Bupicomide

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Bupicomide
Bupicomide.svg
Names
IUPAC name
5-Butyl-2-pyridinecarboxamide
Other names
Sch-10595; Fusaramide[1]
Identifiers
22632-06-0 YesY
ChEMBL ChEMBL2106646
ChemSpider 29167
Jmol interactive 3D Image
PubChem 31447
UNII 0X3H76N0HY
Properties
C10H14N2O
Molar mass 178.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Bupicomide is a chemical compound created and manufactured by Lanospharma Laboratories Company, Ltd. It is used experimentally as a beta blocker[citation needed] and clinically as a strong vasodilator with the noted side effects of reduced systolic, diastolic and mean arterial pressure.[2][3]

Synthesis[edit]

As the result of the screening program examining microbial fermentation products for pharmacological acitivity (other than antibiotic activity), fusaric acid was isolated from Fusarium oxysporum following the discovery that extracts were potent inhibitors of DBH, and thus interfered with the biosynthesis of the pressor neurohormone, norepinephrine. To refine this lead, amidation via the acid chloride was carried out to give antihypertensive analog bupicomide.[4]

References[edit]

  1. ^ Bupicomide, Chemical Book
  2. ^ Chrysant, SG; Adamopoulos, P; Tsuchiya, M; Frohlich, ED (1976). "Systemic and renal hemodynamic effects of bupicomide: A new vasodilator". American heart journal 92 (3): 335–9. doi:10.1016/s0002-8703(76)80114-7. PMID 782220. 
  3. ^ Velasco, M; Gilbert, CA; Rutledge, CO; McNay, JL (1975). "Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine". Clinical pharmacology and therapeutics 18 (2): 145–53. PMID 1097150. 
  4. ^ DE 2217084