030 shikimate kinase catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11947 BAW_11947 BAB1_2031 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11948 xerD BAB1_2032 site-specific tyrosine recombinaseXerD site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively tospecific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11949 accA BAB1_2033 acetyl-CoA carboxylase carboxyltransferase subunit alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of twoalpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11950 BAW_11950 BAB1_2034 Putative protein with domain YafK related to Murein L;D-transpeptidase YafK [Cell wall/membrane/envelope biogenesis] Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11951 BAW_11951 BAB1_2035 response regulator SirA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11952 BAW_11952 BAB1_2036 ATP-binding protein with domain CobW_C related to Cobalamin synthesis protein cobW C-terminal domain Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11953 BAW_11953 BAB1_2037 D-alanyl-D-alanine carboxypeptidase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11954 BAW_11954 BAB1_2038 N-acyl-L-amino acid amidohydrolase Previously known as antifreeze protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11955 BAW_11955 BAB1_2039 3-oxoacyl-ACP reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11956 BAW_11956 BAB1_2040 aldehyde-activating protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11957 BAW_11957 BAB1_2041 ATP-binding protein ATP/GTP-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11958 BAW_11958 BAB1_2042 alanine-phosphoribitol ligase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11959 BAW_11959 BAB1_2043 3-ketoacyl-ACP reductase catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11960 BAW_11960 BAB1_2044 GMC family oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11961 BAW_11961 BAB1_2045 sorbosone dehydrogenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11962 BAW_11962 BAB1_2046 enoyl-CoA hydratase/isomerase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11963 BAW_11963 BAB1_2047 - BAB1_2048 Pseudogene. Frame shift, similar to BS1330_I2041 and BruAb1_2022; acetyl-CoA-transferase subunit Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_11964 BAW_11964 BAB1_2049 1;5-anhydro-D-fructose reductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11965 BAW_11965 BAB1_2050 LacI family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11966 BAW_11966 BAB1_2051 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11967 BAW_11967 BAB1_2052 alkanal monooxygenase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11968 BAW_11968 BAB1_2053 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11969 BAW_11969 BAB1_2054 ABC transporter substrate-bindingprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11970 BAW_11970 BAB1_2055 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11971 BAW_11971 BAB1_2056 ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11972 BAW_11972 BAB1_2057 ABC transporter ATP-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11973 holA BAB1_2058 DNA polymerase III subunit delta required for the assembly and function of the DNAX complex which are required for the assemblyof thebeta subunit onto primed DNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11974 parB BAB1_2059 chromosome partitioning protein ParB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11975 parA BAB1_2060 chromosome partitioning protein ParA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11976 gidB BAB1_2061 16S rRNA methyltransferase GidB glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position ofguanosine in position 527 of 16S rRNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11977 gidA BAB1_2062 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethylmodification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11978 trmE BAB1_2063 tRNA modification GTPase TrmE in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine; which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11979 BAW_11979 BAB1_2064 Putative uncharacterized conservedprotein YyaL; SSP411 family; contains thoiredoxin and six-hairpin glycosidase-like domains Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11980 rho BAB1_2065 transcription termination factor Rho An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11981 BAW_11981 BAB1_2066 Membrane protein with domain TIGR00701 family protein; It appears this conserved predicted integral membrane protein is found only in gram negative bacteria Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11982 hemE BAB1_2067 uroporphyrinogen decarboxylase catalyzes the formation of coproporphyrinogen from uroporphyrinogen III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11983 BAW_11983 BAB1_2068 phosphoenolpyruvate synthetase regulatory protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11984 maf-2 BAB1_2069 septum formation protein Maf Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11985 aroE BAB1_2070 shikimate 5-dehydrogenase AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11986 coaE BAB1_2071 dephospho-CoA kinase catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzymeA; involved in