Carbon–hydrogen bond activation

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General scheme for C-H functionalization

Carbon–hydrogen bond functionalization (C–H functionalization) is a type of reaction in which a carbon–hydrogen bond is cleaved and replaced with a carbon-X bond (where X is usually carbon, oxygen, or nitrogen). The term usually implies that a transition metal is involved in the C-H cleavage process.[1][2] Reactions classified by the term typically involve the hydrocarbon first to react with a metal catalyst to create an organometallic complex in which the hydrocarbon is coordinated to the inner-sphere of a metal, either via an intermediate "alkane or arene complex" or as a transition state leading to a "M−C" intermediate.[3][4][5] The intermediate of this first step (known as C-H activation and sometimes used interchangeably with C-H functionalization) can then undergo subsequent reactions to produce the functionalized product. Important to this definition is the requirement that during the C–H cleavage event, the hydrocarbyl species remains associated in the inner-sphere and under the influence of "M".

Some mechanisms for C-H activation

Mechanisms for C-H activations fall under three general categories: (i) oxidative addition, in which a metal center inserts into a carbon-hydrogen bond, which cleaves the bond and oxidizes the metal, producing an intermediate that can undergo reductive elimination to yield the organometallic reactive intermediate (ii) electrophilic activation, which reacts similarly to oxidative addition, but differs in that it produces the organometallic reactive intermediate through an "oxidative" transition state instead of an intermediate, and (iii) Sigma-bond metathesis, which proceeds through a "four-centered" transition state in which bonds break and form in a single step: the target hydrocarbon bond breaks as the carbon bonds to the metal and the hydrogen bonds to one of the metal’s ligands, which causes bond breakage between the ligand and the metal.

C–H bonds, which are traditionally considered unreactive, can be cleaved by coordination. Much research has been devoted to the design and synthesis of new reagents and catalysts that can effect C–H activation. C-H activation chemistry has the potential to transform the chemical world through the development of novel synthetic methods. C-H activation could enable the conversion of cheap and abundant alkanes into valuable functionalized organic compounds and the efficient structural editing of already complex molecules (i.e. natural product synthesis).[6] Selective activation of a specific C-H bond poses a great challenge. In addition to a high bond dissociation energy, C-H bonds have very low polarity because to these two elements have similar electronegativities.

Historic overview[edit]

The first C–H activation reaction is often attributed to Otto Dimroth, who in 1902, reported that benzene reacted with mercury(II) acetate (See: organomercury), but some scholars[who?] do not view this reaction as being true C–H activation. Many electrophilic metal centers undergo this reaction. Joseph Chatt has been credited by many to be the first to perform the first C-H activation reaction in 1965[7] with the insertion of ruthenium, in the form of RuCl2(dmpe)2 (where dmpe = 1,2-Bis(dimethylphosphino)ethane), into the C-H bond of naphthalene. However, in 1955,[8] Shunsuke Murahashi reported a cobalt-catalyzed chelation-assisted C-H functionalization of 2-phenylisoindolin-1-one from (E)-N,1-diphenylmethanimine.

Cobalt-catalyzed C-H activation

In 1969, A.E. Shilov reported that potassium tetrachloroplatinate induced isotope scrambling between methane and heavy water. The pathway was proposed to involve binding of methane to Pt(II). In 1972, the Shilov group was able to produce methanol and methyl chloride in a similar reaction involving a stoichiometric amount of potassium tetrachloroplatinate, catalytic potassium hexachloroplatinate, methane and water. Due to the fact that Shilov worked and published in the Soviet Union during the Cold War era, his work was largely ignored by Western scientists. This so-called Shilov system is today one of the few true catalytic systems for alkane functionalizations.[3]

In some cases, discoveries in C-H activation were being made in conjunction with those of cross coupling. In 1969,[9] Yuzo Fujiwara reported the synthesis of (E)-1,2-diphenylethene from benzene and styrene with Pd(OAc)2 and Cu(OAc)2, a procedure very similar to that of cross coupling. On the category of oxidative addition, M. L. H. Green in 1970 reported on the photochemical insertion of tungsten (as a Cp2WH2 complex) in a benzene C–H bond[10] and George M. Whitesides in 1979 was the first to carry out an intramolecular aliphatic C–H activation[11]

