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EC number
CAS number 122319-88-4
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2-carboxy-D-arabinitol-1-phosphatase (also called CA1Pase; EC is an enzyme that catalyzes the chemical reaction

2-carboxy-D-arabinitol 1-phosphate + H2O 2-carboxy-D-arabinitol + phosphate

Thus, the two substrates of this enzyme are 2-carboxy-D-arabinitol 1-phosphate and H2O, whereas its two products are 2-carboxy-D-arabinitol and phosphate.

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase.

In biology[edit]

The best-studied 2-Carboxy-D-arabinitol-1-phosphate phosphatase is the enzyme that inactivates the RuBisCO inhibitor 2-carboxy-D-arabinitol-1-phosphate (CA1P).

When light levels are high, the inactivation occurs after CA1P has been released from RuBisCO by RuBisCO activase. As CA1P is present in many but not all plants, CA1P-mediated regulation of RuBisCO is not universal for all photosynthetic life. Amino acid sequences of the CA1Pase enzymes from wheat, French bean, tobacco, and Arabidopsis reveal that the enzymes contain 2 different domains, indicating that it is a multifunctional enzyme.

CA1Pase enzyme activity varies between different species due to their regulation by different redox-active compounds, such as glutathione. However, it is yet to be determined whether this process occurs in vivo. Wheat CA1Pase heterologously expressed in E. coli is also able to dephosphorylate the RuBisCO inhibitor D-glycero-2,3-diulose-1,5-bisphosphate.[1]


  1. ^ Andralojc, J., P. Madgwick, et al. (2006). "Properties of CA1P phosphatase and its role in rubisco regulation." Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology 143(4): S173-S173.
  • Salvucci ME; Holbrook GP (1989). "Purification and properties of 2-carboxy-D-arabinitol 1-phosphatase". Plant Physiol. 90: 679–685. doi:10.1104/pp.90.2.679.