Bullous impetigo

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Bullous impetigo
Bullous impetigo1.jpg
Bullous impetigo after rupture of the bullae

Bullous Impetigo is a skin condition that characteristically occurs in the newborn, and is caused by a bacterial infection, presenting with bullae.[1]:256

It can be caused by Exfoliative toxin A.[2] The phyogenic superficial infection can be divided into two other subdivisions; Impetigo, and non-bullous impetigo. Bullous impetigo is caused by Staphylococcus aureus, which produces exfoliative toxins, whereas non-bullous impetigo is caused by either Staphylococcus aureus, or Streptococcus pyogenes.[3] Thirty percent of all Impetigo cases are related to Bullous impetigo. Bullous impetigo, in newborns, children, or adults who are immunocompromised and/or are experiencing renal failure, can develop into a more severe and generalized form called Staphylococcal scalded skin syndrome (SSSS). The mortality rate is less than 3% for infected children, but up to 60% in adults.[4]

Signs and symptoms[edit]

Bullous impetigo on the arm
Bullous impetigo

Bullous impetigo can appear around the diaper region, axilla, or neck. The bacteria causes a toxin to be produced that reduces cell-to-cell stickiness (adhesion), causing for the top layer of skin (epidermis), and lower layer of skin (dermis) to separate. Vesicles rapidly enlarge and form the bullae which is a blister more than 5mm across. Bullae is also known as Staphylococcal scalded skin syndrome. Other associated symptoms are itching, swelling of nearby glands, fever and diarrhea. It should also be noted that pain is very rare.

Long-term effects: once the scabs on the bullous have fallen off, scarring is minimal. Possible long-term effects are kidney disease.


Exposure is most commonly seen in hospital wards and nurseries, and can be passed from person to person in other settings, such as close contact sports. Therefore, the patient is advised to try to limit human contact as much as possible to minimize the risk of spreading the infection.[5]

Infectious period[edit]

After 48 hours the disease is considered no longer contagious assuming the proper antibiotic treatments have been administered.


Exfoliating toxins are serine proteases that specifically bind to and cleave desmoglein 1 (Dsg1). Previous studies suggested that exfoliating toxins bind to gangliosides, causing a release of protease by keratinocytes acting as superantigens in stimulating the skin’s immune system.[4] A more recent proposal states there are three known exfoliating toxins; ETA, ETB, and ETD which act as a glutamic acid-specific serine protease with concentrated specificity. Which results in the cleavage of human Dsg1 at a unique site after glutamic acid residues causing deactivation.[4] Proteolysis of the peptide bond leading up to the dysfunction of Dsg1 and the desmosome allows for an understanding as to why the bullous forms, making the peptide bond crucial for proper function if Dsg1.

S. aureus[edit]

A phyogenic non-motile Gram-positive cocci which forms into grape like clusters. Just like other forms of staph, S. aureus has a variety of virulence factors which include surface proteins involved in adherence, secretion of enzymes that degrade proteins, and secrete toxins which damage the host’s cells.

S. aureus expresses surface receptors for fibrinogen, fibronectin, and vitronectin. These surface receptors allow a bridge to be formed which binds to host endothelial cells. Lipases allow for the degradation of lipids on the skin surface and its expression can be directly correlated with its ability of the bacteria to produce abscesses.[6]


Observing the skin's physical appearance, or swabbing a culture of the lesion for S. aureus. Nasal swabs from the patient’s immediate family members are necessary to identify them as being asymptomatic nasal carriers of S. aureus.


The epidermis is composed of four layers, Stratum basale, Stratum spinosum, Stratum granulosum, and Stratum corneum.[7][7]

Normal H&E
H&E of Bullous Impetigo

The cleavage plane can be found either subcorneally or within the upper stratum granulosum. The roof of the pustule is parakeratotic stratum corneum, and the floor is formed of keratinocytes, which may or may not be acantholytic.[8] Neutrophils begin to fill the pustule. Toxins are produced by S. aureus and target desmoglein, which is a desmosomal cell-cell adhesion molecule found in the upper levels of the epidermis. This correlates with the subcorneal localization of the bullae.[8]

Uncommon variants[edit]


  • HPV
  • insect bites
  • burns
  • Herpes simplex 1/2


Since the common pathogens involved with impetigo are bacteria naturally found on the skin, most prevention (especially in children), is targeted towards appropriate hygiene, wound cleaning, and minimizing scratching (i.e. by keeping nails trimmed and short). Avoiding close contact and sharing of items such as towels with potentially infected individuals is also recommended.


Antibiotic creams are the preferred treatment for mild cases of impetigo, despite their limited systemic absorption. Such prescribed ointments include neosporin, fusidic acid, chloramphenicol and mupirocin. More severe cases of impetigo however (especially bullous impetigo) will likely require oral agents with better systemic bioavailability, such as cephalexin. Cases that do not resolve with initial antibiotic therapy or require hospitalization may also be indicative an MRSA infection, which would require the use of agents specifically able to treat it, such as clindamycin.

Antibiotic treatment typically last 7–10 days, and although highly effective some cases of methicillin resistant S. aureus (MRSA) may require longer therapy depending on the severity of infection and how much it has spread.

See also[edit]


  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  2. ^ Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR (November 2000). "Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1". Nat. Med. 6 (11): 1275–7. doi:10.1038/81385. PMID 11062541.
  3. ^ Bullous impetigo. (2005). Retrieved from http://www.impetigodoctor.com/bullous-impetigo.htm
  4. ^ a b c Yasushi, Hanakawa. "Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome." journal of Clinical Investigation. 110.1 (2002): 53-60.
  5. ^ Lucky, A. (2009, November 9). Blistering disorders in infancy. Retrieved from http://www.docstoc.com/docs/15402241/Blistering-Disorders-in-Infancy
  6. ^ 7)Kumar, V, A Abbas, and N Fausto. "Pathologic Basis of Disease." 7th. Chicago: Robbins and Cotran, 2004. 620
  7. ^ a b 5) Roy, S. (2009). Histology of the normal skin. Retrieved from http://www.histopathology-india.net/NH.htm
  8. ^ a b 8) Carter, D, J Greenson, H Oberman, V Reuter, and StolerM. “Sternberg’s Diagnostic Surgical Pathology." 4th. 1. New York City: Lippincott Williams & Wilkins , 2004. 17f

External links[edit]