The first issued stamp she engraved was for Monaco in 1967 and represented a Cooper-Climax car that won the Grand Prix of Monaco. It was originally designed by Pierrette Lambert. Her first stamp for France was issued in 1973 and represented the Clos Lucé in Amboise.
When she retired in 1993, she had engraved or designed more than three hundred stamps for France, French post offices in Andorra, Monaco, and French Overseas territories, as well as some African French-speaking countries.
Cécile Guillame also created print and ceramics.
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