Fujiwara's palladium- and copper-catalyzed C-H functionalization

The next breakthrough was reported independently by two research groups in 1982. R. G. Bergman reported the first transition metal-mediated intermolecular C–H activation of unactivated and completely saturated hydrocarbons by oxidative addition. Using a photochemical approach, photolysis of Cp*Ir(PMe3)H2, where Cp* is a pentamethylcyclopentadienyl ligand, led to the coordinatively unsaturated species Cp*Ir(PMe3) which reacted via oxidative addition with cyclohexane and neopentane to form the corresponding hydridoalkyl complexes, Cp*Ir(PMe3)HR, where R = cyclohexyl and neopentyl, respectively.[12] W.A.G. Graham found that the same hydrocarbons react with Cp*Ir(CO)2 upon irradiation to afford the related alkylhydrido complexes Cp*Ir(CO)HR, where R = cyclohexyl and neopentyl, respectively.[13] In the latter example, the reaction is presumed to proceed via the oxidative addition of alkane to a 16-electron iridium(I) intermediate, Cp*Ir(CO), formed by irradiation of Cp*Ir(CO)2.

C–H activation by Bergman et al. (left) and Graham et al.

The selective activation and functionalization of alkane C–H bonds was reported using a tungsten complex outfitted with pentamethylcyclopentadienyl, nitrosyl, allyl and neopentyl ligands, Cp*W(NO)(η3-allyl)(CH2CMe3).[14]

C–H activation of pentane, as seen in Ledgzdins et al., J. Am. Chem. Soc. 2007; 129, 5372–3.

In one example involving this system, the alkane pentane is selectively converted to the halocarbon 1-iodopentane. This transformation was achieved via the thermoloysis of Cp*W(NO)(η3-allyl)(CH2CMe3) in pentane at room temperature, resulting in elimination of neopentane by a pseudo-first-order process, generating an undetectable electronically and sterically unsaturated 16-electron intermediate that is coordinated by an η2-butadiene ligand. Subsequent intermolecular activation of a pentane solvent molecule then yields an 18-electron complex possessing an n-pentyl ligand. In a separate step, reaction with iodine at −60 °C liberates 1-iodopentane from the complex.

Arene C–H bonds are readily activated by metal complexes, as illustrated by directed ortho metalation. N,N-dimethylbenzylamine in a cyclometalation readily by many transition metals:[15]

Cyclometallation with a Substituted Benzylamine Chetcuti 2007
One manifestation is the Murai olefin coupling.[16]

Scope[edit]

Overview[edit]

Two pathways achieve C-H activation: innate C-H activation or guided C-H activation. The figure depicts the two oxidation products possible, depending on the reagents used to functionalize a specific C-H bond.[17]

Guided vs. Innate C-H Activation

Selectivity of C-H activation[edit]

Among the various factors that affect selectivity in C-H activation, the more sterically accessible C-H bond will have more selectivity at that position.

Selective C-H activation due to strain release

In the figure above, the axial C-H bond in cis-1,2-dimethylcyclohexane is selectively oxidized over the equatorial C-H bond. During oxidation, the axial methyl group becomes planar, decreasing the 1,3-diaxial interactions in the transition state, which stabilizes the transition state.[18]

An alkene C–H bond activation with a rhodium catalyst is demonstrated in the synthesis of this strained bicyclic enamine:[19]

C–H bond activation Yotphan 2008

Innate selectivity[edit]

Innate selectivity is observed for reactions that functionalize C-H bonds that lack an influence of directing forces, thus only relying on the natural reactivity of the molecule.[17] Inductive (through-bond) effects can explain the innate selectivity of a C-H bond in a molecule through the examination of the electronic nature of the bonds. The presence and proximity of electron-withdrawing groups (EWGs) or electron-donating groups (EDGs) can heavily influence the electron density of a C-H bond.[20] The reactivity trend for nonmetal insertion is tertiary>secondary>primary.[21] Steric effects can also influence the selectivity of C-H bond activation: bulky groups can decrease the rate of functionalizing an adjacent C-H bond.

Influence of inductive effects on selectivity of C-H bond activation

For oxaziridine (left), the 1st site is oxidized preferably due not only to distance from the electron-withdrawing OBz group but also because of its substitution—the carbon is tertiary—and so it is more electron rich. Similarly, the secondary methylene position in trifluoromethyldioxirane (TFDO, right) that is farthest away to the electron-withdrawing group is selectively oxidized.[20] Note that here, like with oxaziridine, substitution at the carbon also greatly affects selectivity; the secondary methylene position is preferred over the terminal methylene position because the former has a secondary carbon while the latter has a primary one.

