CADPS2

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CADPS2
Identifiers
Aliases CADPS2, CAPS2, calcium dependent secretion activator 2
External IDs MGI: 2443963 HomoloGene: 23060 GeneCards: CADPS2
RNA expression pattern
PBB GE CADPS2 219572 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001009571
NM_001167940
NM_017954

RefSeq (protein)

NP_001009571
NP_001161412
NP_060424

Location (UCSC) Chr 7: 122.32 – 122.89 Mb Chr 6: 23.26 – 23.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Calcium-dependent secretion activator 2 is a protein that in humans is encoded by the CADPS2 gene.[3]

Function[edit]

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells.[3]

Interactions[edit]

This gene interacts with brain-derived neurotrophic factor.

Clinical significance[edit]

Cadps2 has been linked to autism[4] and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.[5]

A knockout mouse model was found to have autistic-like characteristics.[4]

CADPS2 has been linked to human and mouse brain structure in two large genomic studies.[6][7]

References[edit]

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.