Natriuretic peptide precursor C

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases NPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDs MGI: 97369 HomoloGene: 7867 GeneCards: NPPC
RNA expression pattern
PBB GE NPPC 221348 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 231.92 – 231.93 Mb Chr 1: 86.67 – 86.67 Mb
PubMed search [1] [2]
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Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[3][4][5] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).


Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[3] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[6]

Structure of C-type natriuretic peptide (human)


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: NPPC natriuretic peptide precursor C". 
  4. ^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. PMID 8330189. doi:10.1016/0006-8993(93)91649-D. 
  5. ^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. PMID 7698765. doi:10.1006/geno.1994.1633. 
  6. ^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. PMID 8959763. doi:10.1016/S0196-9781(96)00110-6. 

Further reading[edit]

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