BzODZ-EPyr

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BzODZ-EPyr
BzODZ-EPyr.svg
Legal status
Legal status
Identifiers
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC23H24N4O
Molar mass372.472 g·mol−1
3D model (JSmol)

BzODZ-EPyr is an indole based synthetic cannabinoid that has been sold as a designer drug in Russia.[1]

It acts as a CB1 receptor agonist with a pKB value of 7.2 and demonstrates that replacing the ketone in 3-carbonylindoles with an oxadiazole spacer does generally not lead to activity loss.[2][3]

See also[edit]

References[edit]

  1. ^ Shevyrin, Vadim; Melkozerov, Vladimir; Eltsov, Oleg; Shafran, Yuri; Morzherin, Yuri (February 2016). "Synthetic cannabinoid 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole. The first detection in illicit market of new psychoactive substances". Forensic Science International. 259: 95–100. doi:10.1016/j.forsciint.2015.12.019. PMID 26771874.
  2. ^ Moloney, Gerard P.; Angus, James A.; Robertson, Alan D.; Stoermer, Martin J.; Robinson, Michael; Wright, Christine E.; McRae, Ken; Christopoulos, Arthur (March 2008). "Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor". European Journal of Medicinal Chemistry. 43 (3): 513–539. doi:10.1016/j.ejmech.2007.04.007. PMID 17582659.
  3. ^ Moloney, Peter Gerard; Robertson, Alan Duncan (2005), "Patent US6930118 - 3-Oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives", Amrad Operations Pty. Ltd.