|Chemical and physical data|
|Molar mass||144.1 kDa g·mol−1|
Burosumab (INN, trade name Crysvita) known as KRN23 is a human monoclonal antibody designed for the treatment of X-linked hypophosphatemia. Burosumab was approved by the FDA for its intended purpose, in patients aged 1 year and older, on 17 April 2018. The FDA approval fell under both the breakthrough therapy and orphan drug designations.
This drug was developed by Ultragenyx and is in a collaborative license agreement with Kyowa Hakko Kirin.
While burosumab is effective for the treatment of X-linked hypophosphatemia, the UK National Institute for Health and Care Excellence has raised concerns regarding the incremental cost-effectiveness of the new treatment.
- Statement On A Nonproprietary Name Adopted By The USAN Council - Burosumab, American Medical Association.[permanent dead link]
- World Health Organization (2016). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 115" (PDF). WHO Drug Information. 30 (2): 255.
- "Burosumab (KRN23) for X-Linked Hypophosphatemia (XLH)" (PDF). n.d. Retrieved 2018-04-18.
- "FDA approves first therapy for rare inherited form of rickets, x-linked hypophosphatemia" (Press release). FDA. 17 April 2018.
- "Collaboration with Ultragenyx to Develop and Commercialize KRN23 for X-linked Hypophosphatemia" (Press release). Kyowa Kirin. 4 September 2013. Retrieved 2018-04-17.
- "U.K. cost watchdogs turn away rare disease med Crysvita".
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