Buflomedil

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Buflomedil
Buflomedil.svg
Names
IUPAC name
4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.054.393
UNII
Properties
C17H25NO4
Molar mass 307.38 g/mol
Pharmacology
C04AX20 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. It is currently not approved by the Food and Drug Administration (FDA) for use in the United States. Currently available as trade name tablet Loftyl

Toxicity[edit]

This drug might be suspended from marketing in the European Union, because of concerns about severe neurological and cardiac toxicity.[1][2] In its press release dated 17 November 2011 EMA suggested that doctors "should stop using buflomedil and consider alternative treatment options".

Various adverse effects have been reported to the FDA.[3]

References[edit]