C-fos-induced growth factor

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FIGF
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FIGF, VEGF-D, VEGFD, C-fos induced growth factor, c-fos induced growth factor (vascular endothelial growth factor D)
External IDs MGI: 108037 HomoloGene: 3288 GeneCards: FIGF
RNA expression pattern
PBB GE FIGF 206742 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004469

NM_010216
NM_001308489

RefSeq (protein)

NP_004460.1

NP_001295418.1
NP_034346.1

Location (UCSC) Chr X: 15.35 – 15.38 Mb Chr X: 164.37 – 164.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

C-fos-induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGF-D) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.[3]

Function[edit]

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor C.[3]

Tumor metastasis to lymph nodes[edit]

Lymph node metastasis is very often associated with several types of human malignancies. Cancer cells’ journey to lymph node takes place largely through lymphatic tunnel located in and around of primary tumor. VEGF-D’s interactions with VEGFR-3 predominantly expressed in lymphatic vessels plays a key role in restructuring lymphatic channel and, hence, able to alter its functions related to fluid and cell transport along the conduits. VEGF-D has been established to be over-expressed in both tumor tissues and patients’ serum samples in several types of human cancer. In addition, VEGF-D expression has been implicated with increased incidence of regional lymph node metastasis. In experimental mice study, genetically modified tumor cell that was forced to produce VEGF-D protein have been established to boost up regional lymph nodes metastases.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: FIGF c-fos induced growth factor (vascular endothelial growth factor D)". 
  4. ^ Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, Jackson DG, Nishikawa S, Kubo H, Achen MG (Feb 2001). "VEGF-D promotes the metastatic spread of tumor cells via the lymphatics". Nature Medicine. 7 (2): 186–91. doi:10.1038/84635. PMID 11175849. 

Further reading[edit]