CA11

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CA11
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CA11, CARPX1, carbonic anhydrase 11
External IDs MGI: 1336193 HomoloGene: 36061 GeneCards: CA11
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CA11
Genomic location for CA11
Band 19q13.33 Start 48,637,942 bp[1]
End 48,646,312 bp[1]
RNA expression pattern
PBB GE CA11 209726 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001217

NM_009800

RefSeq (protein)

NP_001208

NP_033930

Location (UCSC) Chr 19: 48.64 – 48.65 Mb Chr 19: 45.7 – 45.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene.[5][6]

Function[edit]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.[6]

Interactions[edit]

CA11 has been shown to interact with RIPK1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063180 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003273 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW, Tashian RE (Feb 1999). "Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3". Genomics. 54 (3): 484–93. PMID 9878252. doi:10.1006/geno.1998.5585.  Check date values in: |year= / |date= mismatch (help)
  6. ^ a b "Entrez Gene: CA11 carbonic anhydrase XI". 
  7. ^ Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El-Deiry WS, Schütze S, Srinivasula SM (May 2008). "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation". Curr. Biol. 18 (9): 641–9. PMC 2587165Freely accessible. PMID 18450452. doi:10.1016/j.cub.2008.04.017. 

External links[edit]

Further reading[edit]