Bupicomide

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Bupicomide
Bupicomide.svg
Names
IUPAC name
5-Butyl-2-pyridinecarboxamide
Other names
Sch-10595; Fusaramide[1]
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.041.024
UNII
Properties
C10H14N2O
Molar mass 178.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Bupicomide is a chemical compound created and manufactured by Lanospharma Laboratories Company, Ltd. It is used experimentally as a beta blocker[citation needed] and clinically as a strong vasodilator with the noted side effects of reduced systolic, diastolic and mean arterial pressure.[2][3]

Synthesis[edit]

As the result of the screening program examining microbial fermentation products for pharmacological acitivity (other than antibiotic activity), fusaric acid was isolated from Fusarium oxysporum following the discovery that extracts were potent inhibitors of DBH, and thus interfered with the biosynthesis of the pressor neurohormone, norepinephrine. To refine this lead, amidation via the acid chloride was carried out to give antihypertensive analog bupicomide.[4]

References[edit]

  1. ^ Bupicomide, Chemical Book
  2. ^ Chrysant, SG; Adamopoulos, P; Tsuchiya, M; Frohlich, ED (1976). "Systemic and renal hemodynamic effects of bupicomide: A new vasodilator". American Heart Journal. 92 (3): 335–9. doi:10.1016/s0002-8703(76)80114-7. PMID 782220. 
  3. ^ Velasco, M; Gilbert, CA; Rutledge, CO; McNay, JL (1975). "Antihypertensive effect of a dopamine beta hydroxylase inhibitor, bupicomide: A comparison with hydralazine". Clinical pharmacology and therapeutics. 18 (2): 145–53. PMID 1097150. 
  4. ^ DE 2217084