Steric Effects

In the oxidation of cyclohexane compound, the tertiary site on the ring is preferential over the tertiary site of the isopropyl substituent. The two methyl groups hinder the oxidation on the isopropyl group, making the less hindered cyclohexyl site more favorable.[20]

Guided selectivity[edit]

In contrast to innate selectivity, guided selectivity results from external reagents or directing groups affecting the nature of specific C-H bonds.[17]

Guided Example 1

The figure above demonstrates the use of a pyridine directing group to activate selectively a C-H bond to form a C-halogen bond. Pyridine derivatives are commonly used for ortho-selective C-H functionalization. Such reactions use metals like palladium to catalyze sp2 C-H activation. A similar system uses pyridine to acetoxylate the C-H bond, forming a C-OAc bond, instead of a C-X halogen bond.[2]

Pd-catalyzed C-H activation reaction

The mechanism for the pyridine based Pd-catalyzed C-H activation reactions involves a catalytic cycle in which the ligand directs the molecule to interact with Pd to form a metallacycle intermediate. The intermediate is oxidized to form a PdIV species, followed by reductive elimination to form the C-O bond and release the product.[2]

Pd-catalyzed mechanism for C-H activation

See Meta-selective C-H functionalization for more examples of directed C-H activation.

Reaction conditions[edit]

Many C–H bond activations proceed under rather harsh reaction conditions (high temperature, strongly acidic or basic conditions, strong oxidant, etc.), significantly limiting their utility. However, mild methods have been developed, significantly expanding the scope of these transformations.[22] Organocatalysis is another important approach to facilitating C-H activation.[23]

Case Study: Borylation[edit]

Transforming C-H bonds into C-B bonds through borylation has been thoroughly investigated due to their utility in synthesis (i.e. for cross-coupling reactions). J.F. Hartwig reported a highly regioselective arene and alkane borylation catalyzed by a rhodium complex. In the case of alkanes, exclusive terminal functionalization was observed.[24]

Hartwig borylation

Later, ruthenium catalysts were discovered to have higher activity and functional group compatibility.[25]

Ru catalyst based borylation

Other borylation catalysts have also been developed, including iridium-based catalysts, which successfully activate C-H bonds with high compatibility.[26][27][28]

For more information, consult borylation.

Applications[edit]

No applications have been commercialized for homogeneously catalyzed C-H activations.

Natural gas[edit]

Naturally occurring methane is not utilized as a chemical feedstock, despite its abundance and low cost. Current technology makes prodigious use of methane by steam reforming to produce syngas, a mixture of carbon monoxide and hydrogen. This syngas is then used in Fischer-Tropsch reactions to make longer carbon chain products or methanol, one of the most important industrial chemical feedstocks.[29][30] An intriguing methods to convert these hydrocarbons involves C-H activation. Periana, for example, reported that complexes containing late transition metals, such as Pt, Pd, Au, and Hg, react with methane (CH4) in H2SO4 to yield methyl bisulfate.[31][32] The process has not however been implemented commercially.

C–H Bond Activation Periana 1998

Natural product synthesis[edit]

The development of methodology for C-H activation has significantly impacted natural product synthesis, at least in the academic realm. Ideally, synthetic routes contain minimal steps, while maximizing yield. C-H activation has enabled researchers to activate C-H bonds in highly functionalized molecules.[33]

Example of synthesis of core leading to multiple natural products

The product in the above reaction is a common scaffold for multiple natural products, including hapalindole Q and ambiguine H. The core structure can be made through a C-C bond (blue bond in product) formation via C-H activation. The innate reactivity of the indole and enolate leads to the formation of the C-C bond to form the indole-carvone intermediate.[17]

(+)-Lithospermic acid via C-H activation[edit]

The total synthesis of lithospermic acid employs guided C-H functionalization late stage to a highly functionalized system. The directing group, a chiral nonracemic imine, is capable of performing an intramolecular alkylation, which allows for the rhodium-catalyzed conversion of imine to the dihydrobenzofuran.[34]

Key step in synthesis of lithospermic acid

Calothrixin A and B via C-H activation[edit]

The total synthesis of calothrixin A and B features an intramolecular Pd-catalyzed cross coupling reaction via C-H activation, an example of a guided C-H activation. Cross coupling occurs between aryl C-I and C-H bonds to form a C-C bond (highlighted in red).[35]

Key step in total synthesis of Calothrixin A and B

Mescaline analogue via C-H activation[edit]

The synthesis of a Mescaline analogue, which has interesting biological properties, employs, specifically, the rhodium-catalyzed enantioselective annulation of an aryl imine via a C-H activation.[36]

Mescalineprep.jpg

See also[edit]

Additional Sources[edit]

References[edit]

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