coenzyme A biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11987 dnaQ BAB1_2072 DNA polymerase III subunit epsilon 3'-5' exonuclease of DNA polymerase III Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11988 secB BAB1_2073 preprotein translocase subunit SecB molecular chaperone that is required for the normal export of envelope proteins out of thecellcytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11989 fxsA BAB1_2074 exclusion suppressor FxsA F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the Fplasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11990 BAW_11990 BAB1_2075 calcium-binding protein calcium-binding EF-hand Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11991 BAW_11991 BAB1_2076 transglycosylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11992 mutS BAB1_2077 DNA mismatch repair protein MutS Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11993 BAW_11993 BAB1_2078 XRE family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11994 BAW_11994 BAB1_2079 Protein unknown funcion Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11995 hslU BAB1_2080 ATP-dependent protease ATP-bindingsubunit HslU heat shock protein involved in degradation of misfolded proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11996 hslV BAB1_2081 ATP-dependent protease subunit HslV heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease subunit HslV Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11997 hisB BAB1_2082 imidazoleglycerol-phosphate dehydratase catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11998 BAW_11998 BAB1_2083 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_11999 hisH BAB1_2084 imidazole glycerol phosphate synthase subunit HisH with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamideribonucleotide phosphate and glutamine to imidazole-glycerol phosphate; 5-aminoimidazol-4-carboxamide ribonucleotide; and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12000 BAW_12000 BAB1_2085 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12001 hisF BAB1_2086 imidazole glycerol phosphate synthase subunit HisF catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate; 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12002 hisE BAB1_2087 phosphoribosyl-ATP pyrophosphatase catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidinebiosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12003 coaA BAB1_2088 type I pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12004 BAW_12004 BAB1_2089 peptidyl-tRNA hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12005 pckA BAB1_2090 - BAB1_2091 Pseudogene. Premature stop codon. Similar to BS1330_I2083 and BruAb1_2064; phosphoenolpyruvate carboxykinase (ATP). A pckA mutation in B. abortus 2308 has no effect in Raw 264.7 macrophage intracellular replication and is not attenuated in the mice model Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932;Zuniga-Ripa et al. 2014. J. Bacteriol. 96(16):3045-57
BAW_12006 bvrR BAB1_2092 two-component transcriptional regulator BvrR Brucella virulence related regulatory protein. The two component system BvrRS participates in the homeostasis of the outer membrane (OM) controlling the structure of the lipopolysaccharide (LPS) and the expression of periplasmic and OM proteins (Omp) and controls the expression of the T4SS VirB through direct and indirect mechanisms. BvrRS system is required for intracellular survival and replication. Sola-Landa et al. 1998. Mol Microbiol. 29(1):125-38[82]
BAW_12007 bvrS BAB1_2093 two-component histidine kinase BvrS Brucella virulence related sensory protein. BvrS is a histidine kinase sensor. The two component system BvrRS participates in the homeostasis of the outer membrane (OM) controlling the structure of the lipopolysaccharide (LPS) and the expression of periplasmic and OM proteins (Omp) and controls the expression of the T4SS VirB through direct and indirect mechanisms. BvrRS system is required for intracellular survival and replication Sola-Landa et al. 1998. Mol Microbiol. 29(1):125-38;
BAW_12008 BAW_12008 BAB1_2094 HPr kinase Protein kinase HprK/P phosphorylates NPr on a conserved serine residue; providing an additional level of regulation to the B. melitensis PTS. This kinase activity was inhibited by inorganic phosphate and stimulated by fructose-1;6 bisphosphate. Brucella genomes encoding a truncated homologue of HPr kinase/phosphorylase (HprK/P). In most firmicute HprK/P catalyses the phosphorylation and dephosphorylation of a conserved serine residue in HPr; this system is a central regulator of carbon metabolism mediating among others inducer exclusion and acting as a co-repressor of the catabolite control protein A (CcpA) during CCR. Dozot et al. 2010. PLoS One. 5(9). pii: e12679;
BAW_12009 BAW_12009 BAB1_2095 predicted protein Dozot et al. 2010. PLoS One. 5(9). pii: e12679;
BAW_12010 BAW_12010 BAB1_2096 PTS system fructose subfamily transporter subunit IIA EIIA is part of the enzyme II complex is specific for one or several sugars and is generally; is a cytoplasmic component. Dozot et al. 2010. PLoS One. 5(9). pii: e12679;
BAW_12011 ptsH BAB1_2097 HPr phosphocarrier HPr protein:histidine phosphorylation site in HPr protein Dozot et al. 2010. PLoS One. 5(9). pii: e12679;
