Brushfield spots are small, white or grayish/brown spots on the periphery of the iris in the human eye due to aggregation of connective tissue, a normal iris element. The spots are named after the physician Thomas Brushfield, who first described them in his 1924 M.D. thesis.
These spots are normal in children (Kunkmann-Wolffian bodies), but are also a feature of the chromosomal disorder Down syndrome. They occur in 35–78% of newborn infants with Down syndrome. They are much more likely to occur in children with Down syndrome of European descent than children of Asian heritage with Down's Syndrome.
- Wallis, Hugh R.E. "The Significance of Brushfield's Spots in the Diagnosis of Mongolism in Infancy", Archives of Disease in Childhood, 1951 December; 26 (130): 495-500. Retrieved on 21 March 2009.
- Sanez, R.B. (January 1999), "Primary care of infants and young children with Down syndrome", American Family Physician 59 (2)
- Kim, J.H.; et al. (November 2002), "Characteristic ocular findings in Asian children with Down syndrome", Nature 16 (6)
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