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Systematic (IUPAC) name
2-(2-diethylaminoethoxy)ethyl 2-phenylbutanoate
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Protein binding 98%
Biological half-life 6 hours
Excretion 90% renal
CAS Number 18109-80-3 YesY
ATC code R05DB13 (WHO)
PubChem CID 28892
ChemSpider 26873 YesY
UNII M75MZG2236 YesY
KEGG D07594 YesY
Chemical data
Formula C18H29NO3
Molar mass 307.428 g/mol

Butamirate (or brospamin) is a cough suppressant.[1]

A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.[2]

As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)


  1. ^ Germouty, J.; Weibel, M. A. (1990). "Clinical comparison of butamirate citrate with a codeine-based antitussive agent". Revue medicale de la Suisse romande. 110 (11): 983–986. PMID 1980027. 
  2. ^ Klein, M.; Musacchio, J. M. (1989). "High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents". The Journal of Pharmacology and Experimental Therapeutics. 251 (1): 207–215. PMID 2477524.