BAW_12012 BAW_12012 BAB1_2098 Pseudogene. Frame shift and important deletion near 5’ end; similar to BS1330_I2090 and BruAb1_2071 Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_12013 ahcY BAB1_2099 S-adenosyl-L-homocysteine hydrolase/ Adenosylhomocysteinase catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12014 BAW_12014 BAB1_2100 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12015 BAW_12015 BAB1_2101 two-component sensor histidine kinase Interacts with DivK and CCkA; controls CtrA phosphorylation and proteolysis pathway Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_12016 BAW_12016 BAB1_2102 tRNA threonylcarbamoyladenosine biosynthesis protein TsaE Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12017 BAW_12017 BAB1_2103 mannose-1-phosphate guanylyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12018 addB BAB1_2104 LuxR family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12019 addA BAB1_2105 Double-strand break repair helicase AddA Also named ATP-dependent helicase UvrD/REP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12020 BAW_12020 BAB1_2106 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12021 trx-1 BAB1_2107 thioredoxin Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12022 folC BAB1_2108 folylpolyglutamate synthetase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12023 accD BAB1_2109 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12024 trpA BAB1_2110 tryptophan synthase subunit alpha catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphatein tryptophan biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12025 BAW_12025 BAB1_2111 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12026 trpB BAB1_2112 tryptophan synthase subunit beta catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12027 trpF BAB1_2113 N-(5'-phosphoribosyl)anthranilateisomerase catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12028 BAW_12028 BAB1_2114 Putative YcdF like protein; SAM-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12029 BAW_12029 BAB1_2115 Putative YgjP protein; Predictedmetal-dependent hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12030 BAW_12030 BAB1_2116 - BAB1_2117 Pseudogene; premature stop codon; similar to BS1330_I2108 and BruAb1_2089 Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_12031 BAW_12031 BAB1_2118 - BAB1_2119 Pseudogene. Frame shift; similar to BS1330_I2109 and BruAb1_2090. Benzoate transporter Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_12032 BAW_12032 BAB1_2120 2-hydroxymuconic semialdehyde hydrolase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12033 infC BAB1_2121 translation initiation factor IF-3 IF-3 has several functions that are required and promote translation initiation including;preventingassociation of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12034 BAW_12034 BAB1_2122 isoprenylcysteine carboxyl methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12035 rpmI BAB1_2123 50S ribosomal protein L35 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12036 rplT BAB1_2124 50S ribosomal protein L20 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12037 BAW_12037 BAB1_2125 Mn2+-dependent serine/threonine protein kinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12038 pheS BAB1_2126 phenylalanyl-tRNA synthetase subunit alpha catalyzes a two-step reaction; first charging a phenylalanine molecule by linking its carboxylgroupto the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12039 pheT BAB1_2127 phenylalanyl-tRNA synthetase subunit beta catalyzes a two-step reaction; first charging a phenylalanine molecule by linking its carboxylgroupto the alpha-phosphate of ATP; followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12040 BAW_12040 BAB1_2128 oxidoreductase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12041 dnaK BAB1_2129 Chaperone protein DnaK heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfoldedproteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12042 dnaJ BAB1_2130 chaperone protein DnaJ chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmoticandheat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins; also in an autonomous; dnaK-independent fashion Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12043 BAW_12043 BAB1_2131 SAM-dependent methlyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12044 pyrF BAB1_2132 orotidine 5'-phosphate decarboxylase type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphateto UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12045 BAW_12045 BAB1_2133 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12046 BAW_12046 BAB1_2134 senescence marker protein-30 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12047 gshb BAB1_2135 glutathione synthetase catalyzes the second step in the glutathione biosynthesis pathway; where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12048 BAW_12048 BAB1_2136 Pseudogene. This region contains a frame shift; similar to BS1330_I2126 and BruAb1_2107. Mg chelatase-related protein/ ATPase AAA Brucella suis 1330 genome; accesion number NC_004310;Brucella abortus 9-941 NC_006932
