C16 or C-16 may refer to:
- HMS C16, a 1908 British C class submarine
- Sauber C16, a 1997 racing car
- IEC 60320 C16, an electrical connector used for electric kettles and other small appliances which become hot in normal use.
- C16, the ICD-10 code for Stomach cancer
- Caldwell 16 (NGC 7243), an open cluster in the constellation Lacerta
- C16 (drug), a protein kinase inhibitor used in scientific research
- Heckler & Koch GMG (Canadian designation C16 Close Area Suppression Weapon)
- The 16th century
- Commodore 16, a home computer
- Palmitic acid, the most common saturated fatty acid found in animals, plants and microorganisms.
C-16 may refer to
- C-16 highway (Spain), a highway in Catalonia
- the US Army designation of the Cessna 208 short-haul airliner
- French Defence, Encyclopaedia of Chess Openings code
- C-16: FBI, a TV series aired between 1997 and 1998
- Bill C-16, An Act to amend the Canadian Human Rights Act and the Criminal Code
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