Buclizine

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Buclizine
Buclizine.svg
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
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UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.317 Edit this at Wikidata
Chemical and physical data
FormulaC28H33ClN2
Molar mass433.028 g/mol g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
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Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]

References[edit]

  1. ^ Mostafa GA, Al-Badr AA (2011). "Buclizine". Profiles Drug Subst Excip Relat Methodol. Profiles of Drug Substances, Excipients and Related Methodology. 36: 1–33. doi:10.1016/B978-0-12-387667-6.00001-4. ISBN 9780123876676. PMID 22469258.
  2. ^ Behrendt WA, Cserepes J (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica. 4 (5): 322–31. PMID 4070325.