BAW_12049 BAW_12049 BAB1_2137 Putative bacterial transglutaminase-like cysteine proteinase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12050 BAW_12050 BAB1_2138 rare lipoprotein A Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12051 BAW_12051 BAB1_2139 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12052 BAW_12052 BAB1_2140 predicted protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12053 BAW_12053 BAB1_2141 phosphonate ABC transporter substrate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12054 pstC BAB1_2142 phosphate ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12055 pstA BAB1_2143 phosphate ABC transporter permease Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12056 pstB BAB1_2144 phosphate ABC transporter ATP-binding protein ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12057 phoU BAB1_2145 PhoU family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12058 phoB BAB1_2146 response regulator interacting with PhoR histidine kinase also named chemotaxis protein CheY Hallez et al. 2007. EMBO J. 26(5):1444-55;
BAW_12059 BAW_12059 BAB1_2147 cell wall hydrolase SleB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12060 BAW_12060 BAB1_2148 putative lipoprotein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12061 pepS BAB1_2149 peptidase M29 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12062 dps BAB1_2150 DNA starvation/stationary phase protection protein Dps binds DNA in a non-sequence-specific manner and is abundant during stationary phase; formsa DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage Roop et al. 2012. Metal acquistion by Brucella strains; pp. 179-199. In O' Callaghan; D.; and Lopez-Goni; I. (eds.) Brucella: Molecular Microbiology and Genomics[83]
BAW_12063 BAW_12063 BAB1_2151 tRNA threonylcarbamoyladenosine biosynthesis protein TsaB Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12064 BAW_12064 BAB1_2152 ribosomal-protein-alanine acetyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12065 OlsA BAB1_2153 OlsA Lyso-ornithine O-acyltransferase catalizes the second step in the synthesis of Ornithine lipid Palacios-Chaves. 2011. PLoS One. 6(1):e16030;
BAW_12066 BAW_12066 BAB1_2154 (dimethylallyl)adenosine tRNA methylthiotransferase catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37intRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12067 phoH BAB1_2155 phosphate starvation protein PhoH Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12068 BAW_12068 BAB1_2156 16S rRNA maturation RNase YbeY Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12069 BAW_12069 BAB1_2157 CBS/transport-associated domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12070 lnt BAB1_2158 apolipoprotein N-acyltransferase Transfers the fatty acyl group on membrane lipoproteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12071 BAW_12071 BAB1_2159 Cro/Cl family transcriptional regulator helix-hairpin-helix DNA-binding domain-containing protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12072 BAW_12072 BAB1_2160 S-adenosylmethionine synthetase catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12073 trmB BAB1_2161 tRNA (guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46(m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12074 rimP BAB1_2162 Ribosome maturation factor RimP in Streptococcus pneumoniae this gene was found to be essential; structure determination oftheStreptococcus protein shows that it is similar to a number of other proteins Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12075 nusA BAB1_2163 transcription termination factor NusA modifies transcription through interactions with RNA polymerase affecting elongation; readthrough;termination; and antitermination Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12076 BAW_12076 BAB1_2164 Putative DNA-binding protein DNA-binding protein in other proteobacteria species Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12077 infB BAB1_2165 translation initiation factor IF-2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12078 rbfA BAB1_2166 ribosome-binding factor A associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; inEscherichia coli rbfA is induced by cold shock Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12079 truB BAB1_2167 tRNA pseudouridine synthase B catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residuesin Tloops of many tRNAs Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12080 rpsO BAB1_2168 30S ribosomal protein S15 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and anintersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12081 BAW_12081 BAB1_2169 polynucleotide phosphorylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12082 BAW_12082 BAB1_2170 16S rRNA methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12083 BAW_12083 BAB1_2171 methyltransferase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12084 fabI-2 BAB1_2172 Enoyl-[acyl-carrier-protein] reductase [NADH] Catalyzes a key regulatory step in fatty acid biosynthesis Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12085 fabB BAB1_2173 3-oxoacyl-ACP synthase FabB; beta-Ketoacyl-ACP synthase I; KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12086 fabA BAB1_2174 3-hydroxydecanoyl-ACP dehydratase catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2;3-decenoyl-ACP or 3;4-decenoyl-ACP Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12087 irr BAB1_2175 Fur family transcriptional regulator Iron response regulator Martinez et al. 2005. Microbiology 151:3427-3433[84]
