C5a receptor

C5AR1
Identifiers
Aliases	C5AR1, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
External IDs	OMIM: 113995; MGI: 88232; HomoloGene: 20413; GeneCards: C5AR1; OMA:C5AR1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 47,290,023 bp End 47,322,066 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A2|7 8.77 cM Start 15,980,668 bp End 15,993,465 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte bone marrow granulocyte bone marrow cells pituitary gland right lung anterior pituitary periodontal fiber upper lobe of left lung Top expressed in granulocyte aortic valve stroma of bone marrow ascending aorta blood tibiofemoral joint lumbar spinal ganglion ankle choroid plexus of fourth ventricle right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function complement component C5a binding signal transducer activity complement receptor activity complement component C5a receptor activity G protein-coupled receptor activity Cellular component integral component of membrane membrane plasma membrane apical part of cell integral component of plasma membrane cell surface basolateral plasma membrane cytoplasmic vesicle secretory granule membrane Biological process negative regulation of neuron apoptotic process positive regulation of epithelial cell proliferation mRNA transcription by RNA polymerase II activation of phospholipase C activity neutrophil chemotaxis positive regulation of angiogenesis chemotaxis cellular defense response response to lipopolysaccharide animal organ regeneration immune response response to peptidoglycan positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis complement receptor mediated signaling pathway sensory perception of chemical stimulus positive regulation of vascular endothelial growth factor production cell proliferation in hindbrain positive regulation of macrophage chemotaxis signal transduction defense response to Gram-positive bacterium apoptotic process regulation of complement activation inflammatory response phospholipase C-activating G protein-coupled receptor signaling pathway neutrophil degranulation leukocyte migration cell chemotaxis positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway complement component C5a signaling pathway cognition regulation of astrocyte activation presynapse organization regulation of amyloid-beta clearance regulation of tau-protein kinase activity regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 728 12273 Ensembl ENSG00000197405 ENSMUSG00000049130 UniProt P21730 P30993 RefSeq (mRNA) NM_001736 NM_001173550 NM_007577 RefSeq (protein) NP_001727 NP_001167021 NP_031603 Location (UCSC) Chr 19: 47.29 – 47.32 Mb Chr 7: 15.98 – 15.99 Mb PubMed search
Wikidata
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The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.

C5a receptor structure and its residues possessing role in ligand binding or signaling.

Cells

The C5a receptor is expressed on:

• Granulocytes
• Monocytes
• Dendritic cells
• Hepatoma-derived cell line HepG2
• Astrocytes
• Microglia

See also

• Complement component 5a for binding mechanism

Further reading

• Sengeløv H (1996). "Complement receptors in neutrophils". Critical Reviews in Immunology. 15 (2): 107–31. doi:10.1615/critrevimmunol.v15.i2.10. PMID 8573284.
• Beil WJ, Schulz M, Wefelmeyer U (Jul 2000). "Mast cell granule composition and tissue location--a close correlation". Histology and Histopathology. 15 (3): 937–46. PMID 10963136.
• Yamamoto T (Jan 2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes". Pathology International. 57 (1): 1–11. doi:10.1111/j.1440-1827.2007.02049.x. PMID 17199736.
• Bao L, Gerard NP, Eddy RL, Shows TB, Gerard C (Jun 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600.
• Gerard NP, Gerard C (Feb 1991). "The chemotactic receptor for human C5a anaphylatoxin". Nature. 349 (6310): 614–7. doi:10.1038/349614a0. PMID 1847994.
• Boulay F, Mery L, Tardif M, Brouchon L, Vignais P (Mar 1991). "Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells". Biochemistry. 30 (12): 2993–9. doi:10.1021/bi00226a002. PMID 2007135.
• Wahl SM, Allen JB, Gartner S, Orenstein JM, Popovic M, Chenoweth DE, Arthur LO, Farrar WL, Wahl LM (May 1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". Journal of Immunology. 142 (10): 3553–9. PMID 2541200.
• Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA (Sep 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation. 94 (3): 1147–55. doi:10.1172/JCI117430. PMC 295185. PMID 7521884.
• Giannini E, Brouchon L, Boulay F (Aug 1995). "Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo". The Journal of Biological Chemistry. 270 (32): 19166–72. doi:10.1074/jbc.270.32.19166. PMID 7642584.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Buhl AM, Osawa S, Johnson GL (Aug 1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". The Journal of Biological Chemistry. 270 (34): 19828–32. doi:10.1074/jbc.270.34.19828. PMID 7649993.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Wennogle LP, Conder L, Winter C, Braunwalder A, Vlattas S, Kramer R, Cioffi C, Hu SI (Jul 1994). "Stabilization of C5a receptor--G-protein interactions through ligand binding". Journal of Cellular Biochemistry. 55 (3): 380–8. doi:10.1002/jcb.240550316. PMID 7962171.
• Gerard NP, Bao L, Xiao-Ping H, Eddy RL, Shows TB, Gerard C (Feb 1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene". Biochemistry. 32 (5): 1243–50. doi:10.1021/bi00056a007. PMID 8383526.
• Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C (Aug 1996). "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry. 271 (34): 20231–4. doi:10.1074/jbc.271.34.20231. PMID 8702752.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Werfel T, Zwirner J, Oppermann M, Sieber A, Begemann G, Drommer W, Kapp A, Götze O (Aug 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin". Journal of Immunology. 157 (4): 1729–35. PMID 8759762.
• Höpken UE, Lu B, Gerard NP, Gerard C (Sep 1996). "The C5a chemoattractant receptor mediates mucosal defence to infection". Nature. 383 (6595): 86–9. doi:10.1038/383086a0. PMID 8779720.
• Chen Z, Zhang X, Gonnella NC, Pellas TC, Boyar WC, Ni F (Apr 1998). "Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin". The Journal of Biological Chemistry. 273 (17): 10411–9. doi:10.1074/jbc.273.17.10411. PMID 9553099.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Floreani AA, Heires AJ, Welniak LA, Miller-Lindholm A, Clark-Pierce L, Rennard SI, Morgan EL, Sanderson SD (May 1998). "Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke". Journal of Immunology. 160 (10): 5073–81. PMID 9590258.
• Ottonello L, Corcione A, Tortolina G, Airoldi I, Albesiano E, Favre A, D'Agostino R, Malavasi F, Pistoia V, Dallegri F (Jun 1999). "rC5a directs the in vitro migration of human memory and naive tonsillar B lymphocytes: implications for B cell trafficking in secondary lymphoid tissues". Journal of Immunology. 162 (11): 6510–7. PMID 10352266.
• Kohleisen B, Shumay E, Sutter G, Foerster R, Brack-Werner R, Nuesse M, Erfle V (Dec 1999). "Stable expression of HIV-1 Nef induces changes in growth properties and activation state of human astrocytes". Aids. 13 (17): 2331–41. doi:10.1097/00002030-199912030-00004. PMID 10597774.
• Monk PN, Scola AM, Madala P, Fairlie DP (Oct 2007). "Function, structure and therapeutic potential of complement C5a receptors". British Journal of Pharmacology. 152 (4): 429–48. doi:10.1038/sj.bjp.0707332. PMC 2050825. PMID 17603557.

External links

• "Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• C5a+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)