Buddleja americana is the most widespread of all the Buddleja species native to the Americas, its range extending south from Tamaulipas, Mexico, through Central America and much of the West Indies into South America, reaching eastward to Venezuela, westward as far as the Galapagos, and south to Bolivia. It occurs at elevations from sea level to 2500 m, in a variety of habitats, including cloud forest, mountain savanna, pine - oak forest, and rocky slopes near rivers. It also invades fields and roadsides.
B. americana is a trioecious shrub, 2–5 m tall with light brown fissured bark. The young branches are subquadrangular, and tomentose, bearing leaves which vary greatly in size, shape and indumentum. The inflorescences are 5–25 cm long, with one or two orders of branches. The flowers are borne in cymules, the short (< 2.5 mm) corollas yellow inside and white outside. As with the other American species of Buddleja, B. americana is tetraploid (2n = 76).
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