BAW_12088 BAW_12088 BAB1_2176 metal ABC transporter substrate-binding protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12089 BAW_12089 BAB1_2177 Bacterial SH3-like region Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12090 BAW_12090 BAB1_2178 D-glycerate dehydrogenase Previously named TrkA potassium uptake protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12091 BAW_12091 BAB1_2179 esterase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12092 BAW_12092 BAB1_2180 peptidase P60 Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12093 BAW_12093 BAB1_2181 MarR family transcriptional regulator Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12094 BAW_12094 BAB1_2182 cytochrome C oxidase subunit II Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12095 BAW_12095 BAB1_2183 pilus biosynthesis protein-like protein Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12096 BAW_12096 BAB1_2184 formamidopyrimidine-DNA glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12097 BAW_12097 BAB1_2185 enoyl-CoA hydratase Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_12098 rpsT BAB1_2186 30S ribosomal protein S20 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginineandornithine decarboxylase Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1rRNA01 BAW_1rRNA01 BAB1_2229 5S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1rRNA02 BAW_1rRNA02 BAB1_2230 23S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1rRNA03 BAW_1rRNA03 BAB1_2233 16S ribosomal RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tmRNA0001 ssrA BAB1_2214 Transfer-messenger RNA Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA01 BAW_1tRNA01 BAB1_2187 tRNA-Ala Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA02 BAW_1tRNA02 BAB1_2189 tRNA-Pro Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA03 BAW_1tRNA03 BAB1_2190 tRNA-Phe Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA04 BAW_1tRNA04 BAB1_2191 tRNA-Thr Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA05 BAW_1tRNA05 BAB1_2192 tRNA-Arg Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA06 BAW_1tRNA06 BAB1_2193 tRNA-Gln Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA07 BAW_1tRNA07 BAB1_2194 tRNA-Ser Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA08 BAW_1tRNA08 BAB1_2195 tRNA-Pro Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA09 BAW_1tRNA09 BAB1_2196 tRNA-Arg Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA10 BAW_1tRNA10 BAB1_2197 tRNA-Pro Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA11 BAW_1tRNA11 BAB1_2198 tRNA-Val Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA12 BAW_1tRNA12 BAB1_2199 tRNA-Asp Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA13 BAW_1tRNA13 BAB1_2202 tRNA-Val Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA14 BAW_1tRNA14 BAB1_2203 tRNA-Arg Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA15 BAW_1tRNA15 BAB1_2204 tRNA-Gly Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA16 BAW_1tRNA16 BAB1_2205 tRNA-Leu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA17 BAW_1tRNA17 BAB1_2206 tRNA-Leu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA18 BAW_1tRNA18 BAB1_2207 tRNA-Leu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA19 BAW_1tRNA19 BAB1_2208 tRNA-Trp Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA20 BAW_1tRNA20 BAB1_2209 tRNA-Gly Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA21 BAW_1tRNA21 BAB1_2210 tRNA-Tyr Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA22 BAW_1tRNA22 BAB1_2211 tRNA-Glu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA23 BAW_1tRNA23 BAB1_2212 tRNA-Glu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA24 BAW_1tRNA24 BAB1_2213 tRNA-Lys Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA25 BAW_1tRNA25 BAB1_2216 tRNA-Met Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA26 BAW_1tRNA26 BAB1_2217 tRNA-Met Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA27 BAW_1tRNA27 BAB1_2218 tRNA-His Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA28 BAW_1tRNA28 BAB1_2219 tRNA-Gln Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA29 BAW_1tRNA29 BAB1_2220 tRNA-Met Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA30 BAW_1tRNA30 BAB1_2226 tRNA-Glu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA31 BAW_1tRNA31 BAB1_2227 tRNA-Ser Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA32 BAW_1tRNA32 BAB1_2228 tRNA-Met Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA33 BAW_1tRNA33 BAB1_2231 tRNA-Ala Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA34 BAW_1tRNA34 BAB1_2232 tRNA-Ile Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA35 BAW_1tRNA35 BAB1_2234 tRNA-Leu Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA36 BAW_1tRNA36 BAB1_2235 tRNA-Ala Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618
BAW_1tRNA37 BAW_1tRNA37 BAB1_2236 tRNA-Arg Chain et al. 2005. Infect Immun. 73:8353-61;Brucella abortus 2308; accesion number NC_007618

References[edit]

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